Felipe Campos de Almeida
A5036273473- Virus-based gene therapy research
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Eosinophilic Disorders and Syndromes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Hepatitis B Virus Studies
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Immune responses and vaccinations
- Diabetes and associated disorders
- RNA modifications and cancer
- Acute Lymphoblastic Leukemia research
- Cannabis and Cannabinoid Research
- Chronic Lymphocytic Leukemia Research
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Arts and Performance Studies
- Lymphoma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Erythrocyte Function and Pathophysiology
- T-cell and B-cell Immunology
Princess Margaret Cancer Centre
2023-2025
Universidade de São Paulo
2017-2024
University Health Network
2023
Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular
2020
Universidade Estadual de Londrina
2015-2018
Abstract Epigenetic therapies facilitate transcription of immunogenic repetitive elements that cull cancer cells through ‘viral mimicry’ responses. Paradoxically, cancer-initiating events also elements. Contributions element towards initiation, and the mechanisms by which evade lethal viral mimicry responses during tumor initiation remain poorly understood. In this report, we characterize premalignant lesions fallopian tube along with syngeneic epithelial ovarian models to explore earliest...
<p>Figure S2 shows that Trp53 mutation facilitates transcriptional dysregulation of retrotransposons in murine oviductal epithelial cells and ovarian surface cells.</p>
<p>Table S1: Patient cohort characteristics</p>
<p>Figure S1 Shows that TP53 mutation facilitates transcriptional dysregulation of retrotransposons in STICs and human fallopian tube secretory epithelial cells</p>
<p>Figure S4 shows that p53 loss increases cytosolic accumulation of RNA:DNA and dsRNA</p>
<p>Table S2: Guide RNAs used for CRISPR gene editing in this study</p>
<div>Abstract<p>Epigenetic therapies facilitate transcription of immunogenic repetitive elements that cull cancer cells through “viral mimicry” responses. Paradoxically, cancer-initiating events also elements. Contributions element toward initiation, and the mechanisms by which evade lethal viral mimicry responses during tumor initiation remain poorly understood. In this report, we characterize premalignant lesions fallopian tube along with syngeneic epithelial ovarian models to...
<p>Table S3: Antibodies used in this study</p>
<p>Figure S7 that shows the impact of viral mimicry conditioning on therapeutic approaches</p>
<p>Figure S6 that shows Acquisition of viral mimicry tolerance affects antitumor adaptive immune responses</p>
<p>Figure S5 that shows Viral mimicry conditioning diminishes Type I IFN</p>
<p>Figure S3 shows that p53 loss diminishes H3K9me3 at transcriptionally upregulated repetitive elements</p>
<p>Table S4: Primer sequences used in this study</p>
CXCR4 genetic polymorphisms, as well their expression level, have been associated with cancer development and prognosis. The present study aimed to investigate the influence of rs2228014 polymorphism on its mRNA protein in breast samples. It was observed that patients presented higher relative (5.7-fold) than normal mammary gland, but this not correlated clinicopathological features (nuclear grade, nodal status, ER PR p53 staining, Ki67 index, HER-2 status). Moreover, also did differ...
Summary Progression to aggressive secondary acute myeloid leukaemia (sAML) poses a significant challenge in the management of myeloproliferative neoplasms (MPNs). Since physiopathology MPN is closely linked activation interferon (IFN) signalling and that AML initiation aggressiveness driven by stem cells (LSCs), we investigated these pathways sAML progression. We found high IFN correlated with low LSC samples, while progression transformation were characterized decreased increased signature....
Background The HER 2 (human epidermal growth factor receptor‐2) Ile655Val (rs1136201) genetic polymorphism can alter the receptor structure and its auto‐activation, which modify signal transduction and, consequently, cell cycle regulation. For this reason, has been extensively investigated as a candidate marker for breast cancer ( BC ). In context, aim of study was to evaluate possible influence in susceptibility prognostic factors Brazilian population. Methods Polymorphism genotype assessed...
Chronic myelogenous leukemia (CML) is a myeloproliferative neoplasm that expresses the Philadelphia chromosome and constitutively activated Bcr-Abl tyrosine kinase in hematopoietic progenitor cells. tyrosine-kinase inhibitors (TKI) do not definitively cure all CML patients. The efficacy of TKI reduced patients blastic phase-the most severe phase disease-and resistance to this drug has emerged. There limited knowledge on underlying mechanisms disease progression beyond BCR-ABL1, as well...
Efficient induction of effector and long-term protective antigen-specific CD8+ T memory response by vaccination is essential to eliminate malignant pathogen-infected cells. Intracellular infectious bacteria, including Listeria monocytogenes, have been considered potent vectors carry multiple therapeutic proteins generate cell responses. Although the role molecules involved in inflammatory death pathways, such as necroptosis (RIPK3-mediated) pyroptosis (Caspase-1/11-mediated), effectors...
Abstract Recent studies have shown that DNA methyltransferase inhibitors (DNMTi) can induce IRF7 activation and Type I/III interferon signaling through dsRNA-mediated viral mimicry in cancer cells. By performing a large pan-cancer analysis using TCGA data, we determined is associated with higher CD8+ T cell tumor infiltration cytolytic activity across multiple types. Accordingly, demonstrate DNMTi treatment results increased infiltration, enhanced dependent growth inhibition. Finally, show...
Myeloproliferative neoplasms polycythemia vera (PV), essential thrombocythaemia (ET) and primary myelofibrosis constitute a group of haematological diseases. The comprehensive assessment signaling pathway activation in blood cells may aid the understanding MPN pathophysiology. Thus, levels post-translational protein modifications total expression were determined patients control leukocytes by using reverse-phase arrays (RPPA). Compared to samples, p-SRC, p-CTNNB1, c-MYC, MCL-1, p-MDM2, BAX...