A5076651858- Carcinogens and Genotoxicity Assessment
- Fungal Biology and Applications
- Genomics, phytochemicals, and oxidative stress
- Environmental Toxicology and Ecotoxicology
- Plant tissue culture and regeneration
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Plant Toxicity and Pharmacological Properties
- Herbal Medicine Research Studies
- Phytochemistry and Bioactivity Studies
- Plant Genetic and Mutation Studies
- Phytochemistry Medicinal Plant Applications
- Phytoestrogen effects and research
- Bioactive Compounds and Antitumor Agents
- Nutrition, Genetics, and Disease
- Cancer therapeutics and mechanisms
- Selenium in Biological Systems
- Effects and risks of endocrine disrupting chemicals
- Polysaccharides and Plant Cell Walls
- Reproductive Biology and Fertility
- Cell death mechanisms and regulation
- Microbial Metabolites in Food Biotechnology
- Vitamin D Research Studies
- Cancer-related Molecular Pathways
- Natural product bioactivities and synthesis
Universidade Estadual de Londrina
2016-2025
SOS Mata Atlântica Foundation
2021
Centro Universitário Filadélfia
2013
Universidade Estadual Paulista (Unesp)
1991-2013
Sociedade Brasileira de Biologia Celular
2013
Universidade Federal de Mato Grosso do Sul
2013
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2002-2012
Unidad Ejecutora Lillo
2008
Universidade Estadual de Campinas (UNICAMP)
2000-2006
Hospital de Clínicas da Unicamp
2000-2005
Cytotoxicity of metals is important because some are potential mutagens able to induce tumors in humans and experimental animals. Chromium can damage DNA several ways, including double strand breaks (DSBs) which generate chromosomal aberrations, micronucleus formation, sister chromatid exchange, formation adducts alterations replication transcription. In our study, water samples from three sites the Córrego dos Bagres stream Franca municipality Brazilian state São Paulo were subjected comet...
Genotoxicity studies on toxic metals and their organic compounds are very important, especially so in the investigation of effects these aquatic environments where they tend to accumulate. The use endemic organisms as biological sentinels has proved useful environmental monitoring. We assessed mutagenic potential tributyltin (TBT) inorganic lead (PbII) using samples fish Hoplias malabaricus (commonly called traíra) comet assay piscine micronucleus chromosome aberration tests. Eighteen H....
The use of medicinal plants by the general population is an old and still widespread practice, which makes studies their genotoxicity essential. Psidium guajava L. Achillea millefolium are examples commonly used in popular medicine. P. indicated for diarrhea also as antiseptic, while A. analgesic, antispasmodic, digestive, diuretic, astringent, emollient, wound healer hemorrhoid medication. aim this study was to determine effects infusions these two plant species on chromosomes cell cycle....
Agaricus brasiliensis (previously named blazei ss. Heinem), also known as the sun mushroom is native of Southeast Brazil, and widely consumed, mainly in form tea, due to its nutritional pharmacological properties. In this study, we tested aqueous (AqE) ethanol (EtOHE) extracts an isolated polysaccharide (PLS) from fruiting body A. brasiliensis, for antiviral activity against poliovirus type 1 HEp-2 cells.The evaluation time addition by plaque assay showed that when AqE, PLS EtOHE were added,...
The treatment of textile effluents by the conventional method based on activated sludge followed a chlorination step is not usually an effective to remove azo dyes, and can generate products more mutagenic than untreated dyes. present work evaluated efficiency genotoxicity/mutagenicity dyes Disperse Red 1, Orange 13 from aqueous solutions. comet micronucleus assays with HepG2 cells Salmonella mutagenicity assay were used. degradation dye molecules after same was also evaluated, using...
The effects of clastogenic or mutagenic agents have rarely been studied in neotropical fish species exposed to contaminated water. In this study, the genetic damage caused by lead widely distributed South American fish, Hoplias malabaricus, was assessed using comet (SCGE) assay and testing for chromosomal aberrations. Eighteen specimens were acclimatized laboratory conditions then chronically food feeding prey (Cyprinus sp.) injected intraperitoneally with doses inorganic adjusted give a...
The development of various types cancer results from the interaction among endogenous, environmental and hormonal factors, where most notable these factors is diet. aim present study was to determine antigenotoxic, anticarcinogenic, phagocytic immunomodulatory activities Agaricus blazei. test antigenotoxicity (Comet Assay) anticarcinogenic (Test Aberrant Crypt Foci) assess changes in DNA and/or intestinal mucosa that correlate development. Tests phagocytosis spleen differential count blood...
Phenols are a large and diverse class of compounds, many which occur naturally in variety food plants; they exhibit wide range biological effects, including antibacterial, antiinflammatory, antiallergic, hepatoprotective, antithrombotic, antiviral, anticarcinogenic, vasodilatory actions.We examined the genotoxic clastogenic potential three phenolic compounds: caffeic, cinnamic ferulic acids, using comet micronucleus assays vitro.Drug-metabolizing rat hepatoma tissue cells (HTCs) were...
Alzheimer's disease (AD) is the most common form of dementia and has no cure. Therapeutic strategies focusing on reduction oxidative stress, modulation amyloid-beta (Aβ) toxicity inhibition tau protein hyperphosphorylation are warranted to avoid development progression AD. The aim this study was screen crude extracts (CEs) ethyl-acetate fractions (EAFs) Guazuma ulmifolia, Limonium brasiliense, Paullinia cupana, Poincianella pluviosa, Stryphnodendron adstringens Trichilia catigua using...
Piperlongumine (PLN) is a biologically active alkaloid/amide derived from Piper longum, with known promising anticancer activity. The aim of this study was to compare the antiproliferative activity PLN in human breast MCF-7 adenocarcinoma cell line effects HB4a normal mammary epithelial non-tumor line. parameters examined were growth, viability, reactive oxygen species (ROS) levels and DNA damage, as well on modulating targets responsible through regulation these pathways. increased ROS...
Abstract Rubus imperialis Chum. Schl. (Rosaceae) have demonstrated some pharmacological activities, including gastroprotective action. However, genotoxic effects of R. extract was also reported. Since niga‐ichigoside F1 (NIF1) is a major compound this plant species, and which has proven properties, it essential to investigate whether responsible for the observed toxicity. Therefore, objective study analyze NIF1 on HepG2/C3A cells possible cytogenotoxicity, cell cycle apoptosis influence,...
Rubus imperialis Chum. Schl. (Rosaceae) is used in traditional medicine as a remedy to treat diabetes and other diseases. However, there are reports that the extract of this plant others genus may produce cellular and/or genetic toxicity. Niga-ichigoside F1 (NIF1) 2β,3β-19α-trihydroxyursolic acid (2B) major compounds found R. known exert pharmacological effects which be responsible for observed Thus, study was aimed examine cytogenotoxic potential NIF1 2B human peripheral blood mononuclear...