A5083638556- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- Hedgehog Signaling Pathway Studies
- interferon and immune responses
- Renal and related cancers
- Smoking Behavior and Cessation
- FOXO transcription factor regulation
- Cancer Cells and Metastasis
- Neurotransmitter Receptor Influence on Behavior
- Nicotinic Acetylcholine Receptors Study
- Cell Adhesion Molecules Research
- Genetics and Neurodevelopmental Disorders
- Spinal Cord Injury Research
- Mesenchymal stem cell research
- Lung Cancer Research Studies
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- Pharmacological Effects of Natural Compounds
- MicroRNA in disease regulation
- Galectins and Cancer Biology
- Neurobiology and Insect Physiology Research
- Chromatin Remodeling and Cancer
- Neuroblastoma Research and Treatments
- Acute Lymphoblastic Leukemia research
Universidade Estadual de Londrina
2012-2021
Universidade Federal de São Paulo
2006-2019
Centro de Investigaciones Biológicas Margarita Salas
2014
Entomological Society of Brazil
2014
Therapy with mesenchymal stem cells (MSCs) has showed to be promising due its immunomodulatory function. Traumatic brain injury (TBI) triggers immune response and release of inflammatory mediators, mainly cytokines, by glial creating a hostile microenvironment for endogenous neural (NSCs). We investigated the effects factors secreted MSCs on NSC in vitro analyzed cytokines expression TBI model. Our results show that MSC-secreted increase proliferation induce higher GFAP, indicating tendency...
Neural stem/progenitor cells (NSC) respond to injury after brain injuries secreting IL-1, IL-6, TNF-α, IL-4 and IL-10, as well chemokine members of the CC CXC ligand families. CXCL12 is one chemokines secreted at an site known attract NSC-derived neuroblasts, that express receptor, CXCR4. Activation CXCR4 by depends on two domains located N-terminal chemokine. In present work we aimed investigate if end CXCL12, where binding activation are located, was sufficient induce neuroblast...
Triple negative breast cancer (TNBC) is a relevant subgroup of neoplasia which presents phenotype estrogen and progesterone receptors has no overexpression the human epidermal growth factor 2 (HER2). FOXP3 (forkhead transcription 3) marker regulatory T cells (Tregs), whose expression may be increased in tumor cells. This study aimed to investigate polymorphism (rs3761548) protein for possible involvement TNBC susceptibility prognosis. Genetic was evaluated 50 patients 115 controls by...
CXCR4 genetic polymorphisms, as well their expression level, have been associated with cancer development and prognosis. The present study aimed to investigate the influence of rs2228014 polymorphism on its mRNA protein in breast samples. It was observed that patients presented higher relative (5.7-fold) than normal mammary gland, but this not correlated clinicopathological features (nuclear grade, nodal status, ER PR p53 staining, Ki67 index, HER-2 status). Moreover, also did differ...
Metastasis is a key factor that limits survival in the majority of patients with cancer. Thus, numerous efforts have been made to elucidate molecular mechanisms involved this phenomenon. B16‑F10 melanoma cells demonstrated be highly metastatic lungs mice. The aim current study was investigate role CXC motif chemokine receptor 4 (CXCR4) potential In vitro transfection tumor CXCR4 short hairpin RNA (shRNA) expressing plasmids (CXCR4 shRNA) significantly reduced expression levels mRNA (80%) and...
The aim of this study was to determine if variable number tandem repeats (VNTR) in the second intron (STin2) serotonin transporter (SLC6A4) gene associated with tobacco use disorder, successful smoking cessation, or characteristics. In case–control study, patients current diagnosed according DSM IV criteria (n = 185), and never-smokers, CDC 175), were recruited received 52 weeks combined pharmacotherapy cognitive therapy. Successful cessation defined as exhaled carbon monoxide < 6 ppm....
Wilms’ tumor is an embryonal neoplasm of the kidney that accounts for approximately 6 % all childhood tumors. The chemokine CXCL12 (C-X-C ligand 12) and its CXCR4 receptor type 4) are involved in development several organs, including kidney, also associated with growth metastasis. FOXP3 (forkhead transcription factor 3) was initially described as a marker regulatory T cells; however, expression types cells has already been may have prognostic significance. aim present study to analyze...
When compared to other model organisms whose genome is sequenced, the number of mutations identified in mouse appears extremely reduced and this situation seriously hampers our understanding mammalian gene function(s). Another important consequence shortage that a majority human genetic diseases still await an animal model. To improve situation, two strategies are currently used: first makes use embryonic stem cells, which one can induce knockout almost at will; second consists genome-wide...
Background The HER 2 (human epidermal growth factor receptor‐2) Ile655Val (rs1136201) genetic polymorphism can alter the receptor structure and its auto‐activation, which modify signal transduction and, consequently, cell cycle regulation. For this reason, has been extensively investigated as a candidate marker for breast cancer ( BC ). In context, aim of study was to evaluate possible influence in susceptibility prognostic factors Brazilian population. Methods Polymorphism genotype assessed...
Inulin is an effective prebiotic and its potential in modulating systemic immunity have been proposed. A subpopulation of T cells, named regulatory cells (Tregs), expressing the Forkhead boxP3 transcription factor are key mediators peripheral tolerance suppress undesirable immune responses. These Tregs can be induced by cytokine transforming growth beta (TGF-β) interleukin 10 (IL-10). This work aimed to evaluate inulin effects on human blood mononuclear (PBMC) vitro. PBMC were incubated with...
The aim of the present study was to investigate rs1800468 (G-800A), rs1800469 (C-509T), rs1800470 (C29T), and rs1800471 (G74C) TGFB1 genetic polymorphisms their haplotype structures in patients with Wilms Tumor (WT) neoplasia-free controls. genomic DNA extracted from 35 WT 160 children, were genotyped by polymerase chain reaction, followed restriction fragment length polymorphism. inferred, permutation logistic regression tests performed check for differences distribution between control...
O meduloblastoma é um tumor cerebelar caracterizado como neuroectodérmico primitivo prevalente em crianças, sendo as do sexo masculinos mais afetadas. Com relação à classificação histológica, existem cinco variações: clássico, desmoplásico, anaplásico, células gigantes e de extensa nodularidade. Muitos estudos relatam que a patogênese está relacionada com mutações fatores crescimento SNC, principais vias envolvidas são: Sonic Hedgehog, NOTCH, WNT OTX. Ainda, respeito imunologia, pacientes...
A subgroup of tumor that has received attention is triple-negative breast cancer (TNBC), which presents phenotype negative estrogen receptor, progesterone receptor and no overexpression HER2. TP53 acts as a suppressor limiting the proliferation damaged cells. polymorphic site (rs1042522) encodes either an arginine or proline amino acid, but its biological significance remains unclear. This study aimed to investigate this variant expression in search for possible involvement TNBC...
O meduloblastoma é um tumor cerebelar caracterizado como neuroectodérmico primitivo prevalente em crianças, sendo as do sexo masculinos mais afetadas. Com relação à classificação histológica, existem cinco variações: clássico, desmoplásico, anaplásico, células gigantes e de extensa nodularidade. Muitos estudos relatam que a patogênese está relacionada com mutações fatores crescimento SNC, principais vias envolvidas são: Sonic Hedgehog, NOTCH, WNT OTX. Ainda, respeito imunologia, pacientes...