A5057565200- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Colorectal Cancer Treatments and Studies
- Radiopharmaceutical Chemistry and Applications
- Gastric Cancer Management and Outcomes
- Acute Myeloid Leukemia Research
- Glycosylation and Glycoproteins Research
- Metastasis and carcinoma case studies
- Cancer Treatment and Pharmacology
- Chronic Lymphocytic Leukemia Research
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Helicobacter pylori-related gastroenterology studies
- Lung Cancer Treatments and Mutations
- Asthma and respiratory diseases
- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
- Tracheal and airway disorders
- Childhood Cancer Survivors' Quality of Life
- Tendon Structure and Treatment
- Drug Transport and Resistance Mechanisms
- Angiogenesis and VEGF in Cancer
The London College
2025
Imperial College London
2022-2025
Hiroshima International University
2022-2024
Eisai (Japan)
1996-2024
Nagoya University
2022
Hokkaido University
2022
Osaka Prefecture University
2020-2021
Kyushu University
2015-2021
Graduate School USA
2016-2021
University of Chicago
2018-2020
NF-IL6, a member of the basic leucine zipper (bZIP) family transcription factors, is involved in expression inducible genes immune and inflammatory responses. We observed that coexpression oncogenic p21ras stimulated transactivating activity NF-IL6 induced phosphorylation Thr-235 located just N-terminal to DNA binding domain NF-IL6. Recently, mitogen-activated protein (MAP) kinases have been shown be implicated cellular response activated ras. Purified MAP specifically phosphorylated vitro....
Core binding factor beta (CBF beta) is considered to be a transcriptional coactivator that dimerizes with transcription factors core alpha 1 (CBFA1), -2, and -3, enhances DNA capacity of these factors. CBF CBFA2, which also called acute myeloid leukemia gene, are frequently involved in chromosomal translocations human leukemia. To elucidate the function beta, mice carrying mutation Cbfb locus were generated. Homozygous mutant embryos died between embryonic days 11.5-13.5 due hemorrhage...
Laminin, as a key component of the basement membrane extracellular matrix (ECM), regulates tissue morphogenesis. Here, we show that multiple laminin isoforms promiscuously bind to growth factors (GFs) with high affinity, through their heparin-binding domains (HBDs) located in α chain laminin-type G (LG) domains. These also syndecan cell-surface receptors, promoting attachment fibroblasts and endothelial cells. We explore application these multifunctional HBDs wound healing type-2 diabetic...
An engineered cancer immunotherapy using a collagen-binding domain enhances efficacy and reduces adverse events.
Six transmembrane epithelial antigen of the prostate 1 (STEAP1) is a cell surface for therapeutic targeting in cancer. Here, we report broad expression STEAP1 relative to prostate-specific membrane (PSMA) lethal metastatic cancers and development STEAP1-directed chimeric receptor (CAR) T therapy. CAR cells demonstrate reactivity low density, antitumor activity across cancer models, safety human knock-in mouse model. escape recurrent mechanism treatment resistance associated with diminished...
CCAAT/enhancer binding protein α (C/EBPα) is an integral factor in the granulocytic developmental pathway, as myeloblasts from C/EBPα-null mice exhibit early block differentiation. Since deficient for known C/EBPα target genes do not same granulocyte maturation, we sought to identify additional essential myeloid cell development. To such genes, used both representational difference analysis and oligonucleotide array with RNA derived a C/EBPα-inducible line. From each of these independent...
Serum albumin (SA) is used as a carrier to deliver cytotoxic agents tumors via passive targeting. To further improve SA's tumor targeting capacity, we sought develop an approach retain SA-drug conjugates within through combination of and active SA was recombinantly fused with collagen-binding domain (CBD) von Willebrand factor bind the stroma after extravasation due vascular permeability. Doxorubicin (Dox) conjugated CBD-SA pH-sensitive linker. Dox-CBD-SA treatment significantly suppressed...
Preventing distant recurrence and achieving local control are important challenges in rectal cancer treatment, use of adjuvant chemotherapy has been studied. However, no phase III study comparing regimens for demonstrated superiority a specific regimen. We therefore conducted to evaluate the S-1 tegafur-uracil (UFT), standard regimen curatively resected stage II/III Japan, setting cancer.The ACTS-RC trial was an open-label, randomized, at 222 sites Japan. Patients aged 20-80 with undergoing...
Abstract Metastatic castration-resistant prostate cancer (mCRPC) is a major cause of cancer-related deaths among men in the United States, with limited effectiveness from current immunotherapies due to cancer’s immunologically ‘cold’ nature. Chimeric antigen receptor (CAR) T cell therapies have transformed treatment paradigms hematologic cancers, but achieving similar success solid tumors like remains challenging. Most CAR for target prostate-specific membrane (PSMA) or stem (PSCA); however,...
Immunosuppressive microenvironments, the lack of immune infiltration, and antigen heterogeneity pose significant challenges for chimeric receptor (CAR)-T cell therapies to tackle solid tumors. CAR-T cells were armed with immunostimulatory payloads, such as interleukin-12 (IL-12), overcome this issue, but faced intolerable toxicity during clinical development. Here, we show that collagen-binding domain-fused IL-12 (CBD-IL-12) was retained within syngeneic murine prostate tumors, after...
Abstract Metastatic castration-resistant prostate cancer (mCRPC) is a largely incurable, immunologically cold solid tumor. Six-transmembrane epithelial antigen of the 1 (STEAP1) promising target specifically expressed in >85% mCRPC patients. Chimeric receptor (CAR)-T cells transformed clinical landscape blood cancers. However, CAR-T therapy still not very effective against cancers including cancer, part due to immunosuppressive tumor microenvironment (TME) and heterogeneity....
To investigate overall chromosomal alterations using array-based comparative genomic hybridisation (CGH) of myxoid liposarcomas (MLSs) and myxofibrosarcomas (MFSs).Genomic DNA extracted from fresh-frozen tumour tissues was labelled with fluorochromes then hybridised on to an array consisting 1440 bacterial artificial chromosome clones representing regions throughout the entire human genome important in cytogenetics oncology.DNA copy number aberrations (CNAs) were found all 8 MFSs, but no 7...
Fc-binding antibody-recruiting molecules provide robust and sufficient opportunities to employ endogenous antibodies for anti-tumor immune responses.
pH-Sensitive branched β-glucan-modified liposomes promote antigen uptake and activation of dendritic cells in vitro , inducing anti-tumor immune responses vivo .
In order to estimate the prognostic values of p27(Kip1), p21(Waf1/Cip1), and p53, alone in combination, we investigated immunohistochemically expression p53 proteins gastric carcinomas.The was examined 140 carcinomas. Positive p27(Kip1) p21(Waf1/Cip1) correlated significantly with a favourable prognosis (P < 0.05), whereas, positive tended correlate poor prognosis. Multivariate survival analysis revealed that TNM stage tumour 0.001), lymph node state (P=0.005), (P=0.006) were independent...
Abstract In Japan and Korea, outbreaks of scuticociliatosis have frequently occurred in Japanese flounder, Paralichthys olivaceus . Morphological observations small subunit rRNA gene sequences shown that the causative agent flounder is Miamiensis avidus (syn. Philasterides dicentrarchi ). this study, we elucidated antigenic differences between six M. isolates as an initial step toward developing effective vaccine against disease. Four (IyoI, Nakajima, JF05To Mie0301 isolates), one spotted...