Sheng‐Ben Liang
A5032074703- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- Genetic factors in colorectal cancer
- Genomics and Chromatin Dynamics
- Genomics and Phylogenetic Studies
- Cancer-related gene regulation
- Kruppel-like factors research
- Bioinformatics and Genomic Networks
- Evolution and Genetic Dynamics
- Metabolism, Diabetes, and Cancer
- Cancer Treatment and Pharmacology
- Multiple Myeloma Research and Treatments
- Cancer-related Molecular Pathways
- Wnt/β-catenin signaling in development and cancer
- Virus-based gene therapy research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Chromosomal and Genetic Variations
- Protein Degradation and Inhibitors
- Genomics and Rare Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
University Health Network
2005-2025
Princess Margaret Cancer Centre
2006-2024
Toronto General Hospital
2020-2023
Princess Margaret Hospital
2023
The University of Texas MD Anderson Cancer Center
2020
University of Toronto
2015-2018
Ontario Institute for Cancer Research
2002-2007
Cancer Institute (WIA)
2007
Kochi Medical School Hospital
1998-2002
Purpose: To perform real-time whole genome sequencing (WGS) and RNA (RNASeq) of advanced pancreatic ductal adenocarcinoma (PDAC) to identify predictive mutational transcriptional features for better treatment selection.Experimental Design: Patients with PDAC were prospectively recruited prior first-line combination chemotherapy. Fresh tumor tissue was acquired by image-guided percutaneous core biopsy WGS RNASeq. Laser capture microdissection performed all cases. Primary endpoint feasibility...
The molecular drivers of antitumor immunity in pancreatic ductal adenocarcinoma (PDAC) are poorly understood, posing a major obstacle for the identification patients potentially amenable immune-checkpoint blockade or other novel strategies. Here, we explore association chemokine expression with effector T-cell infiltration PDAC.Discovery cohorts comprised 113 primary resected PDAC and 107 liver metastases. Validation 182 from Cancer Genome Atlas 92 PDACs Australian International Consortium....
Abstract Epigenetic therapies facilitate transcription of immunogenic repetitive elements that cull cancer cells through ‘viral mimicry’ responses. Paradoxically, cancer-initiating events also elements. Contributions element towards initiation, and the mechanisms by which evade lethal viral mimicry responses during tumor initiation remain poorly understood. In this report, we characterize premalignant lesions fallopian tube along with syngeneic epithelial ovarian models to explore earliest...
Abstract: In the present study, we first examined expression of T‐cadherin in human CNS by northern blot analysis, immunohistochemical staining, and situ hybridization. Northern analysis demonstrated adult cerebral cortex, medulla, thalamus, midbrain. Immunohistochemical staining with a newly generated monoclonal antibody, designated MA‐511, revealed strong neural cell surface membrane neurites medulla oblongata, nucleus olivaris. Little or no was found spinal cord. We further various...
<p>Figure S2 shows that Trp53 mutation facilitates transcriptional dysregulation of retrotransposons in murine oviductal epithelial cells and ovarian surface cells.</p>
<p>Table S1: Patient cohort characteristics</p>
<p>Figure S1 Shows that TP53 mutation facilitates transcriptional dysregulation of retrotransposons in STICs and human fallopian tube secretory epithelial cells</p>
<p>Figure S4 shows that p53 loss increases cytosolic accumulation of RNA:DNA and dsRNA</p>
<p>Table S2: Guide RNAs used for CRISPR gene editing in this study</p>
<div>Abstract<p>Epigenetic therapies facilitate transcription of immunogenic repetitive elements that cull cancer cells through “viral mimicry” responses. Paradoxically, cancer-initiating events also elements. Contributions element toward initiation, and the mechanisms by which evade lethal viral mimicry responses during tumor initiation remain poorly understood. In this report, we characterize premalignant lesions fallopian tube along with syngeneic epithelial ovarian models to...
<p>Table S3: Antibodies used in this study</p>
<p>Figure S7 that shows the impact of viral mimicry conditioning on therapeutic approaches</p>
<p>Figure S6 that shows Acquisition of viral mimicry tolerance affects antitumor adaptive immune responses</p>
<p>Figure S5 that shows Viral mimicry conditioning diminishes Type I IFN</p>
<p>Figure S3 shows that p53 loss diminishes H3K9me3 at transcriptionally upregulated repetitive elements</p>
<p>Table S4: Primer sequences used in this study</p>
Ki-67 is a nuclear protein associated with proliferation, and strong potential biomarker in breast cancer, but not routinely measured current clinical management owing to lack of standardization. Digital image analysis (DIA) promising technology that could allow high-throughput There dearth data on the reliability as well intra- interalgorithmic variability different DIA methods. In this study, we scored compared set cancer cases which manually counted has already been demonstrated have...
Abstract T‐cadherin appears to act as a tumor‐suppressor factor in various cancers. Downregulation of is caused by combination allelic loss and hypermethylation the promoter region related cancer invasion. To elucidate molecular mechanism invasiveness basal cell carcinoma skin, expression was investigated archival pathological tissue sections made up normal counterparts skin types carcinoma. Immunohistochemical staining showed that not expressed 38 51 (75%) specimens, whereas appeared...
Expressions of p53 protein and epidermal growth factor receptor (EGFR) were immunohistochemically investigated in 111 patients with papillary thyroid carcinomas (PTC) order to evaluate their co-expression relation lymph node metastases (LNM), tumor size clinicopathologic stage. In PTC, positive staining for dewaxed sections was present nuclei or cytoplasm, both, whereas surface linear cytoplasmic EGFR observed varying degrees extent intensity. Positive reaction (more than 10% cells positive)...