A5102791061- Inflammasome and immune disorders
- Immune cells in cancer
- Immune Response and Inflammation
- Osteomyelitis and Bone Disorders Research
- Protein Tyrosine Phosphatases
- Immunotherapy and Immune Responses
- Probiotics and Fermented Foods
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Gut microbiota and health
- Oxidative Organic Chemistry Reactions
- Antifungal resistance and susceptibility
- Telomeres, Telomerase, and Senescence
- Synthetic Organic Chemistry Methods
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- Catalytic Alkyne Reactions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Single-cell and spatial transcriptomics
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- RNA Interference and Gene Delivery
- Porphyrin and Phthalocyanine Chemistry
- Eosinophilic Disorders and Syndromes
- Immune responses and vaccinations
- Cytokine Signaling Pathways and Interactions
Weizmann Institute of Science
2023-2024
Czech Academy of Sciences, Institute of Molecular Genetics
2015-2024
Melodea (Israel)
2023
Institute of Molecular Genetics
2018
Charles University
2011-2018
The accumulation of senescent cells promotes ageing and age-related diseases, but molecular mechanisms that use to evade immune clearance accumulate in tissues remain be elucidated. Here we report p16-positive upregulate the checkpoint protein programmed death-ligand 1 (PD-L1) chronic inflammation. We show p16-mediated inhibition cell cycle kinases CDK4/6 induces PD-L1 stability via downregulation its ubiquitin-dependent degradation. p16-expressing alveolar macrophages elevate promote an...
The mycobiota are a critical part of the gut microbiome, but host–fungal interactions and specific functional contributions commensal fungi to host fitness remain incompletely understood. Here, we report identification new fungal commensal, Kazachstania heterogenica var. weizmannii, isolated from murine intestines. K. weizmannii exposure prevented Candida albicans colonization significantly reduced C. burden in colonized animals. Following immunosuppression mice, competitive commensalism...
Abstract Mutations in the adaptor protein PSTPIP2 are cause of autoinflammatory disease chronic multifocal osteomyelitis mice. This closely resembles human disorder recurrent osteomyelitis, characterized by sterile inflammation bones and often associated with other organs, such as skin. The most critical process disease’s development is enhanced production IL-1β. excessive IL-1β likely produced neutrophils. In addition, increased activity macrophages, osteoclasts, megakaryocytes has also...
LST1 is a small adaptor protein expressed in leukocytes of myeloid lineage. Due to the binding tyrosine phosphatases SHP1 and SHP2 it was thought have negative regulatory function leukocyte signaling. It also shown be involved cytoskeleton regulation generation tunneling nanotubes. gene located MHCIII locus close many immunologically relevant genes. In addition, its expression increases under inflammatory conditions such as viral infection, rheumatoid arthritis bowel disease deficiency...
Abstract The accumulation of senescent cells promotes aging, but a molecular mechanism that use to evade immune clearance and accumulate remains be elucidated. Here, we report p16-positive upregulate the checkpoint protein programmed death-ligand 1 (PD-L1) in aging chronic inflammation. p16-mediated inhibition CDK4/6 PD-L1 stability via downregulation ubiquitin-dependent degradation. p16 expression infiltrating macrophages induces an immunosuppressive environment can contribute increased...
Dihydropyrans have been prepared by the cyclisation of easily accessible propargyl vinyl ethers with (TFP)AuCl/AgBF4 as a catalyst in high yields. These compounds undergo acid-catalysed rearrangement into cyclopentenone derivatives.
Abstract The mycobiota are a critical part of the gut microbiome, but host-fungal interactions and specific functional contributions commensal fungi to host fitness remain incompletely understood. Here we report identification new fungal commensal, Kazachstania heterogenica var. weizmannii, isolated from murine intestines. K. weizmannii exposure prevented Candida albicans colonization significantly reduced C. burden in colonized animals. Following immunosuppression mice, competitive...
WW domain binding protein 1-like (WBP1L), also known as outcome predictor of acute leukemia 1 (OPAL1), is a transmembrane adaptor protein, expression which was shown to correlate with ETV6-RUNX1 translocation and favorable prognosis in childhood leukemia. It has broad pattern hematopoietic non-hematopoietic cells. Our previous work described WBP1L regulator CXCR4 signaling hematopoiesis. Here, we show that hematopoiesis the mice
WW domain binding protein 1-like (WBP1L), also known as outcome predictor of acute leukaemia 1 (OPAL1), is a transmembrane adaptor protein, expression which correlates with ETV6-RUNX1 (t(12;21)(p13;q22)) translocation and favourable prognosis in childhood leukaemia. It has broad pattern haematopoietic non-haematopoietic cells. However, its physiological function been unknown. Here, we show that WBP1L negatively regulates signalling through critical chemokine receptor CXCR4 multiple leucocyte...
Dendritic cells and macrophages are crucial that form the first line of defense against pathogens. They also play important roles in initiation an adaptive immune response. Experimental work with these is rather challenging. Their abundance organs tissues relatively low. As a result, they cannot be isolated large numbers. difficult to transfect cDNA constructs. In murine model, problems can partially overcome by vitro differentiation from bone marrow progenitors presence M-CSF for or GM-CSF...
Abstract Monocytes are short-lived myeloid immune cells that arise from adult hematopoiesis and circulate for a short time in the blood. They comprise two main subsets, mice defined as classical Ly6C high non-classical low monocytes (CM, NCM). Recent fate mapping transcriptomic analyses revealed CM themselves heterogeneous. Here, we report surface markers allow segregation of murine GMP- MDP-derived BM Functional characterization, including definition following adoptive cell transfer,...
Abstract Autoinflammatory diseases are characterized by dysregulation of the innate immune system, leading to spontaneous inflammation. Pstpip2cmo mouse strain is a well-characterized model this class disorders. Because mutation lack adaptor protein PSTPIP2, these animals suffer from autoinflammatory chronic multifocal osteomyelitis similar several human syndromes. Current evidence suggests that it driven hyperproduction IL-1β neutrophil granulocytes. In study, we show in addition IL-1β,...
A number of human autoinflammatory diseases manifest with severe inflammatory bone destruction. Mouse models these represent valuable tools that help us to understand molecular mechanisms triggering this autoinflammation. The Pstpip2cmo mouse strain is among the best characterized these; it harbors a mutation resulting in loss adaptor protein PSTPIP2 and development osteomyelitis. In mice, overproduction interleukin-1β (IL-1β) reactive oxygen species by neutrophil granulocytes leads...
Autoinflammatory diseases are characterized by dysregulation of innate immune system leading to spontaneous sterile inflammation. One the well-established animal models this group disorders is mouse strain Pstpip2cmo . In strain, loss adaptor protein PSTPIP2 leads autoinflammatory disease chronic multifocal osteomyelitis. It manifested inflammation bones and surrounding soft tissues hind limbs tail. The development propelled elevated production IL-1β reactive oxygen species neutrophil...
Kazachstania heterogenica is a member of the K. telluris complex, where all members to date are reported be pathogenic fungi. We have isolated strain, var. weizmannii, from gut mice that seems commensal strain and sequenced its genome.
Abstract The cyclization of the easily accessible compounds (I) to dihydropyrans (III) which undergo an acid catalyzed unprecedented rearrangement (IV)‐(VI) is presented.
Abstract Autoinflammatory diseases are characterized by dysregulation of the innate immune system leading to spontaneous inflammation. Pstpip2 cmo mouse strain is a well-characterized model this class disorders. Due mutation lack adaptor protein PSTPIP2, these animals suffer from autoinflammatory chronic multifocal osteomyelitis similar several human syndromes. Current evidence suggests that it driven hyperproduction IL-1β neutrophil granulocytes. Here we show in addition IL-1β, PSTPIP2 also...
Abstract Photodynamic therapy (PDT) has attracted great attention in cancer treatment. Porphyrin derivative with ethylene glycol chains linked to meta position of meso-tetraphenylporphyrin, mTPP(EG)4, is one assumed compounds that can be used for treatment photodynamic (PDT). The aim the study demonstrate efficacy vitro and vivo as well analyze its therapeutic mechanism. cell viability, surface exposure immunogenic molecules, maturation phagocytic capacity PDT-treated tumor cells were...