A5042873566- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Immune Response and Inflammation
- Cervical Cancer and HPV Research
- Immunotherapy and Immune Responses
- TGF-β signaling in diseases
- Immune Cell Function and Interaction
- Nanoparticle-Based Drug Delivery
- Reproductive Physiology in Livestock
- Kruppel-like factors research
- Pneumocystis jirovecii pneumonia detection and treatment
- Antifungal resistance and susceptibility
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Mitochondrial Function and Pathology
- Fungal Infections and Studies
- Bone health and treatments
- T-cell and B-cell Immunology
- Bone health and osteoporosis research
- Bone Tissue Engineering Materials
Universidade Federal do Paraná
2019-2024
Universidade Estadual de Londrina
2017-2018
We investigated the molecular mechanisms underlying azole resistance in seven Candida tropicalis isolates that caused candidemia and candiduria Paraná, Brazil (2016–2022). Biofilm production, antifungal susceptibility testing, multilocus sequence typing, amplification sequencing of ERG11, quantification MDR1, CDR1 expression levels were performed. Notably, five (71.4%) from urine samples two (28.6%) blood samples. All strains biofilm producers, with ranging moderate to strong. The minimum...
It is generally well-accepted and established the IL-10-mediated protumor function in cancer, based on its immunosuppressive properties. However, new evidences from <em>in vitro</em> vivo</em> murine models have emerged showing a potential immunostimulating activity of this cytokine, which may sustain antitumor hence favoring tumor regression. Here, we attempt to clarify IL-10's role by conducting literature review previously published studies, presenting information about IL-10 and/or...
Regulatory T cell (Treg) lineage plays a central role in inflammation and autoimmunity control. Interleukin-10 (IL-10) has been described as pleiotropic cytokine that is mainly released by CD4+ CD25+ FOXP3+ Treg cells potent immunosuppressive activity. Forkhead box P3 (FOXP3) transcription factor expression crucial for to function suppressor cell, FOXP3 gene single nucleotide variants (SNVs) have already shown influence on viral pathogenesis. This study was conducted evaluate the plasmatic...
MicroRNAs (miRNAs) regulate gene expression by binding to complementary sequences within target mRNAs. Apart from working ‘solo’, miRNAs may interact in important molecular networks such as competing endogenous RNA (ceRNA) axes. By for a limited pool of miRNAs, transcripts long noncoding RNAs (lncRNAs) and mRNAs can each other, fine-tuning expression. Several ceRNA led different lncRNAs—described here lncRNA-mediated ceRNAs—seem play essential roles cervical cancer (CC). conducting an...