A5078329992- Research on Leishmaniasis Studies
- Insect Pest Control Strategies
- Trypanosoma species research and implications
- Insect and Pesticide Research
- Phytochemistry and Biological Activities
- Parasites and Host Interactions
- Phytochemical compounds biological activities
- Phytochemistry and biological activities of Ficus species
- Paraoxonase enzyme and polymorphisms
- Macrophage Migration Inhibitory Factor
- Chemical synthesis and pharmacological studies
- Rabies epidemiology and control
- Toxoplasma gondii Research Studies
- Natural product bioactivities and synthesis
- Phytochemistry and Bioactivity Studies
- Phytochemistry Medicinal Plant Applications
- SARS-CoV-2 and COVID-19 Research
- Sesquiterpenes and Asteraceae Studies
- Traditional and Medicinal Uses of Annonaceae
- Synthesis and Biological Evaluation
- Bioactive natural compounds
- Plant-derived Lignans Synthesis and Bioactivity
- Synthesis of heterocyclic compounds
- Quinazolinone synthesis and applications
- Long-Term Effects of COVID-19
Universidade Estadual de Londrina
2017-2024
The Leishmaniasis treatment currently available involves some difficulties, such as high toxicity, variable efficacy, cost, therefore, it is crucial to search for new therapeutic alternatives. Over the past few years, research on drugs has focused use of natural compounds chalcones and nanotechnology. In this context, aimed at assessing in vitro leishmanicidal activity free 4-nitrochalcone (4NC) promastigotes encapsulated 4NC L. amazonensis-infected macrophages, well their action mechanisms....
American tegumentary leishmaniasis, a zoonotic disease caused by the Leishmania genus, poses significant challenges in treatment, including administration difficulty, low efficacy, and parasite resistance. Novel compounds or associations offer alternative therapies, natural products such as oregano essential oil (OEO), extracted from Origanum vulgare, have been extensively researched due to biological effects, antibacterial, antifungal, antiparasitic properties. Silver nanoparticles (AgNp),...
The use of compounds from natural or synthetic sources and nanotechnology may represent an alternative to develop new drugs for the leishmaniasis treatment. DETC is inhibitor SOD1 enzyme, which leads increased ROS production, important elimination Leishmania. Thus, our objective was assess leishmanicidal in vitro effect free Diethydithiocarbamate (DETC) loaded beeswax-copaiba oil nanoparticles (DETC-Beeswax-CO Nps) on L. amazonensis forms elucidate possible mechanisms involved parasite...
Lung cancer is one of the leading causes cancer-related deaths in men and women worldwide. Current treatments have limited efficacy, cause significant side effects, cells can develop drug resistance. New therapeutic strategies are needed to discover alternative anticancer agents with high efficacy low-toxicity. TMBP, a biphenyl obtained by laccase-biotransformation 2,6-dimethoxyphenol, possesses antitumor activity against A549 adenocarcinoma cells. Without causing damage sheep erythrocytes...
Background: Conventional therapies for breast cancer are still a challenge due to cytotoxic drugs not being highly effective with significant adverse effects. Thiohydantoins biologically active heterocyclic compounds reported several biological activities, including anticarcinogenic properties, etc. This work aims assess the use of thiohydantoin as potential antitumor agent against MCF-7 cells. Methods: MTT and neutral red assays were used possible activity Cell volume measurement analysis...
Leishmaniasis is a neglected tropical disease that affects millions of people around the world. Larval excretion/secretion (ES) larvae flies Calliphoridae family has microbicidal activity against Gram-positive and Gram-negative bacteria, in addition to some species Leishmania. Our study aimed at assessing vitro efficacy Lucilia cuprina larval ES promastigote amastigote forms Leishmania amazonensis, elucidating possible mechanisms routes death involved. was able inhibit viability L....