A5040057015- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cellular Mechanics and Interactions
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Pluripotent Stem Cells Research
- Probiotics and Fermented Foods
- Neurofibromatosis and Schwannoma Cases
- Cancer-related gene regulation
- Animal Genetics and Reproduction
- Evolutionary Game Theory and Cooperation
- Mass Spectrometry Techniques and Applications
- Meat and Animal Product Quality
- 3D Printing in Biomedical Research
- Cell Image Analysis Techniques
- Signaling Pathways in Disease
- Cancer Mechanisms and Therapy
- Evolution and Genetic Dynamics
- Genomics and Phylogenetic Studies
- Protein Hydrolysis and Bioactive Peptides
- Hippo pathway signaling and YAP/TAZ
- Axon Guidance and Neuronal Signaling
Agricultural Research Organization
2021-2024
Weizmann Institute of Science
2018-2021
Tel Aviv University
2012-2016
The tRNA pool determines the efficiency, throughput, and accuracy of translation. Previous studies have identified dynamic changes in (transfer RNA) supply mRNA (messenger demand during cancerous proliferation. Yet may also occur physiologically normal proliferation, these are less well characterized. We examined pools T cells their vigorous proliferation differentiation upon triggering antigen receptor. observed a global signature switch for codons at early phase response, accompanied by...
The cultivation of meat using in vitro grown animal stem cells offers a promising solution to pressing global concerns around climate change, ethical considerations, and public health. However, cultivated introduces an unprecedented necessity: the generation mass scales cellular biomaterial, achieved by fostering cell proliferation within bioreactors. Existing methods for encounter substantial challenges terms both scalability economic viability. Within this perspective, we discuss current...
Codon usage bias affects protein translation because tRNAs that recognize synonymous codons differ in their abundance. Although the current dogma states tRNA expression is exclusively regulated by intrinsic control elements (A- and B-box sequences), we revealed, using a reporter monitors levels of individual genes Caenorhabditis elegans, eight tryptophan genes, 100% identical sequence, are expressed different tissues change dynamically. Furthermore, sup-7 gene at day 6 were found to predict...
Efrat Mashiach-Farkash *,1 , Roni Rak *,3 Galit Elad-Sfadia 3 Haklai Shmuel Carmeli 2 Yoel Kloog and Haim J. Wolfson 1 The Blavatnik School of Computer Science, Raymond Beverly Sackler Faculty Exact Sciences, Tel-Aviv University, Tel Aviv, Israel Chemistry, Department Neurobiology, George S. Wise Life * denotes equal contributors Received: June 21, 2012; Accepted: July 06, Published: 07, Keywords: Cofilin, Ras, Rac, Rho, LIMK. Abbreviations: ADF, actin-depolymerizing factor; CSRD,...
In experimental evolution, scientists evolve organisms in the lab, typically by challenging them to new environmental conditions. How best a desired trait? Should challenge be applied abruptly, gradually, periodically, sporadically? one apply chemical mutagenesis, and do strains with high innate mutation rate faster? What are ideal population sizes of evolving populations? There endless strategies, beyond those that can exposed individual labs. We therefore arranged community challenge,...
Different subsets of the tRNA pool in human cells are expressed different cellular conditions. The 'proliferation-tRNAs' induced upon normal and cancerous cell division, while 'differentiation-tRNAs' active non-dividing, differentiated cells. Here we examine essentiality various tRNAs growth arrest. We established a CRISPR-based editing procedure with sgRNAs that each target family. measured for found most proliferation-tRNAs essential compared to differentiation- rapidly growing lines. Yet...
LIM kinases (LIMKs) are important cell cytoskeleton regulators that play a prominent role in cancer manifestation and neuronal diseases.The LIMK family consists of two homologues, LIMK1 LIMK2, which differ from one another expression profile, intercellular localization, function.The main substrate is cofilin, member the actin-depolymerizing factor (ADF) protein family.When phosphorylated by LIMK, cofilin inactive.LIMKs contributory several neurodevelopmental disorders growth metastasis.We...
Abstract The tRNA pool determines the efficiency, throughput, and accuracy of translation. Previous studies have identified dynamic changes in supply mRNA demand during cancerous proliferation. Yet, may occur also physiologically normal proliferation, these are less characterized. We examined pools T-cells their vigorous proliferation differentiation upon triggering antigen receptor. observe a global signature switch for codons at early phase response, accompanied by corresponding expression...
Abstract Different subsets of the tRNA pool in human are expressed different cellular conditions. The “proliferation-tRNAs” induced upon normal and cancerous cell division, while “differentiation tRNAs” active non-dividing, differentiated cells. Here we examine essentiality various tRNAs growth arrest. We established a CRISPR-based editing procedure with sgRNAs that each target family. measured for found most proliferation essential compared to differentiation rapidly growing lines. Yet more...