A5058998372- T-cell and Retrovirus Studies
- Multiple Sclerosis Research Studies
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Adipokines, Inflammation, and Metabolic Diseases
- Systemic Lupus Erythematosus Research
- HIV Research and Treatment
- Hepatitis B Virus Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Toxoplasma gondii Research Studies
- Iron Metabolism and Disorders
- Acute Ischemic Stroke Management
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Parasitic Infections and Diagnostics
- Hepatitis Viruses Studies and Epidemiology
- T-cell and B-cell Immunology
- Erythropoietin and Anemia Treatment
- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- Immunotherapy and Immune Responses
- Inflammasome and immune disorders
- Hepatitis C virus research
Universidade Estadual de Londrina
2011-2021
Hospital de Clínicas
2010-2011
Hospital Universitário Regional do Norte do Paraná
2011
The persistent activation of the hypothalamic-pituitary-adrenal axis and sympathetic-adrenal-medullary axes in chronic stress response depression impairs immune contributes to development progression some types cancer. This overview presents results from experimental animal models, human studies, clinical evidence that various cellular molecular immunological parameters are compromised depression. At level, stressed depressed patients had overall leukocytosis, high concentrations circulating...
Multiple sclerosis (MS) is a progressive immune‑ mediated disease caused by demyelination of the central nervous system. Cytokines and their receptors have an important role in evolution MS lesions, pro‑ anti‑inflammatory cytokine levels been found to correlate with changes activity. The aims present study were evaluate pro‑inflammatory [tumor necrosis factor (TNF)‑α interleukin (IL) ‑1β, ‑6 ‑12], T helper (Th) 1 [interferon (IFN)‑γ], Th17 (IL‑17) Th2 (IL‑4 ‑10) serum relapsing‑remitting...
Eur J Clin Invest 2010; 40 (4): 330–338 Abstract Background The magnitude of lipoprotein level reduction during the acute‐phase response may be associated with severity and mortality sepsis. However, it remains to determined whether low levels can considered a risk factor for developing We aimed investigate as factors sepsis in hospitalized patients, also describe sequential changes cholesterol ester transfer protein (CETP) Design This is prospective cohort study case–control analysis from...
The metabolic syndrome (MetS) comprises pathological conditions that include insulin resistance, arterial hypertension, visceral adiposity and dyslipidaemia, which favour the development of CVD. Some reports have shown cranberry ingestion reduces cardiovascular risk factors. However, few studies evaluated effect this fruit in subjects with MetS. objective present study was to assess reduced-energy juice consumption on inflammatory biomarkers patients MetS, verify effects concomitantly...
An association between depression and altered immune hormonal systems has been suggested by the results of many studies. In present study we carried out measurements in 40 non-medicated, ambulatory adult patients with determined CID-10 criteria compared 34 healthy nondepressed subjects. The severity condition was Hamilton Depression Rating Scale. Of depressed patients, 31 had very severe 9 or moderate depression, 29 (72.5%) were females 11 (27.5%) males (2.6:1 ratio). revealed a significant...
The aim of the present study was to verify effects fish oil and a soya-based product on inflammatory markers endothelial function measured by NO in women with metabolic syndrome (MetS). A total sixty-five (mean age: 47·9 ( sd 9·98) years) were studied 90-d parallel, randomised design. control group maintained their usual diet; second received 29 g/d soyabean (kinako); third 3 n -3 fatty acids; fourth (3 g/d) kinako (29 g/d). Anthropometric, blood pressure (BP), markers, anti-inflammatory...
Com o objetivo de determinar a soroprevalência tripanossomíase americana, sífilis, toxoplasmose, rubéola, hepatite B, C e infecção pelo vírus da imunodeficiência humana em gestantes atendidas no Hospital Universitário Regional Norte do Paraná, Universidade Estadual Londrina, foi realizado estudo retrospectivo dos resultados testes sorológicos efetuados período junho 1996 1998. As taxas positividade encontradas foram: 0,9% para 1,6% 67% (IgG) 1,8% (IgM) 89% 1,2% 0,8% B (AgHBs), 0,6% humana....
The municipality of Londrina ranks second in the number AIDS cases state Paraná, Brazil, with Ministry Health notified 1070 from 1984 to 2002. aim this study was determine seroprevalence and risk factors for HTLV-1/2 infection HIV-infected patients attending Reference Center serving (and surrounding region), Brazil. Data concerning sociodemographic conditions were collected 784 patients, using a questionnaire. Blood samples obtained 758 subjected serologic screening tests determination...
A cross-sectional study was carried out among 996 volunteer blood donors enrolled from May 1999 to December determine the seroprevalence of hepatitis E virus (HEV) infection Regional Blood Bank Londrina, State Paraná, Brazil, and evaluate whether rate IgG anti-HEV antibodies is associated with sociodemographic variables seropositivity for (HAV) infection. All participants answered questionnaire regarding characterisitcs. Serum samples were tested HEV (anti-HEV) by an enzyme linked...
Cardiovascular disease (CVD) has emerged as an important cause of death in patients with systemic lupus erythematosus (SLE). Reduced adiponectin and elevated leptin levels may contribute to CVD SLE patients. The purpose this study was verify the effects fish oil (FO) on SLE. Biochemical activity analysis were performed. Patients divided two groups: who used for four months did not use oil. FO had a significant decrease index (SLEDAI) score (p ˂ 0.023) relation baseline. increased 0.026)...
Background: Parkinson's disease (PD) is a neurodegenerative disorder characterized by complex interplay between peripheral and central inflammatory oxidative stress pathways. Keywords: Inflammation, iron metabolism, stress, disease, Peripheral biomarkers, Systemic disease.
The current diagnosis of human T-lymphotropic virus type-2 (HTLV-2) infection is based on the search specific antibodies; nevertheless, several studies conducted in Brazil pointed deficiencies commercially available kits detecting HTLV-2, mostly HIV/AIDS patients. This study searched for presence HTLV-1 and -2 758 patients from Londrina, Paraná, Brazil. Serum samples were screened HTLV-1/2 antibodies using two EIA (Vironostika Murex), confirmed by WB (HTLV Blot 2.4, Genelabs). results...