A5101609442- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Endometriosis Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- MRI in cancer diagnosis
- Venous Thromboembolism Diagnosis and Management
- Ultrasound in Clinical Applications
- Uterine Myomas and Treatments
- Renal Diseases and Glomerulopathies
- Molecular Biology Techniques and Applications
- Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Genital Health and Disease
- Immune Response and Inflammation
- Sarcoma Diagnosis and Treatment
- Cardiovascular Effects of Exercise
- Gynecological conditions and treatments
- Estrogen and related hormone effects
- PI3K/AKT/mTOR signaling in cancer
- Testicular diseases and treatments
- Chemotherapy-induced organ toxicity mitigation
International University of Health and Welfare
2023
Tokyo Metropolitan Komagome Hospital
2018
University of Tsukuba
2007-2016
National Cancer Center
1991-2016
Metropolitan Hospital
2015
Metropolitan Hospital Center
2015
Tokyo Metropolitan Bokutoh Hospital
2015
Hyogo Prefectural Cancer Center
2014
Kurume University
2014
Kitasato University
2014
To obtain baseline data for human papillomavirus (HPV) screening and vaccination in Japan, we analyzed HPV DNA from 2282 Japanese women (1517 normal cytology, 318 cervical intraepithelial neoplasia [CIN] grade 1, 307 CIN2–3, 140 invasive cancer [ICC]) that visited the University of Tsukuba Hospital or Ibaraki Seinan Medical Center treatment diseases between 1999 2007. An L1‐based PCR method was used individual genotyping. The most common types ICC were, order decreasing prevalence, HPV16...
Venous thromboembolism (VTE) such as deep-vein thrombosis (DVT) and pulmonary (PTE) often occurs after surgery rarely even before in patients with ovarian cancer. It is well known that levels of plasma D-dimer (DD) treatment most cancer are increased. This study therefore examined whether increased DD associated presence VTE Between November 2004 March 2007, prior to initial were measured 72 consecutive presumed epithelial (final diagnosis: cancer, n=60; borderline malignancy, n=12)....
OBJECTIVE. Although mural nodules are considered to be the most important hallmark in recognition of ovarian cancers accompanied with endometriotic cysts, benign neoplasms and even inflammatory diseases can show similar MRI findings. We sought clarify characteristics malignancy cysts ovary.
Venous thromboembolism (VTE) often occurs after surgery and can even occur before in patients with gynaecological malignancies. We investigated the incidence of VTE treatment endometrial cancer associated risk factors. Plasma D-dimer (DD) levels initial were examined 171 consecutive cancer. ultrasound imaging (VUI) lower extremities was performed DD ⩾1.5 μg ml−1, as negative predictive value for is extremely high. For deep vein thrombosis (DVT), pulmonary scintigraphy to ascertain presence...
Primary epithelial ovarian carcinoma is sub-classified into serous, mucinous, endometrioid and clear cell subtypes. Neoadjuvant chemotherapy has become an alternative treatment option past several years, as serous carcinoma, the most common subtype, known chemotherapy-sensitive tumor. On other hand, mucinous are chemotherapy-resistive. Therefore, it may be meaningful to estimate subtype of using imaging modality. The purpose this study whether CT or MRI can determine subtypes cancers.The...
To clarify the imaging characteristics of ovarian serous surface papillary borderline tumor (SSPBT), whose prognosis is far better than that adenocarcinoma (SSPC).We retrospectively reviewed clinical and findings six cases (age range, 26-58 years; mean, 43 years) with SSPBT encountered at our institute from 1996 to 2008.Serum levels CA125 were elevated, they clinically suspected have cancer. All masses almost entirely solid showed hyperintense architecture hypointense internal branching on...
Abstract To determine the specificity and significance of widespread attenuation glomerular basement membrane on electron microscopy, 240 renal biopsies from 218 children were studied retrospectively. Twenty‐three patients showed diffuse three them are cases hereditary nephritis. The other 20 characterized by persistent microscopic haematuria, absence proteinuria, normal blood pressure function, minimal changes. In 10 these children, haematuria was also present in family. We conclude that is...
Polymorphisms in cytokine genes can influence immune responses to human papillomavirus infection, possibly modifying risks of cervical cancer. Using an amplification refractory mutation system-polymerase chain reaction method, we analyzed a single nucleotide polymorphism (A/G) at position -1082 interleukin-10 promoter region 440 Japanese women: 173 women with normal cytology, 163 intraepithelial neoplasia and 104 invasive The carrier frequency G alleles associated higher production increased...
To examine the interobserver agreement level of histological diagnosis adenoma malignum (ADM), 52 proliferative endocervical glandular lesions were evaluated independently by four observers (A to D), each whom is in charge gynecological pathology at a different hospital. The correlation observer with patient outcome was also examined for 19 these lesions. When diagnoses categorized into benign including hyperplasias, ADM, and common types adenocarcinoma, consistent among all achieved only 12...
Determination of the histological type epithelial ovarian cancer is clinically important to predict patient prognosis. To estimate accurately chromosomal regions that frequently show loss heterozygosity (LOH) in each type, LOH at 55 loci on 38 arms was examined by means laser capture microdissection and PCR-LOH analysis 45 cancers composed clear cell adenocarcinoma (CCA), serous (SEA), endometrioid (EMA) mucinous (MUA). In addition, p53 (exons 5 - 8) gene mutations nuclear immunoreactivity...
To differentiate primary mucinous ovarian neoplasms from metastatic ones with MR using diversity in size and signal intensity of multilocular cystic masses.Twenty-eight cases malignant or borderline 14 tumors were retrospectively reviewed. We analyzed whether the tumor was unilateral bilateral, each loculus tumors, namely ratio smallest/largest (size ratio), standard deviation at level most varying on T2-weighted images within (signal ratio). performed statistical analysis Mann-Whitney...
Abstract Aim: Repeated treatment with carboplatin increases the incidence of hypersensitivity reactions. Current managements for reactions involve premedication, desensitization, and replacing agents. However, preventive effects recurrent by former two methods are still limited, substituting non‐platinum agent can attenuate efficacy against platinum‐sensitive diseases. The aim this study was to evaluate safety nedaplatin, another platinum compound, as a strategy deal in gynecologic cancers....
Research Articles| February 23 2011 Cytodiagnostic Problems in Uterine Sarcoma: Analysis According to a Novel Classi.cation of Tumor Growth Types Subject Area: Pathology and Cell Biology Katsutoshi Oda; Oda From the Department Gynecology Diagnostic Cytology, Saitama Cancer Center, Saitama, Obstetrics Gynecology, Faculty Medicine, University Tokyo, Japan. Search for other works by this author on: This Site PubMed Google Scholar Satoshi Okada; Okada Tomomi Nei; Nei Takako Shirai; Shirai...
Tumor volumetry with magnetic resonance imaging (MRI) is very common; however, the accuracy of such measures remains unclear, especially after treatment.To determine preoperative volume measurements uterine cervical carcinomas resected and without neoadjuvant chemotherapy (NAC) on T2-weighted (T2W) diffusion-weighted (DWI) MRI.Twenty-nine consecutive patients surgically confirmed carcinoma were included in this study. MRI scans performed before treatment 17 two courses NAC 12 patients. In...
背景 : 卵巣癌の早期発見・治療は難しく, 約半数がⅢ・Ⅳ期の進行癌で発見され, なかには急速に進行するものもある. 子宮内膜細胞診のみ陽性で, 術前画像検査で病変は指摘できなかったが, 開腹手術時には広範囲な腹腔内播種をきたしていた卵巣漿液性腺癌症例を経験したので報告する. 症例 49 歳, 女性. 不正出血を主訴に近医受診し, 子宮内膜細胞診疑陽性のため当院へ紹介となった. 細胞診再検や, 画像検査で悪性所見なく, 定期的に経過観察していた. 1 年 6 ヵ月後, 症状はないものの, 子宮内膜細胞診が再度陽性となり当院を再診した. 子宮内膜細胞診では, 腫瘍性背景を欠き孤立散在性に腺癌細胞を認め, 漿液性腺癌が疑われた. 子宮頸部・内膜組織診で悪性所見なく, 画像検査では明らかな原発病変は指摘できなかった. 小さな子宮体癌を第一に考え手術の方針とし, 再診より ヵ月後に開腹手術を施行した. 開腹時, 20 mm を超える腹腔内播種が多発した卵巣癌Ⅲc 期の状態であり, primary debulking surgery を行った. 切除標本では子宮内膜には病変を認めず,...
The platinum-free interval is defined as the period between completion of platinum-based primary chemotherapy for ovarian cancer and disease recurrence. Platinum sensitivity refers to women with who have a more than 6 months. These usually undergo second-line chemotherapy; response rates range from 27% 65% median survival 12 24 Women less months are considered be platinum resistant; in these 10% 30% 9 There few data on efficacy endometrial cancer. Also, there no definitive evidence...