A5005758519- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Psoriasis: Treatment and Pathogenesis
- Asthma and respiratory diseases
- Synthesis and biological activity
- Inflammatory Bowel Disease
- Dermatology and Skin Diseases
- Helicobacter pylori-related gastroenterology studies
- Quinazolinone synthesis and applications
- Synthesis and Reactivity of Heterocycles
- Whipple's Disease and Interleukins
- Microscopic Colitis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cancer, Lipids, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Click Chemistry and Applications
- IL-33, ST2, and ILC Pathways
- Heme Oxygenase-1 and Carbon Monoxide
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Pharmacological Effects of Natural Compounds
- Prostate Cancer Treatment and Research
- Retinoids in leukemia and cellular processes
- Gut microbiota and health
- Vitamin D Research Studies
Universidade Estadual de Londrina
2019-2024
Fundação Oswaldo Cruz
2011-2016
Abstract Oxidative stress (OS) is associated with the onset of prostate cancer (PCa). The aims this study are to examine whether OS biomarkers may be employed as external validating criteria for diagnosis PCa. This case-control recruited 204 subjects, 73 patients PCa, 67 benign hyperplasia (BPH), and 64 healthy controls (HC) assayed plasma prostate-specific antigen (PSA), protein thiol (−SH) groups, lipid hydroperoxides, carbonyl proteins (PCB), advanced oxidation products (AOPP), total...
Abstract Eight crystal structures are reported here: substituted ( E ) benzaldehyde 7-chloro-1-methyl-4H-quinolinyl-4-ylidene-hydrazones, 1 , [substituted benzaldehyde: XYC 6 H 4 CHO: X,Y=H,H; 2-F,H; 3-F,H; 4-F,H; 3-Cl,H; 4-Cl,H; 2-Br,H and 2,3-Cl 2 ]. None of the molecules, overall planar: angles between phenyl quinolinyl rings vary from <5°, for :X,Y=3-F,H; 3-Cl,H to 15–16° : X,Y=H,H 4-Cl,H). The supramolecular arrangements in parent compound X=Y=H) generated solely C–Z···π (Z=H Cl)...
Abstract Three crystal structures are reported here: ( E,E )-arenecarbaldehyde 7-chloro-1-methyl-4H-quinolinyl-4-ylidene-hydrazones, 3 , [arenecarbaldehyde = 3-MeOC 6 H 4 CHO 3a ), 3,4-(MeO) 2 C 3b ) and 2,3-(MeO) 3c )]. While in each compound π···π stacking other intermolecular interactions make contributions to the overall supramolecular arrangements, very different arrangements result for relatively flat molecules of non-planar . In all possible [π(quin)···π(quin), π(quin)···π(phen)...
The aim of this study was to evaluate the association -924 G>A (rs2232365) and -3279 C>A (rs3761548) FOXP3 variants with IBD susceptibility, clinical endoscopic activity, IL-10 TGF-β1 plasma levels.The included 110 female patients, 60 Ulcerative Colitis (UC) 50 Crohn's Disease (CD), 154 controls. were determined Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Plasma levels using immunofluorimetric assay.AA genotype rs2232365 rs3761548 associated CD (OR = 3.147,...
Abstract A crystal structure determination confirmed that the product from 7-chloroquinilin-4-ylhydrazine and 4-methoxycinnanamic acid had been isolated MeOCH 2 CH OH solution as [( E )- N′- 7-chloro-4-(4-methoxycinnamolyhydrazinyl)quinoline, 1 . In contrast, recrystallization of 2-MeO derivative, , same solvent, produced a : co-crystalline mixture two tautomers, namely ( 7-chloro-4-(2-methoxycinnaämolyhydrazinyl)quinoline 7-chloro-4(1 H)quinolinone 3-(2-methoxycinnamoyl)hydrazone, molecules...
Abstract Ulcerative colitis (UC) is characterized by chronic inflammation of the large intestine. Disease activity and mucosal injury are affected Th17 cells their interleukin (IL)-17A. A link between genetic variations in IL17A genes autoimmunity susceptibility has been reported; however, results UC limited contradictory. The aim this study was to evaluate involvement receptor ( IL17RA) variants on susceptibility, IL-17A plasma levels, endoscopic UC. case-control included 104 patients 213...