A5059159251- Cancer Genomics and Diagnostics
- PARP inhibition in cancer therapy
- Pancreatic and Hepatic Oncology Research
- Wnt/β-catenin signaling in development and cancer
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Signaling Pathways in Disease
- Bariatric Surgery and Outcomes
- Gut microbiota and health
- Axon Guidance and Neuronal Signaling
- Caveolin-1 and cellular processes
- Body Contouring and Surgery
- Cellular Mechanics and Interactions
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- RNA Research and Splicing
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Cancer Research and Treatments
- Helicobacter pylori-related gastroenterology studies
- Digestive system and related health
- Neurofibromatosis and Schwannoma Cases
- Neuroblastoma Research and Treatments
- RNA modifications and cancer
- Microtubule and mitosis dynamics
Weizmann Institute of Science
2015-2024
EES Research (United Kingdom)
2019
Science Club
2019
University of Freiburg
2010
Weatherford College
2008
Tel Aviv Sourasky Medical Center
2002-2007
Tel Aviv University
2002-2007
Icahn School of Medicine at Mount Sinai
2005
Bacteria were first detected in human tumors more than 100 years ago, but the characterization of tumor microbiome has remained challenging because its low biomass. We undertook a comprehensive analysis microbiome, studying 1526 and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, brain tumors. found that each type distinct composition breast particularly rich diverse microbiome. The intratumor bacteria are mostly intracellular...
In model systems, bacteria present in human pancreatic tumors confer resistance to the anticancer drug gemcitabine.
Aberrant β-catenin-TCF target gene activation plays a key role in colorectal cancer, both the initiation stage and during invasion metastasis. We identified neuronal cell adhesion molecule L1, as of signaling cancer cells. L1 expression was high sparse cultures coregulated with ADAM10, metalloprotease involved cleaving shedding L1's extracellular domain. conferred increased motility, growth low serum, transformation tumorigenesis, whereas its suppression colon cells decreased motility....
Cancer-microbe associations have been explored for centuries, but cancer-associated fungi rarely examined. Here, we comprehensively characterize the cancer mycobiome within 17,401 patient tissue, blood, and plasma samples across 35 types in four independent cohorts. We report fungal DNA cells at low abundances many major human cancers, with differences community compositions that differ among types, even when accounting technical background. Fungal histological staining of tissue microarrays...
Abstract Cancer cells become metastatic by acquiring a motile and invasive phenotype. This step requires remodeling of the actin cytoskeleton expression exploratory, sensory organelles known as filopodia. Aberrant β-catenin-TCF target gene activation plays major role in colorectal cancer development. We identified fascin1, key component filopodia, signaling cells. Fascin1 mRNA protein were increased primary cancers stage-dependent manner. was exclusively localized at front tumors also...
Abstract L1-CAM, a neuronal cell adhesion receptor, is also expressed in variety of cancer cells. Recent studies identified L1-CAM as target gene β-catenin-T-cell factor (TCF) signaling at the invasive front human colon tissue. We found that expression cells lacking confers metastatic capacity, and mice injected their spleen with such form liver metastases. ADAM10, metalloproteinase cleaves extracellular domain, novel β-catenin-TCF signaling. ADAM10 overexpression displaying endogenous...
Objectives To resolve the controversy regarding presence of a microbiota in placenta. Design Classical and molecular microbiological study. Setting All samples were collected during caesarean section. Population A total 28 human placentas six murine placentas. Methods checked for 16S rRNA gene amplification products. Three locations from four selected three ‘environmental controls’ each placenta placed seven culture media. The further analysed using Gram stain, immunohistochemistry bacteria,...
Identifying robust, patient-specific, and predictive biomarkers presents a major obstacle in precision oncology. To optimize patient-specific therapeutic strategies, here we couple pathway knowledge with large-scale drug sensitivity, RNAi, CRISPR-Cas9 screening data from 460 cell lines. Pathway activity levels are found to be strong for the essentiality of 15 proteins, including MAD2L1 breast cancer patients high BRCA-pathway activity. We also find sensitivity 31 compounds, BCL2 microtubule...
Germline BRCA-associated pancreatic ductal adenocarcinoma (glBRCA PDAC) tumors are susceptible to platinum and PARP inhibition. The clinical outcomes of 125 patients with glBRCA PDAC were stratified based on the spectrum response platinum/PARP inhibition: (i) refractory [overall survival (OS) <6 months], (ii) durable followed by acquired resistance (OS <36 months), (iii) long-term responders >36 months). Patient-derived xenografts (PDX) generated from 25 at different time points. Response...
Hyperactivation of beta-catenin-T-cell-factor (TCF)-regulated gene transcription is a hallmark colorectal cancer (CRC). The cell-neural adhesion molecule L1CAM (hereafter referred to as L1) target beta-catenin-TCF, exclusively expressed at the CRC invasive front in humans. L1 overexpression cells increases cell growth and motility, promotes liver metastasis. Genes induced by are also human tissue but mechanisms which confers metastasis still unknown. We found that signaling nuclear factor...
// Beny Shapiro 1, * , Piera Tocci Gal Haase 1 Nancy Gavert Avri Ben-Ze'ev Department of Molecular Cell Biology, The Weizmann Institute Science, Rehovot, 76100, Israel These authors have equally contributed to this work Correspondence to: Ben-Ze'ev, e-mail: avri.ben-zeev@weizmann.ac.il Keywords: clusterin, L1, colon cancer, metastasis Received: May 12, 2015 Accepted: September 07, Published: 19, ABSTRACT Hyperactive Wnt signaling is a common feature in human colorectal cancer (CRC) cells. A...
Aberrant activation of Wnt/β-catenin signaling is common in most sporadic and inherited colorectal cancer (CRC) cells leading to elevated β-catenin/TCF transactivation. We previously identified the neural cell adhesion molecule L1 as a target gene CRC cells. Forced expression confers increased motility, invasion, tumorigenesis, induction human metastasis liver. In tissue, exclusively localized at invasive front such tumors subpopulation displaying nuclear β-catenin. determined whether...
Abstract Nr-CAM, a cell-cell adhesion molecule of the immunoglobulin-like cell family, known for its function in neuronal outgrowth and guidance, was recently identified as target gene β-catenin signaling human melanoma colon carcinoma cells tissue. Retrovirally mediated transduction Nr-CAM into fibroblasts induces motility tumorigenesis. We investigated mechanisms by which can confer properties related to tumor behavior found that expression NIH3T3 protects from apoptosis absence serum...