A5052068951- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- PARP inhibition in cancer therapy
- Cancer Immunotherapy and Biomarkers
- Bone health and treatments
- Renal cell carcinoma treatment
- CAR-T cell therapy research
- Ferroptosis and cancer prognosis
- Genetic factors in colorectal cancer
- Single-cell and spatial transcriptomics
- Phagocytosis and Immune Regulation
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Mitochondrial Function and Pathology
- Gut microbiota and health
- Cancer Cells and Metastasis
- Advanced biosensing and bioanalysis techniques
- Glaucoma and retinal disorders
- Effects of Radiation Exposure
- Colorectal Cancer Treatments and Studies
- Cancer, Lipids, and Metabolism
- Immunotherapy and Immune Responses
- Spectroscopy Techniques in Biomedical and Chemical Research
Stanford University
2024-2025
University of Michigan–Ann Arbor
2024-2025
Ontario Institute for Cancer Research
2017-2024
Yale University
2020-2024
Center for Neurosciences
2024
Indiana University – Purdue University Indianapolis
2014-2024
National Institutes of Health
2019-2024
Indiana University Indianapolis
2024
Institute of Cancer Research
2017-2024
Princess Margaret Cancer Centre
2023
Purpose: To perform real-time whole genome sequencing (WGS) and RNA (RNASeq) of advanced pancreatic ductal adenocarcinoma (PDAC) to identify predictive mutational transcriptional features for better treatment selection.Experimental Design: Patients with PDAC were prospectively recruited prior first-line combination chemotherapy. Fresh tumor tissue was acquired by image-guided percutaneous core biopsy WGS RNASeq. Laser capture microdissection performed all cases. Primary endpoint feasibility...
Abstract Purpose: To determine the impact of basal-like and classical subtypes in advanced pancreatic ductal adenocarcinoma (PDAC) to explore GATA6 expression as a surrogate biomarker. Experimental Design: Within COMPASS trial, patients proceeding chemotherapy for PDAC undergo tumor biopsy RNA-sequencing (RNA-seq). Overall response rate (ORR) overall survival (OS) were stratified by according received. Correlation with using gene profiling, situ hybridization (ISH) was explored. Results:...
Although p53 inactivation promotes genomic instability
Abstract The most prominent homozygous deletions in cancer affect chromosome 9p21.3 and eliminate CDKN2A/B tumor suppressors, disabling a cell-intrinsic barrier to tumorigenesis. Half of deletions, however, also encompass type I interferon (IFN) gene cluster; the consequences this co-deletion remain unexplored. To functionally dissect other large genomic we developed flexible deletion engineering strategy, MACHETE (molecular alteration chromosomes with engineered tandem elements). Applying...
The molecular drivers of antitumor immunity in pancreatic ductal adenocarcinoma (PDAC) are poorly understood, posing a major obstacle for the identification patients potentially amenable immune-checkpoint blockade or other novel strategies. Here, we explore association chemokine expression with effector T-cell infiltration PDAC.Discovery cohorts comprised 113 primary resected PDAC and 107 liver metastases. Validation 182 from Cancer Genome Atlas 92 PDACs Australian International Consortium....
Abstract The degree of metastatic disease varies widely among patients with cancer and affects clinical outcomes. However, the biological functional differences that drive extent metastasis are poorly understood. We analyzed primary tumors paired metastases using a multifluorescent lineage-labeled mouse model pancreatic ductal adenocarcinoma (PDAC)—a tumor type in which most present metastases. Genomic transcriptomic analysis revealed an association between burden gene amplification or...
Germline BRCA-associated pancreatic ductal adenocarcinoma (glBRCA PDAC) tumors are susceptible to platinum and PARP inhibition. The clinical outcomes of 125 patients with glBRCA PDAC were stratified based on the spectrum response platinum/PARP inhibition: (i) refractory [overall survival (OS) <6 months], (ii) durable followed by acquired resistance (OS <36 months), (iii) long-term responders >36 months). Patient-derived xenografts (PDX) generated from 25 at different time points. Response...
Abstract Reported is a new shell‐based spectroscopic platform, named mechanical trap surface‐enhanced Raman spectroscopy (MTSERS), for simultaneous capture, profiling, and 3D microscopic mapping of the intrinsic molecular signatures on membrane single live cells. By leveraging functionalization inner surfaces MTs with plasmonic gold nanostars, conformal contact cell membrane, MTSERS permits excellent signal enhancement, reliably detects signatures, allows non‐perturbative, multiplex surface...
While localized prostate cancer (PCa) can be effectively cured, metastatic disease inevitably progresses to a lethal state called castration-resistant (CRPC). Emerging evidence suggests that aberrant epigenetic repression by the polycomb group (PcG) complexes fuels PCa progression, providing novel therapeutic opportunities.In search for potential drivers of CRPC, we analyzed molecular profile PcG members in patient-derived xenografts and clinical samples. Overall, our results identify...
Thyroid disorders have emerged as one of the most common immune-related adverse events (irAE), yet optimum management and biomarkers to predict vulnerable individuals remain be explored. High-dose glucocorticoid (HDG) therapy is routinely recommended for irAEs. However, systematic analysis impact on outcome immune-checkpoint inhibitor (ICI)-induced thyroid lacking. We analyzed 151 patients with or without ICI-related disorders. divided into two subgroups: those HDG treatment. Our results...
To describe the clinical, pathological and genomic characteristics of pancreatic cancer with DNA mismatch repair deficiency (MMRD) proficiency (MMRP).We identified patients MMRD MMRP in a clinical cohort (N=1213, 519 genetic testing, 53 immunohistochemistry (IHC)) (N=288 whole-genome sequencing (WGS)).12 out 1213 (1.0%) were by IHC or WGS. Of 14 Lynch syndrome, 3 (21.4%) had an IHC, 4 (28.6%) excluded because tissue was unavailable for testing. cancers longer overall survival after surgery...
Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis among solid malignancies and improved therapeutic strategies are needed to improve outcomes. Patient-derived xenografts (PDX) patient-derived organoids (PDO) serve as promising tools identify new drugs with potential in PDAC. For these preclinical disease models be effective, they should both recapitulate molecular heterogeneity of PDAC validate patient-specific sensitivities. To date however, deep characterization PDX PDO...
Abstract Pancreatic cancer metastasis is a leading cause of cancer-related deaths, yet very little understood regarding the underlying biology. As result, targeted therapies to inhibit are lacking. Here, we report that parathyroid hormone–related protein (PTHrP encoded by PTHLH) frequently amplified as part KRAS amplicon in patients with pancreatic cancer. PTHrP upregulation drives growth both primary and metastatic tumors mice highly enriched ductal adenocarcinoma metastases. Loss...
Reward and representation learning are two long-standing challenges for an expanding set of robot manipulation skills from sensory observations. Given the inherent cost scarcity in-domain, task-specific data, large, diverse, offline human videos has emerged as a promising path towards acquiring generally useful visual control; however, how these can be used general-purpose reward remains open question. We introduce $\textbf{V}$alue-$\textbf{I}$mplicit $\textbf{P}$re-training (VIP),...
Nucleoporins (nups) in the nuclear pore complex (NPC) form a selective barrier that suppresses diffusion of most macromolecules while enabling rapid transport receptor (NTR)–bound cargos. Recent studies have shown NPC may dilate and constrict, but how altering diameter affects its properties remains unclear. Here, we build DNA nanopores with programmable diameters nup arrangements to model constricted dilated NPCs. We find Nup62 proteins dynamic cross-channel impermeable hepatitis B virus...
Precis: Current optical coherence tomography normative sample data may not represent diverse human optic nerve anatomy to accurately classify all individuals with true glaucomatous neuropathy. Purpose: To compare head (ONH) measurements between published values from an (OCT) database and a more cohort of healthy individuals. Patients Methods: ONH parameters participants the Michigan Screening Intervention for Glaucoma Eye Health through Telemedicine (MI-SIGHT) program Topcon Maestro-1 were...
Commensals shape host physiology through molecular crosstalk with receptors. Identifying specific microbial factors that causally influence immunity is key to understanding homeostasis at the host-microbe interface and advancing microbial-based therapeutics. Here, we identify trehalose monocorynomycolate (TMCM) from Corynebacterium mastitidis ( C. mast ) as a potent stimulator of IL-17 production by γδ T cells ocular surface. Mechanistically, TMCM-driven responses require both IL-1 signals...