A5037035880- COVID-19 Clinical Research Studies
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Long-Term Effects of COVID-19
- Dermatological and COVID-19 studies
- Multiple Sclerosis Research Studies
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Immunotherapy and Immune Responses
- Malaria Research and Control
- Pediatric health and respiratory diseases
- Immune cells in cancer
- Autism Spectrum Disorder Research
- Mindfulness and Compassion Interventions
- Immune Cell Function and Interaction
- Toxin Mechanisms and Immunotoxins
- Reproductive Biology and Fertility
- Veterinary Oncology Research
- Maternal and Neonatal Healthcare
- COVID-19 epidemiological studies
- Seed Germination and Physiology
- Pharmacology and Obesity Treatment
- Pharmacological Effects of Natural Compounds
- Optimism, Hope, and Well-being
- Biochemical and Molecular Research
Universidade Federal do Triângulo Mineiro
2019-2025
The saliva of hematophagous arthropods, such as ticks and triatomines, contains bioactive ligands capable modulating immune molecules, including cytokines. Cytokines play a critical role in regulation have therapeutic relevance inflammatory immune-mediated diseases. Despite recent advances, identifying cytokine-binding molecules remains significant challenge. Interferon-gamma (IFN-γ), interleukin-4 (IL-4), interleukin-17 (IL-17) are key cytokines involved inflammation, adaptive immunity,...
COVID-19, also known as coronavirus disease 2019, is an infectious viral caused by SARS-CoV-2, a novel coronavirus. Since its emergence, epidemiology has been explored; however, for some regions of the world, COVID-19’s behavior, incidence, and impact remain unclear. In continental nations like Brazil, this lack knowledge results in nonuniform control, prevention, treatment measures, which can be controversial locations. This study aimed to describe epidemiological profile patients with...
Multiple sclerosis is mediated by self-reactive myelin T and B cells that lead to axonal damage. The immune response in multiple involves the participation of CD4+ produce cytokines chemokines. This important find markers for diagnosis progression disease. In our work, we evaluated profile chemokines, as well production double positive IFNγ IL-17 patients with sclerosis, at different stages disease undergoing treatments. We found relapsing-remitting had a significant increase IL-12...
Eclampsia is a hypertensive disorder that occurs during pregnancy and can lead to death. The literature has gaps by not providing comprehensive data on the epidemiology of disease, restricting analysis limited temporal intervals geographical locations. This study aims characterize epidemiological profile women who died from eclampsia in Brazil 2000 2021.
Chagas disease is a neglected tropical caused by the parasite Trypanosoma cruzi. Despite efforts and distinct methodologies, search of antigens for diagnosis, vaccine, drug targets still needed. The present study aimed at identifying possible that could be used drugs against T. cruzi using reverse vaccinology molecular docking. genomes 28 strains available in GenBank (NCBI) were to obtain genomic core. Then, subtractive genomics was carried out identify nonhomologous genes host A total 2630...
Introduction: By July 2023, Brazil had administered approximately 540 million COVID-19 vaccine doses. This study aimed to quantify wasted doses resulting from dead space in supplies. Methods: The supply was initially weighed, filled with distilled water, and expelled simulate administration. Weighing it again after the application determined volume. Descriptive analyses calculated waste rate/wasted dose count. Results: estimated total number of using supplies lowest 62,097,338. Conclusions:...
Dendritic cells (DCs) are a type of antigen-presenting that play an important role in the immune response against Trypanosoma cruzi, causative agent Chagas disease. In vitro and vivo studies have shown modulation these by this parasite can directly affect innate acquired host order to facilitate its biological cycle spreading species. Many show mechanisms which T. cruzi modulates DCs, but interaction with Mexican strains such as Ninoa INC5 has not yet been properly investigated. Here, we...
Multiple sclerosis is an autoimmune disease that affects the central nervous system. In Brazil, there are currently several therapeutic options for treatment of this condition, with some being distributed free charge, while others not included in list medications. The objective article to provide a pharmacoepidemiological analysis available medications country, covering their mechanisms action, historical context approval and distribution within healthcare system, geographical application....
Between 2017 and 2021, the Brazilian Unified Health System (BUHS) administered a total of 527,903,302 doses immunizations. Each immunization results in presence residual volume (RV) due to syringe dead space (DS). The International Organization for Standardization 7886-1 allows DS up 0.07mL sterile single-use hypodermic syringes with volumes less than 5mL. This study aims quantify devices used Brazil, best combinations needles minimize RV, estimate number wasted from evaluate impact on BUHS....
Abstract Congenital transmission of Chagas disease plays an important role in endemic countries because it is not a diagnosis that encountered frequently prenatal care. Due to limited information regarding congenital Trypanosoma cruzi Mexico, the present study aimed investigate protozoan infectivity and modulation immune responses human placental explants infected with T. Ia Mexican strains. The Inc-5 strain showed increased modulated IL-1 β , IL-10 TLR-4, decreasing their expression after...
Noni, also known as Morinda citrifolia, is a plant that has been widely used for treating various pathologies due to its allegedly anti-inflammatory and immunomodulating properties. Macrophages monocytes are critical immune cells initiate inflammation generate an response against aggressors, regardless of their causative agent. However, it not well investigated how noni fruit components affect the behavior or phenotype these cells. Hence, studies in this direction could potentially...
Background/Objectives: Cytokine storm in severe COVID-19 is responsible for irreversible tissue damage and death. Soluble mediators from the TNF superfamily, their correlation with clinical outcome, use of receptors as a potent predictor outcome were evaluated. Methods: Severe patients had levels soluble superfamily quantified categorized according to (death versus survival). Statistical modeling was performed predict outcomes. Results: have elevated serum superfamily. Regardless sex age,...
This work aims to evaluate the effects of rapid thermoresistance on morphofunctional aspects membranes using flow cytometry, as well quality sperm chromatin Toluidine Blue technique, both before and after test.Six sets frozen semen from ten bulls were used. The samples thawed in a water bath at 36ºC separated into two aliquots. first aliquot, control group (C), was kept test tube previously heated with subsequent evaluations microscopy, analyses. second experimental (E), underwent (RTT)...
This randomized controlled trial evaluated the stress, anxiety, and burnout of professionals exposed to complementary spiritist therapy (CST), which consists in therapeutic resources as prayer, Spiritist passe, fluidic water spiritual education or control.Seventy-six were CST control: maintain routine for 5 weeks. The ISSL scale, anxiety depression Beck's indices, Maslach instrument, subjective well-being WHOQOL-BREF used at baseline five-week. Blood count cytokine dosage collected baseline,...
Beside the acute respiratory syndrome caused by COVID-19, exacerbated inflammatory process leads to systemic coagulation disorders, cardiovascular renal failure, metabolic changes and other clinical manifestations, increasing mortality of patients with severe forms disease. The development effective vaccines drugs for adequate treatment disease has become a priority scientific medical community. Likewise, discovery possible predictors early identification cases high risk death are constantly...