A5073361648- Gut microbiota and health
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
- Cancer Cells and Metastasis
- Antifungal resistance and susceptibility
- Probiotics and Fermented Foods
- Genomics and Phylogenetic Studies
- Mass Spectrometry Techniques and Applications
- RNA modifications and cancer
- Cancer Research and Treatments
- Microbial Metabolic Engineering and Bioproduction
- Bacteriophages and microbial interactions
- Evolution and Genetic Dynamics
- Fungal Biology and Applications
- Machine Learning in Bioinformatics
- Genomics and Rare Diseases
- Advanced Proteomics Techniques and Applications
Weizmann Institute of Science
2016-2024
Nucleix (Israel)
2024
Cancer-microbe associations have been explored for centuries, but cancer-associated fungi rarely examined. Here, we comprehensively characterize the cancer mycobiome within 17,401 patient tissue, blood, and plasma samples across 35 types in four independent cohorts. We report fungal DNA cells at low abundances many major human cancers, with differences community compositions that differ among types, even when accounting technical background. Fungal histological staining of tissue microarrays...
The mycobiota are a critical part of the gut microbiome, but host–fungal interactions and specific functional contributions commensal fungi to host fitness remain incompletely understood. Here, we report identification new fungal commensal, Kazachstania heterogenica var. weizmannii, isolated from murine intestines. K. weizmannii exposure prevented Candida albicans colonization significantly reduced C. burden in colonized animals. Following immunosuppression mice, competitive commensalism...
Each stage of the Central Dogma contributes to proteome diversity through mechanisms such as heterozygosity, somatic mutations, transcriptional errors, and translational errors. As a result, diverse array protein variants can coexist within single proteome, that humans. However, until now, methods detect, quantify, evaluate functional consequences these have been lacking. Here we examined large-scale proteogenomic dataset from 29 healthy human tissues uncovered over 46,000 unique amino acid...
Tracing evolutionary processes that lead to fixation of genomic variation in wild bacterial populations is a prime challenge molecular evolution. In particular, the relative contribution horizontal gene transfer (HGT)
Abstract The mycobiota are a critical part of the gut microbiome, but host-fungal interactions and specific functional contributions commensal fungi to host fitness remain incompletely understood. Here we report identification new fungal commensal, Kazachstania heterogenica var. weizmannii, isolated from murine intestines. K. weizmannii exposure prevented Candida albicans colonization significantly reduced C. burden in colonized animals. Following immunosuppression mice, competitive...
Abstract While the study of tumor microbiome and its effects on cancer biology has expanded considerably over last few years, most this research focused bacteria viruses, leaving behind fungal kingdom. Recently, a studies have demonstrated that specific fungi may promote progression, stressing importance comprehensively studying mycobiome effects. To address this, we characterized in 1,183 human tumors their adjacent tissues, originating from eight major solid types. Staining imaging...