A5086595384- Gut microbiota and health
- Single-cell and spatial transcriptomics
- Gene Regulatory Network Analysis
- Bioinformatics and Genomic Networks
- Gestational Diabetes Research and Management
- Metabolomics and Mass Spectrometry Studies
- Evolutionary Game Theory and Cooperation
- Cancer Cells and Metastasis
- Plant and animal studies
- Cancer Research and Treatments
- Plant tissue culture and regeneration
- Diet and metabolism studies
- Genetics, Aging, and Longevity in Model Organisms
- Quantum Mechanics and Non-Hermitian Physics
- Cell Image Analysis Techniques
- Complex Network Analysis Techniques
- Stochastic processes and statistical mechanics
- Cancer Genomics and Diagnostics
- Food Security and Health in Diverse Populations
- Topological Materials and Phenomena
- Quantum many-body systems
- Fungal Biology and Applications
- Opinion Dynamics and Social Influence
Bar-Ilan University
2018-2023
Open University of Israel
2022-2023
Cancer-microbe associations have been explored for centuries, but cancer-associated fungi rarely examined. Here, we comprehensively characterize the cancer mycobiome within 17,401 patient tissue, blood, and plasma samples across 35 types in four independent cohorts. We report fungal DNA cells at low abundances many major human cancers, with differences community compositions that differ among types, even when accounting technical background. Fungal histological staining of tissue microarrays...
Abstract Keystone taxa in ecological communities are native that play an especially important role the stability of their ecosystem. However, we still lack effective framework for identifying these from available high-throughput sequencing without notoriously difficult step reconstructing detailed network inter-specific interactions. In addition, while most microbial interaction models assume pair-wise relationships, it is yet unclear whether interactions dominate system, or higher-order...
We study the emergence of a giant component in spatial network where nodes form fractal set, and interaction between has long-range power-law behavior. The are positioned metric space using L\`evy flight procedure, with an associated scale-invariant step probability density function, that is then followed by process connecting each pair depends on distance them. Since sequentially, we able to calculate for edge any two terms their indexes map model problem percolation one-dimensional lattice...
Gestational Diabetes Mellitus (GDM), a serious complication during pregnancy which is defined by abnormal glucose regulation, commonly treated diabetic diet and lifestyle changes. While recent findings place the microbiome as natural mediator between interventions diverse disease states, its role in GDM still unknown. Here, based on observation data from healthy pregnant control group patients, we developed new network approach using patterns of co-abundance microorganism to construct...
Topological properties of Harper and generalized Fibonacci chains are studied in crystalline cases, i.e., for rational values the modulation frequency. The crystals at fixed frequency connected by an interpolating one-parameter Hamiltonian. As parameter is varied, one observes topological phase transitions, changes Chern integers two bands due to degeneracy these some value. For small frequency, corresponding a semiclassical regime, degeneracies shown occur when average energy approximately...
Abstract Genes are linked by underlying regulatory mechanisms and jointly implementing biological functions, working in coordination to apply different tasks the cells. Assessing level between genes from single-cell transcriptomic data, without a priori knowledge of map gene interactions, is challenge. A ‘top-down’ approach has recently been developed analyze data evaluating global (called GCL). Here, we systematically performance GCL typical scenarios RNA sequencing (scRNA-seq) data. We...
Abstract Recent technological advances, such as single-cell RNA sequencing (scRNA-seq), allow the measurement of gene expression profiles individual cells. These typically exhibit substantial variations even across seemingly homogeneous populations Two main different sources contribute to this measured variability: actual differences between biological activity cells and technical errors. Analysis variability may provide information about underlying regulation cells, yet distinguishing it...
Abstract Keystone species in ecological communities are native that play an especially important role the stability of their ecosystem and can also be potentially used as its main drivers. However, we still lack effective framework for identifying these from available metagenomic data without notoriously difficult step reconstructing detailed network inter-specific interactions. Here propose a top-down identification framework, which detects keystones by total influence on rest species. Our...
Abstract While the study of tumor microbiome and its effects on cancer biology has expanded considerably over last few years, most this research focused bacteria viruses, leaving behind fungal kingdom. Recently, a studies have demonstrated that specific fungi may promote progression, stressing importance comprehensively studying mycobiome effects. To address this, we characterized in 1,183 human tumors their adjacent tissues, originating from eight major solid types. Staining imaging...
May’s stability theory [1, 2], which holds that large ecosystems can be stable up to a critical level of complexity, product the number resident species and intensity their interactions, has been central paradigm in theoretical ecology [3–7]. So far, however, empirically demonstrating this real ecological systems long-standing challenge, with inconsistent results [8]. Especially, it is unknown whether pertinent rich complex communities natural microbiomes, mainly due challenge reliably...
Abstract Gestational Diabetes Mellitus (GDM), a serious complication during pregnancy which is defined by abnormal glucose regulation, commonly treated diabetic diet and lifestyle changes. While recent findings place the microbiome as natural mediator between interventions diverse disease states, its role in GDM still unknown. Here, based on observation data from healthy pregnant control group patients, we developed new network approach using patterns of co-abundance microorganism to...