A5084550827- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Toxoplasma gondii Research Studies
- Insect and Pesticide Research
- Antifungal resistance and susceptibility
- Bee Products Chemical Analysis
- Insect Pest Control Strategies
- Fungal Infections and Studies
- Herpesvirus Infections and Treatments
- Synthesis and biological activity
- HIV Research and Treatment
- Parasitic Infections and Diagnostics
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Antimicrobial Peptides and Activities
- Cytomegalovirus and herpesvirus research
- Chemical synthesis and pharmacological studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Paraoxonase enzyme and polymorphisms
- Parasite Biology and Host Interactions
- Healthcare Regulation
- Heme Oxygenase-1 and Carbon Monoxide
- Phytochemistry and biological activities of Ficus species
- interferon and immune responses
Universidade Estadual de Londrina
2015-2024
Fundação Carlos Chagas
2022
American cutaneous leishmaniasis is a zoonotic disease caused by protozoans of the genus Leishmania. The treatment unsatisfactory, thus, much research effort has been focused on investigating new compounds with lower collateral effects to patients and derived from low-cost sources, such as natural products. In present study, we evaluated in vitro directly effect flavonoid quercetin against Leishmania (Viannia) braziliensis. Quercetin inhibited proliferation promastigote forms at all tested...
Social and epidemiological aspects of dengue were evaluated in an important metropolitan area southern Brazil, from August 2012 to September 2014. Demographic, clinical, serological data collected patients with acute symptoms treated at public health system units (HSUs). A systematic approach analyze the spatial temporal distribution cases was developed, considering cross-correlation between weather, correlation income over city's census tracts. From 878 suggestive symptoms, 249 diagnosed as...
The fact that drugs currently used in the treatment of Leishmania are highly toxic and associated with acquired resistance has promoted search for new therapies treating American tegumentary leishmaniasis (ATL). In this study, BALB/c mice were injected hind paw (Leishmania) amazonensis subsequently treated a combination nitric oxide (NO) donor (cis-[Ru(bpy) 2imN(NO)](PF6)3) (Ru-NO), given by intraperitoneal injection, oral Brazilian propolis 30 days. Ru-NO reached center lesion increased NO...
Dengue virus (DV) infection can cause either a self-limiting flu-like disease or threatening hemorrhage that may evolve to shock and death. A variety of cell types, such as dendritic cells, monocytes, B be infected by DV. However, despite the role T lymphocytes in control DV replication, there remains paucity information on possible DV-T interactions during course. In present study, we have demonstrated primary human naive CD4+ CD8+ cells are permissive for infection. Importantly, both...
The antileishmanial and immunomodulatory effects of propolis collected in Botucatu, São Paulo State, Brazil, were evaluated Leishmania (Viannia) braziliensis experimental infection. effect on promastigote forms was verified by reducing growth promoting morphologic alterations observed scanning electron microscopy. In vitro assays, macrophages pretreated with then infected L. (V.) . vivo , supernatants from liver cells peritoneal exudate BALB/c mice (10 7 /mL promastigotes) collected,...
Caryocar coriaceum fruits, found in Brazilian Cerrado and Caatinga, are commonly used as food folk medicine, anti‐inflammatory, bactericide, fungicide, leishmanicide, nematicide. Due to the biological potential of this plant, study focuses on evaluation antifungal antileishmanial activities, including anticholinesterase antioxidant tests, correlating with total phenols flavonoids content. Peel extracts contain higher yield analyzed by spectrophotometric methods. HPLC analysis revealed that...
Leishmania amazonensis ( L. ) infection can cause severe local and diffuse injuries in humans, a condition clinically known as American cutaneous leishmaniasis (ACL). Currently, the therapeutic approach for ACL is based on Glucantime, which shows high toxicity poor effectiveness. Therefore, remains neglected disease with limited options treatment. Herein, vitro antiprotozoal effect mechanisms of diterpene kaurenoic acid [ ent -kaur-16-en-19-oic acid] (KA) against were investigated. KA...
The conventional treatment for toxoplasmosis with pyrimethamine and sulfadiazine shows toxic effects to the host, it is therefore necessary search new drugs. Some studies suggest use of statins, which inhibit cholesterol synthesis in humans also initial processes isoprenoid biosynthesis parasite. Thus, objective this study was evaluate activity statins pravastatin simvastatin HeLa cells infected vitro RH strain T. gondii. (1 × 105) were gondii tachyzoites (5 following two different...
The immunoregulatory effect of Artin M and jacalin from extract Artocarpus integrifolia seeds (jack extract) against infection with Candida albicans was investigated. Swiss mice received jack containing 500 μg protein/ml PBS intraperitoneally (i.p.) or alone after 72 h were infected i.p. C. CR15 (10(7)) sacrificed 30 min, 2, 6, 24, h. ELISA analysis revealed that in extract-treated IFN-γ predominantly produced versus IL-10 control mice. These results suggest induced a protective immune...
Nitric oxide (NO) is a free radical synthesized from L-arginine by different isoforms NO-synthases. NO possesses multiple and complex biological functions. an important mediator of homeostasis, changes in its generation or actions can contribute not to pathological states. The knowledge effects has been only our understanding immune response, but also new tools for research treatment various diseases. Knowing the importance as inflammatory diverse infectious diseases, we decided develop...