A5039434599- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Atherosclerosis and Cardiovascular Diseases
- Cytokine Signaling Pathways and Interactions
- Dental Research and COVID-19
- Cell Adhesion Molecules Research
- SARS-CoV-2 detection and testing
- Oral microbiology and periodontitis research
- Retinal and Optic Conditions
- Monoclonal and Polyclonal Antibodies Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Cell Function and Interaction
- Urticaria and Related Conditions
- COVID-19 diagnosis using AI
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and disorders
- Platelet Disorders and Treatments
- COVID-19 Clinical Research Studies
Instituto Federal de Educação Ciência e Tecnologia do Paraná
2024
Instituto Federal de Educação, Ciência e Tecnologia do Pará
2024
Universidade Estadual de Londrina
2017-2023
The aims of this study were to delineate cytokine profiles systemic lupus erythematosus (SLE), construct prediction models for diagnosis and disease activity using those profiles, examine the associations between TNFB Ncol polymorphism, body mass index (BMI) vitamin D levels with levels. Two hundred SLE patients 196 healthy controls participated in case–control study. Plasma cytokines tumor necrosis factor (TNF)‐α, interferon (IFN)‐γ, interleukin (IL)‐1β, IL‐ 4, IL‐6, IL‐10, IL‐12 IL‐17...
Background This study was performed to assess adhesion molecules in systemic lupus erythematosus (SLE). Methods case-control examined 126 SLE patients and 48 healthy individuals. Blood levels of six molecules, cortisol, nuclear autoantibody (ANA) anti-double stranded DNA (anti-dsDNA) titers were measured, while disease activity assessed using the Disease Activity Index (SLEDAI) score. Results Platelet endothelial cell molecule 1 (PECAM-1), vascular (VCAM-1), E-selectin, P-selectin,...
The aims of the present study were to evaluate biomarkers oxidative and nitrosative stress in systemic lupus erythematosus (SLE) patients, particular products DNA/RNA damage their correlation with disease activity. This included 188 controls 203 patients; 153 inactive SLE (SLEDAI < 6) 50 active ≥ without renal impairment. Oxidative was assessed by tert-butyl hydroperoxide—initiated chemiluminescence, advanced oxidation protein (AOPP), total radical-trapping antioxidant parameter (TRAP),...
Abstract The aim of this study was to evaluate the association rs2232365 (-924 G > A) and rs3761548 (-3279 C FOXP3 variants with systemic lupus erythematosus (SLE) susceptibility, TGF-β1 plasma levels, autoantibodies, LN nephritis, SLE disease activity index (SLEDAI). included 196 female patients 157 controls. were determined polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP). Plasma levels using immunofluorimetric assay. AA genotype [OR: 2.650, CI...
The aim of this study was to evaluate the association +869 T > C (rs1800470) and −509 (rs1800469) TGFB1 variants, individually or in haplotypes structure, with susceptibility, autoantibodies, disease activity, TGF-β1 plasma levels patients systemic lupus erythematosus (SLE). included 203 SLE 165 healthy controls. variants were determined by real-time polymerase chain reaction (qPCR). Plasma using immunofluorimetric assay. + 869 CC genotype associated susceptibility (OR: 1.710, 95%CI:...
Abstract Background: The aim of this study was to evaluate the effects toothbrushing with a dentifrice containing antimicrobial phthalocyanine derivative (APD) for intraoral reduction viral load SARS-CoV-2.Material and methods: Twenty COVID-19 positive dentate patients were selected toothbrushes APD 2 minutes. Self-collected samples unstimulated saliva carried out three times: T0 (baseline, before toothbrushing), T5 (5 minutes after T30 (30 toothbrushing). analysis RNA performed by RT-PCR...
The aim of this study was to assess whether toothbrushing with a dentifrice containing an antimicrobial phthalocyanine derivative (APD) can reduce the intraoral viral load SARS-CoV-2. Twenty COVID-19-positive dentate patients aged ≥18 years were selected instructed brush their teeth for 2 min APD. Self-collected samples unstimulated saliva carried out three times: T0 (baseline), T5 (5 after toothbrushing), and T30 (30 toothbrushing). analysis RNA performed by RT-qPCR detection genes (ORF1ab,...
In individuals with coronavirus disease (COVID-19), the severe acute respiratory syndrome 2 (SARS-CoV-2) viral load (VL) plays an important role in infectivity.This study aimed to evaluate reduction VL and infectivity induced by phthalocyanine mouthwash nasal spray patients COVID-19.Patients mild COVID-19 were recruited participate a triple-blinded randomized controlled trial. Participants assigned one of three groups: Group 1, non-active saline (SNS); 2, SNS; 3 spray. was assessed...
<h3>Background and aims</h3> To delineate cytokines profiles of systemic lupus erythematosus (SLE), construct prediction models for diagnosis disease activity using those profiles, examine how TNFB Ncol polymorphism, body mass index (BMI), vitamin D, cortisol influence cytokine levels in SLE. <h3>Methods</h3> 200 SLE patients 196 healthy controls participated this case-control study. Plasma TNF-α, IFN-γ, IL-1β, IL-4, IL-6, IL-10, IL-12, IL-17 were measured computed. <h3>Results</h3> IL-17,...
<h3>Background and aims</h3> To delineate disorders in adhesion molecules systemic lupus erythematosus (SLE) to assess whether cortisol, nuclear autoantibody (ANA) titers the metabolic syndrome (MetS) are associated with SLE. <h3>Methods</h3> 48 healthy individuals 171 SLE patients were enrolled. Disease activity was determined by SLEDAI (SLE Activity Index) score. Adhesion cortisol levels evaluated. <h3>Results</h3> Platelet endothelial cell molecule 1 (PECAM-1), Vascular (VCAM-1),...
Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease, characterized by dysregulated innate and adaptive immune responses.The regulatory CD4+CD25+ T (Treg) cells plays a crucial role in suppression of the response.The FoxP3 belongs to forkhead/winged-helix family transcription factors it considered master regulator Treg development function.Different single nucleotide variants (SNVs) have been described promoter region FOXP3, which can affect expression FOXP3 impair...