A5079438480- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- Protein Degradation and Inhibitors
- Immune cells in cancer
- Eosinophilic Disorders and Syndromes
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- Pregnancy and preeclampsia studies
- Kruppel-like factors research
- HIV/AIDS drug development and treatment
- Cancer-related gene regulation
- Glioma Diagnosis and Treatment
- Genital Health and Disease
- Neurogenetic and Muscular Disorders Research
- RNA modifications and cancer
- Acute Lymphoblastic Leukemia research
- Cancer, Stress, Anesthesia, and Immune Response
- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Intraperitoneal and Appendiceal Malignancies
Universidade de São Paulo
2017-2024
Fundação Hemopa
2021-2023
Fundação de Amparo à Pesquisa do Estado de São Paulo
2022
Celula (United States)
2021
Clinics Hospital of Ribeirão Preto
2017-2021
Fundação Faculdade de Medicina
2017
Universidade Federal do Triângulo Mineiro
2014-2015
It is increasingly becoming clear that cancers are a symbiosis of diverse cell types and tumor clones. Combined single-cell RNA sequencing, flow cytometry, immunohistochemistry studies the innate immune compartment in bone marrow patients with acute myeloid leukemia (AML) reveal shift toward tumor-supportive M2-polarized macrophage landscape an altered transcriptional program, enhanced fatty acid oxidation NAD+ generation. Functionally, these AML-associated macrophages display decreased...
Based on the fact that taurine can increase lipid metabolism, objective of present study was to evaluate effects different doses acute supplementation oxidation levels in healthy young men after a single bout fasting aerobic exercise. A double-blind, acute, and crossover design conducted. Seventeen (age 24.8 ± 4.07y; BMI: 23.9 2.57 kg/m²) participated study. Different (TAU) (3 g or 6 g) placebo were supplemented 90 min before exercise (on treadmill at 60% VO2 max). The subjects performed...
The SLIT-ROBO axis plays an important role in normal stem-cell biology, with possible repercussions on cancer stem cell emergence. Although the Promyelocytic Leukemia (PML) protein can regulate SLIT2 expression central nervous system, little is known about acute promyelocytic leukemia. Hence, we aimed to investigate levels of leukemia (APL) and assess its biological activity vitro vivo. Our analysis indicated that blasts SLIT2high transcript were associated cycle arrest, while SLIT2low APL...
Summary Progression to aggressive secondary acute myeloid leukaemia (sAML) poses a significant challenge in the management of myeloproliferative neoplasms (MPNs). Since physiopathology MPN is closely linked activation interferon (IFN) signalling and that AML initiation aggressiveness driven by stem cells (LSCs), we investigated these pathways sAML progression. We found high IFN correlated with low LSC samples, while progression transformation were characterized decreased increased signature....
Abstract Although the mixed lineage leukemia 5 ( MLL5 ) gene has prognostic implications in acute promyelocyte (APL), underlying mechanism remains to be elucidated. Here, we demonstrate critical role exerted by APL regarding cell proliferation and resistance drug-induced apoptosis, through mtROS regulation. Additionally, overexpression increased responsiveness of leukemic cells all-trans retinoic acid (ATRA)-induced differentiation, via regulation epigenetic modifiers SETD7 LSD1 . In silico...
To identify the frequency of polymorphism in IL-10 gene, rs1800896 (-1082 A/G), women with preeclampsia (PE) and a control group to associate presence this protection against development PE.This was case-control study conducted on 54 PE, classified according criteria National High Blood Pressure Education Program, 172 at least two healthy pregnancies. The proposed studied by technique real time polymerase chain reaction (qPCR), hydrolysis probes. Statistical analysis performed using χ2 test....
Introduction: Human papillomavirus (HPV), belonging to the Papovavirida family, is most prevalent sexually transmitted disease (STD) agent worldwide. In Brazil, it estimated that there are 3-6 million people infected with HPV. Aim: The aim of this study was evaluate knowledge young male students about penis cancer related HPV infection. Methods: This exploratory and quantitative conducted analyze answers 242 attending a private college located in Uberaba city, Minas Gerais state, during...
Abstract While it is increasingly becoming clear that cancers are a symbiosis of diverse cell types and tumor clones, the microenvironment (TME) in acute myeloid leukemias (AML) remains poorly understood. Here, we uncover functional prognostic relevance an M2-polarized macrophage compartment. Intra bone marrow co-injection M2d-macrophages together with leukemic blasts fail to engraft on their own now induce fatal leukemia mice. Even short-term two-day vitro exposure M2d macrophages can...
PURPOSE: To investigate the frequencies of polymorphic allele and genotypes for LT-α gene, position +252 (rs909253), in Brazilian women with preeclampsia. METHODS: This is a case-control study, which 30 preeclampsia, classified according to criteria National High Blood Pressure Education Program, 115 control group, at least two healthy pregnancies, were selected. Peripheral blood was collected, DNA extracted, followed by genotyping, using specific primers restriction analysis. The obtained...
Several lines of research suggest that Bcl-xL-mediated anti-apoptotic effects may contribute to the pathogenesis myeloproliferative neoplasms driven by JAK2V617F and serve as therapeutic target. Here, we used a knock-in mouse model confirmed Bcl-xL was overexpressed in erythroid progenitors. The neoplasm (MPN)-induced phenotype peripheral blood conditional abrogated knockout Bcl2l1, which presented anemia thrombocytopenia independently JAK2 mutation status. Mx1-Cre Jak2V617W/VF /Bcl2l1f/f...
In cancer, tumor cells and their neoplastic microenvironment can sculpt the immunogenic phenotype of a developing tumor. this context, natural killer (NK) are subtypes lymphocytes innate immune system recognized for potential to eliminate cells, not only through direct cytolytic activity but also by favoring development an adaptive antitumor response. Even though protective effect against leukemia due NK-cell alloreactivity mediated absence KIR-ligand has already been shown, some data on...
Background: Mutations in TP53 (TP53mut) are present approximately 10% of acute myeloid leukemia (AML) patients and represent a unique subtype with very poor prognosis. Although the exact mechanisms TP53mut driven leukemogenesis remain elusive, transcriptional changes associated suppression signaling pathway considered to confer dismal prognosis on patients. Aims: Using molecular profiling large cohort AML (n=654) we identify new prognostic subgroup that is TP53-wt but shares strong...
Background: Overexpression of the Meningioma-1 (MN1) gene drives leukemia development in mice and is also a poor prognostic marker human acute myeloid (AML). Expression MN1 blocks differentiation promotes AML through several mechanisms, usually involving BAF complex stabilization strong dependency on MEIS1/AbdB-like HOX protein complex. We demonstrated genetic homogeneous subtype that lentiviral overexpression (OE) primary APL cells (n=5 patient samples) allowed vivo engraftment using...
Topic: 3. Acute myeloid leukemia - Biology & Translational Research Background: Despite recent progress in the treatment of AML, overall survival for elderly patients remains dismal. Concerns regarding fit individuals to tolerate intensive chemotherapy schemes have motivated development non-intensive therapies. The Slit Guidance Ligand 2 (SLIT2) gene encodes a glycoprotein which has been shown play key roles different physiological processes. In leukemia, its high expression was associated...