A5073569615- Cancer therapeutics and mechanisms
- Phytoestrogen effects and research
- Cell death mechanisms and regulation
- Bioactive Compounds and Antitumor Agents
- Glutathione Transferases and Polymorphisms
- Curcumin's Biomedical Applications
- Phytochemical Studies and Bioactivities
- Silk-based biomaterials and applications
- Synthesis of Indole Derivatives
- Heme Oxygenase-1 and Carbon Monoxide
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Computational Drug Discovery Methods
- Cancer Research and Treatments
- Potato Plant Research
- Silkworms and Sericulture Research
- Molecular Biology Techniques and Applications
- Genomics, phytochemicals, and oxidative stress
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- Phytochemistry and biological activity of medicinal plants
- Pharmacogenetics and Drug Metabolism
- Piperaceae Chemical and Biological Studies
- Selenium in Biological Systems
- Plant Genetic and Mutation Studies
Universidade Estadual de Londrina
2012-2024
Piperlongumine (PLN) is a biologically active alkaloid/amide derived from Piper longum, with known promising anticancer activity. The aim of this study was to compare the antiproliferative activity PLN in human breast MCF-7 adenocarcinoma cell line effects HB4a normal mammary epithelial non-tumor line. parameters examined were growth, viability, reactive oxygen species (ROS) levels and DNA damage, as well on modulating targets responsible through regulation these pathways. increased ROS...
Background: Genistein (5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is the most abundant isoflavone in soybean, which has been associated with a lower risk of development cancer and cardiovascular diseases. Of particular interest regarding preventive properties flavonoids their interaction cytochrome P450 enzymes (CYPs). However, contradictory data report effect genistein on expression СYPs enzymes. Objective: The aim this study was to investigate effects (CYP) gene levels human...
Curcumin is an antiproliferative phytochemical extracted from Curcuma longa L and which has been studied in preclinical drug screening using cell monolayers animal models. However, several limitations of these culture systems may be overcome by performing with three-dimensional (3-D) culture. The aim this study was to investigate the effects curcumin on cytotoxicity genotoxicity as well spheroid growth cervical adenocarcinoma HeLa spheroids RT-PCR mRNA expression genes involved death (CASP3,...
Fluopsin C is an antibiotic compound derived from secondary metabolism of different microorganisms, which possesses antitumor, antibacterial, and antifungal activity. Related to fluopsin antiproliferative activity, the aim this study was examine following parameters: cytotoxicity, genotoxicity, cell cycle arrest, death induction (apoptosis), mitochondrial membrane potential (MMP), colony formation, mRNA expression genes involved in adaptive stress responses cellular utilizing a monolayer. In...
The α-tomatine is a steroidal glycoalkaloid found in immature tomatoes (Lycopersicon esculentum) that has important biological functions including the inhibition of cancer cell growth and preventing metastasis. This study aimed to evaluate effects on cytotoxicity, cellular proliferation, apoptosis, mRNA expression APC, CCNA2, β-catenin, CASP9, BAK, BAX BCL-XL colorectal adenocarcinoma line HT-29. HT29 cells were treated with three concentrations (0.1, 1 10 µg/mL), although only µg/mL...
The identification of antitumoral substances is the focus intense biomedical research. Two structural analogues thalidomide, LNO3 and L3, are two synthetic compounds that might possess such antitumor properties. We evaluated toxicological effects these substances, including cytotoxicity, genotoxicity induction apoptosis in HTC cells. Additionally, production free radicals (nitric oxide superoxide) was investigated, expression caspases genes 3, 8, 9 were determined by RT-qPCR. exhibited...
β-Glucans (βG) are polysaccharides widely distributed in nature with chemopreventive properties. The aim of this study was to investigate the effects βG and combined treatment doxorubicin (Dox) on cell viability mRNA levels genes involved cycle, apoptosis antioxidant response. not cytotoxic. CCNA2 cells exposed β-glucan upregulated exposure Dox decreased expression, while combination led an upregulation. Modulation CASP9 suggest that could inhibit promotion progression steps carcinogenesis,...