A5045202106- interferon and immune responses
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Research on Leishmaniasis Studies
- Cytokine Signaling Pathways and Interactions
- Biochemical and Molecular Research
- Trypanosoma species research and implications
- Galectins and Cancer Biology
- Parasites and Host Interactions
- Tuberculosis Research and Epidemiology
- HIV Research and Treatment
- Biochemical Acid Research Studies
- Education during COVID-19 pandemic
- Amoebic Infections and Treatments
- Herpesvirus Infections and Treatments
- Immunotherapy and Immune Responses
- Education and Digital Technologies
- Plant Virus Research Studies
- Cytomegalovirus and herpesvirus research
- Autoimmune Bullous Skin Diseases
- Metabolism and Genetic Disorders
- Science and Education Research
- Atherosclerosis and Cardiovascular Diseases
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
Universidade Federal de Santa Catarina
2016-2024
Instituto Federal de Educação Ciência e Tecnologia do Norte de Minas Gerais
2021
Fundação Oswaldo Cruz
2008-2016
University of Cambridge
2015
The establishment of a virus infection is the result pathogen's ability to replicate in hostile environment generated by host's immune system. Here, we found that ISG15 restricts Dengue and Zika viruses' replication through stabilization its binding partner USP18. expression was necessary control DV driven both autocrine paracrine type one interferon (IFN-I) signaling. Moreover, USP18 competes with NS5-mediated STAT2 degradation, major mechanism for flavivirus infection. Strikingly,...
Dengue virus (DV) infection can cause either a self-limiting flu-like disease or threatening hemorrhage that may evolve to shock and death. A variety of cell types, such as dendritic cells, monocytes, B be infected by DV. However, despite the role T lymphocytes in control DV replication, there remains paucity information on possible DV-T interactions during course. In present study, we have demonstrated primary human naive CD4+ CD8+ cells are permissive for infection. Importantly, both...
Abstract IFN-stimulated gene 15 (ISG15) deficiency in humans leads to severe IFNopathies and mycobacterial disease, the latter being previously attributed its extracellular cytokine-like activity. In this study, we demonstrate a novel role for secreted ISG15 as an IL-10 inducer, unique primary human monocytes. A balanced ISG15-induced monocyte/IL-10 versus lymphoid/IFN-γ expression, correlating with p38 MAPK PI3K signaling, was found using targeted vitro ex vivo systems analysis of...
Abstract Targeting regions of proteins that show a high degree structural conservation has been proposed as method developing immunotherapies and vaccines may bypass the wide genetic variability RNA viruses. Despite several attempts, vaccine protects evenly against four circulating Dengue virus (DV) serotypes remains elusive. To find critical conserved amino acids in dengue viruses, 120 complete genomes each serotype were selected at random used to calculate scores for nucleotide acid...
Herpes simplex virus 1 (HSV-1) has extensive interactions with the host DNA damage response (DDR) machinery that can be either detrimental or beneficial to virus. Proteins in homologous recombination pathway are known required for efficient replication of viral genome, while different members classical non-homologous end-joining (c-NHEJ) have opposing effects on HSV-1 infection. Here, we investigated role recently-discovered c-NHEJ component, PAXX (Paralogue XRCC4 and XLF), which found...
Em 2020, o advento de uma nova realidade veio reforçar a ligação entre educação e as tecnologias, em virtude da ocorrência pandemia COVID-19. Sendo assim, presente trabalho teve como objetivo identificar potencialidades fragilidades proposta ensino Biologia nas modalidades distância extraclasse, ofertadas no período pandemia. Para tanto, foi realizada pesquisa qualiquantitativa tendo público alvo os estudantes do Ensino Médio participantes referido projeto. Os resultados indicaram...
Abstract Background Hexose transporters (HT) are membrane proteins involved in the uptake of energy-supplying glucose and other hexoses into cell. Previous studies employing Differential Display technique have shown that transcription level HT gene from T. cruzi ( TcrHT ) is higher an vitro- induced benznidazole (BZ)-resistant population parasite (17 LER) than its susceptible counterpart WTS). Methods In present study, has been characterized populations strains resistant or to BZ. We...
SUMMARY The establishment of a virus infection is the result pathogen’s ability to replicate in hostile environment generated by host’s immune system. Here, we found that ISG15 restricts Dengue and Zika viruses’ replication through stabilisation its binding partner USP18. expression was necessary control DV driven both autocrine paracrine type one interferon (IFN-I) signalling. Moreover, USP18 competes with NS5-mediated STAT2 degradation, major mechanism for flavivirus infection. Strikingly,...
Interferon stimulated gene 15 (ISG15) deficiency in humans leads to severe interferonopathies and mycobacterial disease, the latter being previously associated its extracellular cytokine-like activity. Here, we demonstrate a novel role for secreted ISG15 as an IL-10 inducer, unique human primary monocytes. Employing ex vivo systems analysis of transcriptome datasets, observed significant correlation ISG15-induced monocyte lymphocyte IFNγ balanced expression. This effect was with p38 MAPK...
Abstract Interferon stimulated gene 15 (ISG15) deficiency in humans leads to severe interferonopathies and mycobacterial disease, the latter being previously attributed its extracellular cytokine-like activity. Here, we demonstrate a novel role for secreted ISG15 as an IL-10 inducer, unique primary human monocytes. Employing ex vivo systems analysis of transcriptome datasets, observed significant correlation ISG15-induced monocyte lymphocyte IFNγ expression. This effect was associated with...