A5042005692- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Chromosomal and Genetic Variations
- Genomic variations and chromosomal abnormalities
- Protein Degradation and Inhibitors
- Cancer Genomics and Diagnostics
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
Fred Hutch Cancer Center
2023-2024
Jawaharlal Nehru Centre for Advanced Scientific Research
2018-2022
Gene Therapy Laboratory
2017
Prostate-specific membrane antigen (PSMA) is an important cell surface target in prostate cancer. There are limited data on the heterogeneity of PSMA tissue expression metastatic castration-resistant cancer (mCRPC). Furthermore, mechanisms regulating (encoded by FOLH1 gene) not well understood. Here, we demonstrate that heterogeneous across different sites and molecular subtypes mCRPC. In a rapid autopsy cohort which multiple per patient were sampled, found 13 52 (25%) cases had no...
Multifunctional human transcriptional positive co‐activator 4 (PC4) is a bona fide nonhistone component of the chromatin and plays pivotal role in process compaction functional genome organization. Knockdown PC4 expression causes drastic decompaction which leads to open conformation chromatin, thereby altered nuclear architecture, defects chromosome segregation changed epigenetic landscape. Interestingly, these do not induce cellular death but result enhanced proliferation, possibly through...
Abstract Human Positive Coactivator 4 (PC4) is a multifaceted chromatin protein involved in diverse cellular processes including genome organization, transcription regulation, replication, DNA repair and autophagy. PC4 exists as phospho-protein cells which impinges on its acetylation by p300 thereby affects transcriptional co-activator functions via double-stranded binding. Despite the inhibitory effects, abundance of phosphorylated intrigued us to investigate role basal state cell. We found...
Abstract Introduction: Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease which can be classified into clinically relevant subtypes based on the expression of genes, such as androgen receptor (AR) and neuroendocrine markers. Neuroendocrine (NEPC), characterized by gain stem-like features lack AR aggressive variant. Due to adequate biomarkers, NEPC usually detected at very advanced stage. There mounting evidence that molecular subtype changes seen in are...
Abstract Introduction: Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease which can be classified into clinically relevant subtypes based on the expression of transcription factors (TF), such as androgen receptor (AR) and neuroendocrine markers. Neuroendocrine (NEPC), characterized by gain stem-like features lack AR aggressive variant. Due to absence adequate biomarkers, NEPC usually detected at very advanced stage. There mounting evidence that molecular...
Abstract Background: DNA methylation alterations are a universal feature of cancer. In addition to site specific gain (hypermethylation), global loss (hypomethylation) was noted in most cancer genomes. Whereas numerous studies have focused on the role hypermethylation disease progression, less is known about biology hypomethylation Recently, we identified tumors across all major types that characterized by severe methylation. Our preliminary data suggest these hypomethylated cancers...
Abstract Multifunctional human transcriptional positive co-activator 4 (PC4) is a bonafide non-histone component of the chromatin and plays pivotal role in process compaction functional genome organization. Knockdown PC4 expression leads to drastic open conformation thereby altered nuclear architecture, defects chromosome segregation changed epigenetic landscape. Interestingly, these do not induce cellular death but result enhanced proliferation possibly through autophagic activity....