A5059379149- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Renal function and acid-base balance
- Nitric Oxide and Endothelin Effects
- High Altitude and Hypoxia
- Climate Change and Health Impacts
- Insect symbiosis and bacterial influences
- Viral Infections and Outbreaks Research
- Eicosanoids and Hypertension Pharmacology
- Traumatic Brain Injury and Neurovascular Disturbances
Fundação Carlos Chagas
2019-2023
Universidade do Oeste de Santa Catarina
2014
The Zika virus (ZIKV) is an arthropod-borne that belongs to the Flaviviridae family. ZIKV infection usually asymptomatic or associated with mild clinical manifestations; however, increased numbers of cases microcephaly and birth defects have been recently reported. To date, neither a vaccine nor antiviral treatment has become available control replication. Among natural compounds recognized for their medical properties, flavonoids, which can be found in fruits vegetables, possess biological...
Social and epidemiological aspects of dengue were evaluated in an important metropolitan area southern Brazil, from August 2012 to September 2014. Demographic, clinical, serological data collected patients with acute symptoms treated at public health system units (HSUs). A systematic approach analyze the spatial temporal distribution cases was developed, considering cross-correlation between weather, correlation income over city's census tracts. From 878 suggestive symptoms, 249 diagnosed as...
Vascular dysfunction plays a central role in sepsis, and it is characterized by hypotension hyporesponsiveness to vasoconstrictors. Nitric oxide regarded as element of sepsis vascular dysfunction. The high amounts nitric produced during are mainly derived from the inducible isoform synthase 2. We have previously shown that 2 levels decrease later stages whereas activity soluble guanylate cyclase increase. Therefore, we studied putative other relevant sources, namely, neuronal (nitric 1)...
The pathogenesis of Dengue virus (DENV) infection is complex and involves viral replication that may trigger an inflammatory response leading to severe disease. Here, we investigated the correlation between viremia cytokine levels in serum DENV-infected patients. Between 2013 2014, 138 patients with a diagnosis acute-phase DENV 22 non-dengue acute febrile illness (AFI) were enrolled. Through focus-forming assay (FFU), determined observed peak first two days after onset symptoms. A higher...