A5023657477- Prostate Cancer Treatment and Research
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
- Hormonal and reproductive studies
- Radiopharmaceutical Chemistry and Applications
- Estrogen and related hormone effects
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Chemical Synthesis and Analysis
- Structural Load-Bearing Analysis
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Mechanical stress and fatigue analysis
- Immunotherapy and Immune Responses
- Computational Drug Discovery Methods
- Enzyme Catalysis and Immobilization
- Advanced Nanomaterials in Catalysis
- Structural Behavior of Reinforced Concrete
- Advanced battery technologies research
- Advancements in Battery Materials
- Microplastics and Plastic Pollution
- Sarcoma Diagnosis and Treatment
- Medicinal Plant Pharmacodynamics Research
Beijing University of Civil Engineering and Architecture
2025
Sichuan University
2025
Guangxi University
2023-2024
Harbin Institute of Technology
2022-2024
Tianjin Medical University
2023-2024
Ministry of Agriculture and Rural Affairs
2024
China Agricultural University
2024
Fred Hutch Cancer Center
2016-2023
Wesley Hospital
2023
Canberra Hospital
2021
Six transmembrane epithelial antigen of the prostate 1 (STEAP1) is a cell surface for therapeutic targeting in cancer. Here, we report broad expression STEAP1 relative to prostate-specific membrane (PSMA) lethal metastatic cancers and development STEAP1-directed chimeric receptor (CAR) T therapy. CAR cells demonstrate reactivity low density, antitumor activity across cancer models, safety human knock-in mouse model. escape recurrent mechanism treatment resistance associated with diminished...
Prostate-specific membrane antigen (PSMA) is an important cell surface target in prostate cancer. There are limited data on the heterogeneity of PSMA tissue expression metastatic castration-resistant cancer (mCRPC). Furthermore, mechanisms regulating (encoded by FOLH1 gene) not well understood. Here, we demonstrate that heterogeneous across different sites and molecular subtypes mCRPC. In a rapid autopsy cohort which multiple per patient were sampled, found 13 52 (25%) cases had no...
Abstract Purpose: Neuroendocrine prostate cancer (NEPC) is an aggressive form of castration-resistant (CRPC) for which effective therapies are lacking. We previously identified carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) as a promising NEPC surface antigen. Here we investigated the scope CEACAM5 expression in end-stage cancer, basis enrichment NEPC, and therapeutic potential antibody–drug conjugate labetuzumab govitecan cancer. Experimental Design: The other...
Abstract Purpose: Tumor androgens in castration-resistant prostate cancer (CRPC) reflect de novo intratumoral synthesis or adrenal androgens. We used C.B.-17 SCID mice which we observed CYP17A activity to isolate the impact of steroids on CRPC tumors vivo. Experimental Design: evaluated tumor growth and LuCaP35CR LuCaP96CR xenografts response adrenalectomy (ADX). assessed protein expression key steroidogenic enzymes 185 metastases from 42 patients. Results: Adrenal glands intact castrated...
ABSTRACT This paper proposes a built‐in octagonal encase steel core tube fully bolted assembly CFSST column connection joint (OCFSST). The proposed static test study was carried out on this and the welded (WCFSST), data were processed, analyzed, compared in terms of hysteresis curves, skeleton stiffness degradation, displacement ductility, bolt preload, strain changes, area angle. average value horizontal bearing capacity is 5.60% higher than that joint, which proves has better mechanical...
Tirzepatide, a dual glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist, demonstrates promise as potent medication for obesity. However, the extent to which its weight-reducing effects go beyond suppressing appetite remains unclear. This study aimed elucidate this by establishing pair-fed control group, effectively eliminating influence of reduced caloric intake. Mice fed on chow diet or high-fat received single long-term...
Abstract Purpose: Germline variation in solute carrier organic anion (SLCO) genes influences cellular steroid uptake and is associated with prostate cancer outcomes. We hypothesized that, due to its steroidal structure, the CYP17A inhibitor abiraterone may undergo transport by SLCO-encoded transporters that SLCO gene influence intracellular levels Experimental Design: Steroid were measured serum tissue from 58 men localized a clinical trial of LHRH agonist plus acetate prednisone for 24...
To reconstruct massive bone defects of the femoral diaphysis and proximal end with limited bilateral cortical after joint-preserving musculoskeletal tumor resections, two novel 3D-printed customized intercalary prostheses were applied.A series nine patients malignancies who received these retrospectively studied between July 2018 November 2021. The diaphyseal femur was divided into three regions interest (ROIs) according to anatomic landmarks, measurements conducted on 50 computed tomography...
Abstract Background Testosterone is a driver of prostate cancer (PC) growth via ligand‐mediated activation the androgen receptor (AR). Tumors that have escaped systemic deprivation, castration‐resistant cancers (CRPC), measurable intratumoral levels testosterone, suggesting resistance mechanism still depends on androgen‐simulated growth. However, AR requires an optimal intracellular concentration androgens, situation challenged by low circulating testosterone concentrations. Notably, PC...
Castration-resistant prostate cancer (CRPC) consists of multiple phenotypic subtypes including androgen receptor (AR)-active (ARPC) and neuroendocrine (NEPC). Tumor cells with these phenotypes can coexist between metastases within a patient an individual tumor. Treatments that are effective across CRPC currently lacking. Histone deacetylation is crucial for the regulation chromatin structure maintenance cell state activation PI3K/AKT/mTOR signaling cascade tumor growth-promoting pathway. We...
The bacteriostatic mechanism of resveratrol (RES) on Acetobacter sp. based the cell membrane, intracellular enzymes and DNA was studied. Our results showed that minimum inhibition concentration (MIC) RES 2 mg/mL, growth curve confirmed its better activity against content unsaturated fatty acids (UFAs) hydroxyl (HFAs) membrane after low-concentration treatment increased, while saturated (SFAs) cyclic (CFAs) decreased. Furthermore, acid-related genes (fabA, fabG, cfa) stress-regulating gene...