A5001901842- Gut microbiota and health
- Cancer Cells and Metastasis
- Probiotics and Fermented Foods
- Cancer, Hypoxia, and Metabolism
- Antifungal resistance and susceptibility
- Cancer Research and Treatments
- Angiogenesis and VEGF in Cancer
- Nanoplatforms for cancer theranostics
- Lung Cancer Research Studies
- Fungal Biology and Applications
Nucleix (Israel)
2024
Weizmann Institute of Science
2013-2024
Cancer-microbe associations have been explored for centuries, but cancer-associated fungi rarely examined. Here, we comprehensively characterize the cancer mycobiome within 17,401 patient tissue, blood, and plasma samples across 35 types in four independent cohorts. We report fungal DNA cells at low abundances many major human cancers, with differences community compositions that differ among types, even when accounting technical background. Fungal histological staining of tissue microarrays...
The mycobiota are a critical part of the gut microbiome, but host–fungal interactions and specific functional contributions commensal fungi to host fitness remain incompletely understood. Here, we report identification new fungal commensal, Kazachstania heterogenica var. weizmannii, isolated from murine intestines. K. weizmannii exposure prevented Candida albicans colonization significantly reduced C. burden in colonized animals. Following immunosuppression mice, competitive commensalism...
Abstract The mycobiota are a critical part of the gut microbiome, but host-fungal interactions and specific functional contributions commensal fungi to host fitness remain incompletely understood. Here we report identification new fungal commensal, Kazachstania heterogenica var. weizmannii, isolated from murine intestines. K. weizmannii exposure prevented Candida albicans colonization significantly reduced C. burden in colonized animals. Following immunosuppression mice, competitive...
Metastatic ovarian cancer, the most lethal of gynecologic malignancies, is typically managed by debulking surgery, followed chemotherapy. However, despite significant efforts, survival rate remains low. We have previously demonstrated, in mouse models, a specific systemic homing labeled fibroblasts to solid tumors. Here, we demonstrate feasibility utilizing this genetically modified for detection and targeted therapy orthotopic metastatic carcinoma model immune-deficient mice. Using an vivo...
Abstract While the study of tumor microbiome and its effects on cancer biology has expanded considerably over last few years, most this research focused bacteria viruses, leaving behind fungal kingdom. Recently, a studies have demonstrated that specific fungi may promote progression, stressing importance comprehensively studying mycobiome effects. To address this, we characterized in 1,183 human tumors their adjacent tissues, originating from eight major solid types. Staining imaging...