A5105301766- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Crystal structures of chemical compounds
- Crystallography and molecular interactions
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Synthesis and Reactions of Organic Compounds
- Tuberculosis Research and Epidemiology
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Cancer therapeutics and mechanisms
- Phenothiazines and Benzothiazines Synthesis and Activities
- Research on Leishmaniasis Studies
- Synthesis and Reactivity of Heterocycles
- Quinazolinone synthesis and applications
- Chemical Synthesis and Analysis
- Multicomponent Synthesis of Heterocycles
- Trypanosoma species research and implications
- Bioactive Compounds and Antitumor Agents
- HIV/AIDS drug development and treatment
- Metal complexes synthesis and properties
- Antibiotics Pharmacokinetics and Efficacy
- Synthesis of Organic Compounds
- Analytical Chemistry and Chromatography
- Chemical Synthesis and Reactions
Fundação Oswaldo Cruz
2016-2025
Universidade Federal do Rio de Janeiro
2005-2023
Instituto de Tecnologia e Pesquisa
2003-2023
Universidade Federal do Oeste da Bahia
2023
Universidade de Brasília
1990-2021
University of Toronto
2019
Universidade Federal de Juiz de Fora
2002-2012
Instituto Nacional de Cardiologia
2011
Universidade Federal Fluminense
2011
Instituto Sapientia
2011
Several nicotinic and isoniazid derivatives, most of them containing nitro groups were synthesized by our group, evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H 37 Rv using the Alamar Blue susceptibility test expressed as minimum inhibitory concentration (MIC) mg/mL.The compound 11d exhibited best result (1.2 µg/mL) when compared with first line drugs such (INH) rifampicin (RIP).Therefore this class compounds could be a good starting point to develop...
The class of heterocyclic compounds known as thiazole is found in many natural and synthetic products with a wide range pharmacological activities, such antiviral, anticancer, antibacterial, antifungal, anticonvulsant, antiparkinsonian anti-inflammatory activities that can be well illustrated by the large number drugs market containing this function group. Due to its importance, aim review highlight synthesis biological activity reported between 2000 2004.
The carboxylic acid residue in the title compound, C6H4BrNO2, is twisted out of plane other atoms, as indicated by (Br)C—C—C—Ocarbonyl torsion angle −20.1 (9)°. In crystal, supramolecular chains mediated O—H⋯N hydrogen bonds are formed with base vector [201] and C—H⋯O interactions reinforce packing.
DRUGS ANTI-HIV: PAST, PRESENT AND FUTURE PERSPECTIVES.Currently available anti-HIV drugs can be classified into three categories: nucleoside analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside (NNRTIs) and protease (PIs).In addition to the (RT) reaction, various other events in HIV replicative cycle considered as potential targets for chemotherapeutic intervention: (1) viral adsorption, through binding envelope glycoprotein gp120; (2) entry, blockage of coreceptors CXCR4...
A new synthetic antimalarial drug, a salt derived from two molecules, mefloquine (MQ) and artesunate (AS), here named MEFAS, has been tested for its pharmacological activity. Combinations of AS plus MQ hydrochloride are currently being used in areas with drug-resistant Plasmodium falciparum parasites; although clears parasitemia shorter time periods than any other it does not cure infected patients; addition, causes side effects is rather expensive, important problems considering that...
Crystal packing patterns for a range of chloroquine derivatives have been investigated. For species where the amine-bound R substituent carries atoms not capable forming significant hydrogen bonding interactions, i.e. = methyl (1), n-propyl (2), n-butyl (3), 2-chloroethyl (4), 2-azidoethyl (5), N–H⋯N between amine and pyridine groups predominate leading to supramolecular chains. In carrying hydroxyl groups, 2-hydroxylethyl (6), 1-butanol (7), (S)-1-butanol (8), interactions are subverted by...
Ten new mefloquine-oxazolidine derivatives, 4-[(1S,8aR)-3-(aryl)hexahydro[1,3]oxazolo[3,4-a]pyridin-1-yl]-2,8-bis(trifluoromethyl)quinoline (1: aryl=substituted phenyl) and 4-[(1S,8aR)-3-(heteroaryl)hexahydro[1,3]oxazolo[3,4-a]pyridin-1-yl]-2,8-bis(trifluoromethyl)quinoline [2: heteroaryl=5-nitrothien-2-yl (2a); 5-nitrofuran-2-yl (2b) 4H-imidazol-2-yl) (2c)], have been synthesized evaluated against Mycobacterium tuberculosis. Compounds 1f (aryl=3-ethoxyphenyl), 1g...
The cestode E. multilocularis causes the disease alveolar echinococcosis (AE) in humans. continuously proliferating metacestode (larval stage) of parasite infects mostly liver and exhibits tumor-like growth. Current chemotherapeutical treatment options rely on benzimidazoles, which are rarely curative have to be applied daily life-long. This can result considerable hepatotoxicity thus discontinuation. Therefore, novel drugs against AE urgently needed. anti-malarial mefloquine was previously...
Abstract Human toxocariasis is a neglected parasitic disease with global distribution, treated current anthelmintics that have low to moderate efficacy, and requires the discovery of novel drugs. Camphor derivatives antimicrobial properties against various pathogens such as fungi bacteria. This study aimed identify camphor derivative activity Toxocara canis larvae evaluate its cytotoxicity, in silico bioavailability, vivo Swiss mice infected this parasite. Three compounds were tested vitro...