A5042829268- Multiple Sclerosis Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Systemic Lupus Erythematosus Research
- COVID-19 Clinical Research Studies
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Fatty Acid Research and Health
- Acute Ischemic Stroke Management
- Cytokine Signaling Pathways and Interactions
- Diet, Metabolism, and Disease
- Dental Research and COVID-19
- Folate and B Vitamins Research
- Asthma and respiratory diseases
- Vitamin D Research Studies
- Systemic Sclerosis and Related Diseases
- Gut microbiota and health
- SARS-CoV-2 detection and testing
- T-cell and B-cell Immunology
- Diet and metabolism studies
- Antioxidant Activity and Oxidative Stress
- Phytoestrogen effects and research
- Liver Disease Diagnosis and Treatment
- Oral microbiology and periodontitis research
- SARS-CoV-2 and COVID-19 Research
Universidade Estadual de Londrina
2016-2025
Pontifícia Universidade Católica do Paraná
2024
Instituto Federal de Educação Ciência e Tecnologia do Paraná
2024
Instituto Federal de Educação, Ciência e Tecnologia do Pará
2024
Deakin University
2021
Weatherford College
2021
Multiple sclerosis (MS) is a progressive immune‑ mediated disease caused by demyelination of the central nervous system. Cytokines and their receptors have an important role in evolution MS lesions, pro‑ anti‑inflammatory cytokine levels been found to correlate with changes activity. The aims present study were evaluate pro‑inflammatory [tumor necrosis factor (TNF)‑α interleukin (IL) ‑1β, ‑6 ‑12], T helper (Th) 1 [interferon (IFN)‑γ], Th17 (IL‑17) Th2 (IL‑4 ‑10) serum relapsing‑remitting...
The aims of this study were to delineate cytokine profiles systemic lupus erythematosus (SLE), construct prediction models for diagnosis and disease activity using those profiles, examine the associations between TNFB Ncol polymorphism, body mass index (BMI) vitamin D levels with levels. Two hundred SLE patients 196 healthy controls participated in case–control study. Plasma cytokines tumor necrosis factor (TNF)‐α, interferon (IFN)‐γ, interleukin (IL)‐1β, IL‐ 4, IL‐6, IL‐10, IL‐12 IL‐17...
American cutaneous leishmaniasis is a zoonotic disease caused by protozoans of the genus Leishmania. The treatment unsatisfactory, thus, much research effort has been focused on investigating new compounds with lower collateral effects to patients and derived from low-cost sources, such as natural products. In present study, we evaluated in vitro directly effect flavonoid quercetin against Leishmania (Viannia) braziliensis. Quercetin inhibited proliferation promastigote forms at all tested...
Abstract Reactive oxygen species oxidize proteins and modulate the proteasomal system in muscle‐wasting cancer cachexia. On day 5 (D5), 10 (D10), 14 (D14) after tumor implantation, skeletal muscle was evaluated. Carbonylated thiobarbituric acid reactive substances were measured. Chemiluminescence employed for lipid hydroperoxide estimation. Glutathione, superoxide dismutase, total radical antioxidant capacity The assessed by mRNA atrogin‐1 expression. Increased wasting, hydroperoxide,...
The metabolic syndrome (MetS) comprises pathological conditions that include insulin resistance, arterial hypertension, visceral adiposity and dyslipidaemia, which favour the development of CVD. Some reports have shown cranberry ingestion reduces cardiovascular risk factors. However, few studies evaluated effect this fruit in subjects with MetS. objective present study was to assess reduced-energy juice consumption on inflammatory biomarkers patients MetS, verify effects concomitantly...
The risk of contamination and dissemination by SARS-CoV-2 has a strong link with nasal, oral pharyngeal cavities. Recently, our research group observed the promising performance an anionic phthalocyanine derivative (APD) used in mouthwash protocol without photoexcitation; this improved general clinical condition patients infected SARS-CoV-2. present two-arm study evaluated vitro antiviral activity cytotoxicity APD. Additionally, triple-blind randomized controlled trial was conducted 41...