A5030777834- Multiple Sclerosis Research Studies
- Systemic Lupus Erythematosus Research
- Toxoplasma gondii Research Studies
- HIV Research and Treatment
- Acute Ischemic Stroke Management
- T-cell and Retrovirus Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- HIV/AIDS Research and Interventions
- Cytokine Signaling Pathways and Interactions
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- HIV/AIDS drug development and treatment
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Tryptophan and brain disorders
- Parasitic Infections and Diagnostics
- Science and Education Research
- Adipokines, Inflammation, and Metabolic Diseases
- Hepatitis B Virus Studies
- Stress Responses and Cortisol
- Systemic Sclerosis and Related Diseases
- Hepatitis C virus research
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammatory Bowel Disease
- Asthma and respiratory diseases
Universidade Estadual de Londrina
2015-2024
Pontifícia Universidade Católica do Paraná
2023-2024
Deakin University
2021
Weatherford College
2021
Public Health Dayton & Montgomery County
2011
Hospital Universitário Regional do Norte do Paraná
1998-2011
Hospital de Clínicas
2010
The persistent activation of the hypothalamic-pituitary-adrenal axis and sympathetic-adrenal-medullary axes in chronic stress response depression impairs immune contributes to development progression some types cancer. This overview presents results from experimental animal models, human studies, clinical evidence that various cellular molecular immunological parameters are compromised depression. At level, stressed depressed patients had overall leukocytosis, high concentrations circulating...
Multiple sclerosis (MS) is a progressive immune‑ mediated disease caused by demyelination of the central nervous system. Cytokines and their receptors have an important role in evolution MS lesions, pro‑ anti‑inflammatory cytokine levels been found to correlate with changes activity. The aims present study were evaluate pro‑inflammatory [tumor necrosis factor (TNF)‑α interleukin (IL) ‑1β, ‑6 ‑12], T helper (Th) 1 [interferon (IFN)‑γ], Th17 (IL‑17) Th2 (IL‑4 ‑10) serum relapsing‑remitting...
The aims of this study were to delineate cytokine profiles systemic lupus erythematosus (SLE), construct prediction models for diagnosis and disease activity using those profiles, examine the associations between TNFB Ncol polymorphism, body mass index (BMI) vitamin D levels with levels. Two hundred SLE patients 196 healthy controls participated in case–control study. Plasma cytokines tumor necrosis factor (TNF)‐α, interferon (IFN)‐γ, interleukin (IL)‐1β, IL‐ 4, IL‐6, IL‐10, IL‐12 IL‐17...
An association between depression and altered immune hormonal systems has been suggested by the results of many studies. In present study we carried out measurements in 40 non-medicated, ambulatory adult patients with determined CID-10 criteria compared 34 healthy nondepressed subjects. The severity condition was Hamilton Depression Rating Scale. Of depressed patients, 31 had very severe 9 or moderate depression, 29 (72.5%) were females 11 (27.5%) males (2.6:1 ratio). revealed a significant...
Oxidative stress exerts an important role on the pathophysiological mechanisms of systemic lupus erythematosus (SLE). This study investigated oxidative in patients with SLE and its correlation disease activity, corticosteroid therapy, liver function biomarkers. The included 58 105 healthy volunteers. Patients showed increase evaluated by tert-butyl hydroperoxide-initiated chemiluminescence (CL-LOOH), advanced oxidation protein products (AOPP), nitric oxide metabolites. C-reactive (CRP) was...
The aim of this study was to evaluate associations between seropositivity for IgG and IgM anti-Toxoplasma gondii antibodies socio-economic environmental variables in pregnant women Londrina, state Paraná, Brazil. We interviewed 492 women, each whom answered an epidemiological questionnaire, collected blood samples measurement anti-T. by chemiluminescence. A confirmatory diagnosis acute infection made avidity test. Titres specific were obtained IFAT. Seropositivity observed 242 (49.2%) and,...