A5040424175- Cervical Cancer and HPV Research
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- TGF-β signaling in diseases
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- T-cell and Retrovirus Studies
- Hepatitis B Virus Studies
- Cancer-related molecular mechanisms research
- Animal Virus Infections Studies
- Science and Education Research
- Prostate Cancer Treatment and Research
- T-cell and B-cell Immunology
- Genetic factors in colorectal cancer
- HIV Research and Treatment
- NF-κB Signaling Pathways
- Plant Virus Research Studies
- Kruppel-like factors research
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Chronic Lymphocytic Leukemia Research
- Cancer Cells and Metastasis
- Immunodeficiency and Autoimmune Disorders
Universidade Estadual de Londrina
2016-2025
Fundação Araucária
2021
Centro de Ensino Superior de Juiz de Fora
2013
Pathological Society
2006
Unidad Ejecutora Lillo
2005
High-risk Human Papillomavirus (HPV) infection is the main etiological factor for cervical carcinogenesis, although genetic cofactors also play a role. Single-nucleotide variants (SNVs) in CTLA4 gene can alter expression and immune response against HPV, influencing malignancy progression. This study analyzed association of alleles, genotypes, haplotypes SNVs rs5742909 (−318 C>T), rs231775 (+49 A>G), rs3087243 (+6230 G>A) with HPV infection, development low-grade squamous...
Chemokines and their receptors regulate the trafficking of immune cells during development, inflammation, tissue repair. The single-nucleotide polymorphism (SNP) rs1801157 (previously known as CXCL12-A/ stromal cell-derived factor-1 (SDF1)-3'A) in CXCL12/SDF1 gene was assessed breast cancer, Hodgkin's lymphoma (HL), non-Hodgkin's (NHL), since chemokine CXCL12, previously SDF1, its receptor CXCR4 leukocyte many essential biological processes, including tumor growth, angiogenesis, metastasis...
It is generally well-accepted and established the IL-10-mediated protumor function in cancer, based on its immunosuppressive properties. However, new evidences from <em>in vitro</em> vivo</em> murine models have emerged showing a potential immunostimulating activity of this cytokine, which may sustain antitumor hence favoring tumor regression. Here, we attempt to clarify IL-10's role by conducting literature review previously published studies, presenting information about IL-10 and/or...
The aim of this study was to determine the incidence infections and cytological abnormalities investigate possible predisposing factors such as sociodemographic characteristics, sexual behavioral habits, gynecological obstetric backgrounds. Between 2013 December 2016, a cross-sectional conducted among 429 consenting women, from whom cervical samples were tested for presence Human papillomavirus (HPV) by polymerase chain reaction (PCR). Susceptibility HPV infection assessed binary logistic...
Torque teno virus (TTV) is a non-enveloped human DNA isolated by Nishizawa et al. in 1997. 1 TTV, recently classified as the Alphatorquevirus genus within Anelloviridae family International Committee on Taxonomy of Viruses (ICTV), was first with single-stranded circular genome to be identified. 2Thus far, five main genetic groups (Groups 1-5) involving at least 39 genotypes have been identified based phylogenetic analysis. 3he TTV can divided into an untranslated region (UTR) 1.2 kb and...
Chronic myelogenous leukemia (CML) is a malignant myeloproliferative disorder that originates from pluripotent stem cell expressing the bcr-abl oncogene. It characterized by an abnormal release of expanded, clone bone marrow into circulation. The stromal derived factor-1 (SDF-1) gene contains common polymorphism, termed SDF1-3'A, in evolutionarily conserved segment 3' untranslated region (UTR). In this work SDF-1 genotypes 25 patients (9-82 years old) who had been clinically and...
Triple negative breast cancer (TNBC) is a relevant subgroup of neoplasia which presents phenotype estrogen and progesterone receptors has no overexpression the human epidermal growth factor 2 (HER2). FOXP3 (forkhead transcription 3) marker regulatory T cells (Tregs), whose expression may be increased in tumor cells. This study aimed to investigate polymorphism (rs3761548) protein for possible involvement TNBC susceptibility prognosis. Genetic was evaluated 50 patients 115 controls by...
CXCR4 genetic polymorphisms, as well their expression level, have been associated with cancer development and prognosis. The present study aimed to investigate the influence of rs2228014 polymorphism on its mRNA protein in breast samples. It was observed that patients presented higher relative (5.7-fold) than normal mammary gland, but this not correlated clinicopathological features (nuclear grade, nodal status, ER PR p53 staining, Ki67 index, HER-2 status). Moreover, also did differ...