A5078994802- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Galectins and Cancer Biology
- Hedgehog Signaling Pathway Studies
- Advanced Battery Materials and Technologies
- Autophagy in Disease and Therapy
- Kruppel-like factors research
- Advanced battery technologies research
- Glycosylation and Glycoproteins Research
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Radiation Therapy and Dosimetry
- Advanced Fiber Laser Technologies
- Effects of Radiation Exposure
- Brain Metastases and Treatment
- PARP inhibition in cancer therapy
- Optical Network Technologies
- Ubiquitin and proteasome pathways
- Telomeres, Telomerase, and Senescence
- Enterobacteriaceae and Cronobacter Research
- Neurogenesis and neuroplasticity mechanisms
- Cell death mechanisms and regulation
- Retinoids in leukemia and cellular processes
Weizmann Institute of Science
2021-2024
Jadavpur University
2023
Bar-Ilan University
2021
KIIT University
2014-2019
Tata Medical Center
2017
Purpose: Radiation therapy is an integral part of current treatment modality for colorectal cancer. Recent studies have revealed the presence cancer stem-like cells (CSCs) population, in different tumors are responsible therapeutic resistance and disease relapse, including with poorer survival rate. Hence, characterization effect Ionizing (IR) may serve to explain possible mechanisms. Material methods: Parental HCT116 HCT-15 derived colonospheres were irradiated dose was optimized based on...
This study aimed to investigate the role of p38 MAPK in maintenance cancer stem cell (CSC) phenotype, therapy resistance, and DNA damage repair response head neck squamous carcinoma (HNSCC).In this study, 104 HNSCC patients were included. Western blot, immunohistochemistry, qPCR analysis performed expression level p-p38 CSC markers cut margin tumor area patients. The was also evaluated cells with or without inhibitor. Chemoresistance, wound healing capacity, multicellular spheroids (MCTS)...
Extensive efforts are currently underway to develop safe and cost-effective electrolytes for large-scale energy storage. In this regard, water-based may be an attractive option, but their narrow electrochemical stability window hinders realization. Although highly concentrated fluorinated have been shown effective in suppression of water splitting, enabling significant widening the applied potential range, they utilize expensive salts (e.g., lithium bis(trifluoromethane sulfonyl) imide...
Tumorigenesis is a complex process of accumulated alteration in function multiple genes and pathways. Wnt signalling pathway involved various differentiation events during embryonic development conserved species.A multicentre collaborative initiative undertaken to study the occurrence, prognosis molecular mechanism HNSCC (Head Neck Squamous Cell Carcinoma) which highly prevalent eastern parts India. From large cohort tissue repository, 67 cases were selected for multi-parametric...
TRF2 is a telomere binding protein, component of the shelterin complex that plays major role in maintaining integrity genome. over-expressed number human cancers including Head and Neck cancer might play key tumor initiation development. p38 MAPK signaling pathway strongly activated response to various environmental cellular stresses thus overexpressed most cases. In this study, we investigated potential interactions with HNSCC cells patient samples. Using silico experiments, identified...
Multifunctional human transcriptional positive co‐activator 4 (PC4) is a bona fide nonhistone component of the chromatin and plays pivotal role in process compaction functional genome organization. Knockdown PC4 expression causes drastic decompaction which leads to open conformation chromatin, thereby altered nuclear architecture, defects chromosome segregation changed epigenetic landscape. Interestingly, these do not induce cellular death but result enhanced proliferation, possibly through...
Location estimation is essential to the success of location based services. Since GPS does not work well in indoor and urban areas, several localization systems have been proposed literature. Among these, fingerprinting-based involving two phases: training phase positioning phase, are used mostly. In a radio map constructed by collecting received signal strength (RSS) measurements at set known locations. whose corresponding RSS pattern matches best with currently observed selected as...
Chemotherapeutic resistance post-surgical management may be linked to an efficient DNA repair mechanism and survival of cancer stem cells.We report the presence cell like Side Population their enrichment post treatment with bleomycin in HCT116 line.The exhibited spheroidal characteristics damage foci compared parental HCT-116 upregulated expression β-catenin, TRF2, hTERT, CD44, CD24 Oct4 genes clonospheres a environment.Comparative gene studies clonospheric cells revealed significant...
Aberrant activation of Wnt/β-catenin signaling and downstream β-catenin-TCF target genes is a hallmark colorectal cancer (CRC) development. We identified the immunoglobulin-like cell adhesion receptor L1CAM (L1) as transactivation in CRC cells. Overexpression L1 cells confers enhanced proliferation, motility, tumorigenesis, liver metastasis, exclusively localized at invasive areas human tissue. Several are induced after transfection into by mechanism involving L1-ezrin-NF-κB pathway....
The cell adhesion molecule L1CAM (L1), mainly known for its function in brain cells, is a Wnt/β-catenin signaling target gene colorectal cancer (CRC) where it promotes invasion and liver metastasis. We interrogated which genes are expressed at increased levels human CRC tissue induced lines overexpressing L1. found cyclin D2 LS 174T HCT 116 cells Increased was associated with higher proliferation rates, faster motility, tumorigenesis, suppression of expression by shRNA to blocked the...
An induction in the expression of cell adhesion receptor L1, a Wnt target gene, is characteristic feature Wnt/β-catenin activation colon cancer cells at later stages disease. We investigated proteins secreted following L1 and identified Mucin2 among most abundant proteins. found that suppressing L1-expressing inhibits proliferation, motility, tumorigenesis, liver metastasis. detected several signaling pathways involved cells. In human tissue, was significantly reduced or lost adenocarcinoma...
The immunoglobulin family cell adhesion receptor L1 is induced in CRC cells at the invasive front of tumor tissue, and confers enhanced proliferation, motility, tumorigenesis, liver metastasis. To identify putative suppressors whose expression downregulated L1-expressing cells, we blocked L1–ezrin–NF-κB signaling pathway searched for genes under these conditions. We found that TFF1, a protein involved protecting mucus epithelial layer colon, displays characteristics suppressor....
Four different Photonic Crystal Fibers (PCFs) with variation in ratio of diameter air holes and hole to spacing (d/∧) has been investigated. Two equals 0.5 0.6 made quadrants hexagonal PCF structures. Structure C uniform distribution (d/∧)= shows excellent results. Besides all the structures reports very low dispersion loss.
Abstract Multifunctional human transcriptional positive co-activator 4 (PC4) is a bonafide non-histone component of the chromatin and plays pivotal role in process compaction functional genome organization. Knockdown PC4 expression leads to drastic open conformation thereby altered nuclear architecture, defects chromosome segregation changed epigenetic landscape. Interestingly, these do not induce cellular death but result enhanced proliferation possibly through autophagic activity....