A5028497942- Peptidase Inhibition and Analysis
- Salivary Gland Disorders and Functions
- Head and Neck Cancer Studies
- Ferroptosis and cancer prognosis
- Advanced Proteomics Techniques and Applications
- Antifungal resistance and susceptibility
- Chemotherapy-induced cardiotoxicity and mitigation
- Healthcare Regulation
- Oral health in cancer treatment
- Macrophage Migration Inhibitory Factor
- Machine Learning in Bioinformatics
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer-related gene regulation
- Fungal Infections and Studies
- Nitric Oxide and Endothelin Effects
- RNA and protein synthesis mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Oral Health Pathology and Treatment
- GDF15 and Related Biomarkers
- Erythropoietin and Anemia Treatment
- Public Health in Brazil
- Inflammatory Biomarkers in Disease Prognosis
- Calcium signaling and nucleotide metabolism
- Immune cells in cancer
- Thyroid Cancer Diagnosis and Treatment
Brazilian Center for Research in Energy and Materials
2017-2024
Brazilian Biosciences National Laboratory
2017-2024
Laboratório Nacional de Ciência e Tecnologia do Bioetanol
2018-2024
Weatherford College
2021
Pontifícia Universidade Católica de Campinas
2021
Universidade Estadual de Campinas (UNICAMP)
2017
Universidade Estadual de Londrina
2010-2011
Abstract Different regions of oral squamous cell carcinoma (OSCC) have particular histopathological and molecular characteristics limiting the standard tumor−node−metastasis prognosis classification. Therefore, defining biological signatures that allow assessing prognostic outcomes for OSCC patients would be great clinical significance. Using histopathology-guided discovery proteomics, we analyze neoplastic islands stroma from invasive tumor front (ITF) inner to identify differentially...
Protease activity has been associated with pathological processes that can lead to cancer development and progression. However, understanding the unbalance in proteolysis is challenging because changes occur simultaneously at protease, their inhibitor, substrate levels. Here, we present a pipeline combines peptidomics, proteomics, peptidase predictions for studying proteolytic events saliva of 79 patients association oral squamous cell carcinoma (OSCC) prognosis. Our findings revealed...
The poor prognosis of head and neck cancer (HNC) is associated with metastasis within the lymph nodes (LNs). Herein, proteome 140 multisite samples from a 59-HNC patient cohort, including primary matched LN-negative or -positive tissues, saliva, blood cells, reveals insights into biology potential biomarkers that may assist in clinical decision-making. Protein profiles are strictly immune modulation across datasets, this provides basis for investigating markers metastasis. LN metastatic...
Candida albicans pode causar graves infecções em pacientes que estão imunocomprometidos por doenças, cirurgias ou terapia imunossupressiva. Os altos níveis de morbidade e mortalidade resultantes hospitalizados mostraram C. tornou-se um patógeno humano grande relevância clínica. Mesmo o sistema imune sendo principal fator define a transição do fungo comensal para patogênico, fatores virulência expressados albicans, tais como adesinas, mudança fenotípica, comportamento dimórfico, secreção...
SUMMARY The poor prognosis of head and neck cancer (HNC) is associated with the presence metastasis within lymph nodes (LNs). Herein, proteome 140 multisite samples from a 59-HNC patient cohort, including primary matched LN-negative or -positive tissues, saliva, blood cells, reveals insights into biology potential biomarkers that may assist in clinical decision making. Protein profiles are strictly immune modulation across datasets, this provides basis for investigating markers metastasis....
Abstract Background. The most common oral cancer in the world is squamous cell carcinoma (OSCC), accounting for more than 90% of all cases cavity. Thus, research on molecular markers associated with development and progress human diseases has been subject intense research. findings that saliva profiles indicating systemic urge study non-invasive diagnosis using as source potential diagnosis, prognosis predictive based proteomics. Methods. 204 proteotypic peptides were selected previously DDA...
Background. The most common oral cancer in the world is squamous cell carcinoma (OSCC), accounting for more than 90% of all cases cavity. Thus, research on molecular markers associated with development and progress human diseases has been subject intense research. findings that saliva profiles indicating systemic urge study non-invasive diagnosis using as source potential diagnosis, prognosis predictive based proteomics.Methods. 204 proteotypic peptides were selected previously DDA data from...