A5063116483- Immune Cell Function and Interaction
- Gut microbiota and health
- T-cell and B-cell Immunology
- Probiotics and Fermented Foods
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Asthma and respiratory diseases
- Research on Leishmaniasis Studies
- Food Allergy and Anaphylaxis Research
- Helicobacter pylori-related gastroenterology studies
- Diabetes and associated disorders
- Immunotherapy and Immune Responses
- Digestive system and related health
- Neuroinflammation and Neurodegeneration Mechanisms
- Infant Nutrition and Health
- Parasites and Host Interactions
- Inflammatory Bowel Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Trypanosoma species research and implications
- Oral health in cancer treatment
- Viral gastroenteritis research and epidemiology
- Eosinophilic Esophagitis
- Celiac Disease Research and Management
- COVID-19 Clinical Research Studies
- Immunodeficiency and Autoimmune Disorders
Universidade Federal de Minas Gerais
2016-2025
Universidade Federal do Rio Grande
2025
Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular
2021-2023
Fundação Oswaldo Cruz
2023
Instituto de Medicina Avançada
2020
Universidade Federal de Uberlândia
2009-2018
Institut des Sciences Biologiques
2018
Rockefeller University
2017
Universidade Estadual de Campinas (UNICAMP)
2009
Molina Center for Energy and the Environment
2009
Foxp3 + CD25 CD4 regulatory T cells are vital for peripheral tolerance and control of tissue inflammation. In this study, we characterized the phenotype monitored migration activity present in airways allergic or tolerant mice after allergen challenge. To induce lung inflammation, were sensitized twice with ovalbumin/aluminum hydroxide gel challenged intranasal ovalbumin. Tolerance was induced by oral administration ovalbumin 5 consecutive days prior to OVA sensitization We detected (Foxp3...
Background— Increasing evidence supports the involvement of inflammation and immunity in atherogenesis as well role autoimmunity to heat shock proteins (HSPs) progression atherosclerosis. Mucosal administration autoantigens decreases organ-specific disease several models (diabetes, arthritis, encephalomyelitis) is also being tested human clinical trials. Methods Results— We examined effect nasal or oral mycobacterial HSP-65 on atherosclerotic lesion formation mice lacking receptor for LDL...
Abstract Cell‐free DNA (cfDNA) is present in the circulating plasma and other body fluids known to originate mainly from apoptotic cells. Here, we provide first vivo evidence of global local chromatin changes human aging by analyzing cfDNA blood individuals different age groups. Our results show that nucleosome signals inferred are consistent with redistribution heterochromatin observed cellular senescence model systems. In addition, detected a relative loss at several genomic locations,...
Objective The effects of high‐refined carbohydrate‐containing diet (HC) on inflammatory parameters and metabolic disarrangement adipose tissue are poorly understood. aim this study was to evaluate the timing progression dysfunction induced by HC in mice. Design Methods BALB/c mice were fed chow or for 1 3 days, 1, 2, 4, 6, 8, 10, 12 weeks. Results Animals given exhibited acute sustained increase visceral adiposity, glucose intolerance, low insulin sensitivity, hyperlipemia, mRNA expression...
Many probiotic bacteria have been described as promising tools for the treatment and prevention of inflammatory bowel diseases (IBDs). Most these are lactic acid bacteria, which part healthy human microbiota. However, little is known about effects transient present in normal diets, including Lactococcus lactis.In study, we analysed immunomodulatory three L. lactis strains vitro using intestinal epithelial cells. NCDO 2118 was administered 4 days to C57BL/6 mice during remission period...
Hypertension is a major global health challenge, as it represents the main risk factor for stroke and cardiovascular disease. It multifactorial clinical condition characterized by high sustained levels of blood pressure, likely resulting from complex interplay endogenous environmental factors. The gut microbiota has been strongly supposed to be involved but its role in hypertension still poorly understood. In an attempt fill this gap, here we microbial composition fecal samples 48...
// Danielle Fernandes Durso 1, 2, * , Maria Giulia Bacalini 3, Claudia Sala 4, 9 Chiara Pirazzini 3 Elena Marasco 1 Massimiliano Bonafé Ítalo Faria do Valle 4 Davide Gentilini 5 Gastone Castellani Ana Caetano 6 Claudio Franceschi Paolo Garagnani 7, 8, 9, Christine Nardini 10, 11, Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum-University Bologna, Italy 2 National Counsel Technological Scientific Development (CNPq), Ministry Science Technology...
Excess intake of sodium is often associated with high risk for cardiovascular disease. More recently, some studies on the effects salt diets have also demonstrated that they are able to activate Th17 cells and increase severity autoimmune diseases. The purpose present study was evaluate a diet supplemented NaCl in colonic mucosa at steady state during inflammation. We showed consumption (HSD) by mice triggered gut inflammatory reaction IL-23 production, recruitment neutrophils increased...
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Systemic hyporesponsiveness occurs following oral administration of antigen (oral tolerance) and involves the uptake processing by gut-associated lymphoid tissue (GALT), which includes Peyer's patches (PP) lamina propria lymphocytes mesenteric lymph nodes (MLN). Animals with targeted mutations genes in tumor necrosis factor (TNF) family have differential defects development peripheral organs including PP MLN, provide a unique opportunity to investigate role GALT structures induction...
This study evaluated the relationship between ulcerative colitis and obesity, which are both chronic diseases characterized by inflammation increases in immune cells pro-inflammatory cytokines. Mice with induced 2 cycles of dextran sodium sulfate (DSS) first fourth week experiment were fed a high-fat diet (HFD) to induce obesity 8 weeks. The animals divided into 4 \ groups (control, colitis, HFD + HFD). Obesity alone did not raise histopathology scores, but combination worsened scores colon...
IL-10 is a regulatory cytokine that plays major role in the homeostasis of gut and this illustrated by fact IL-10(-/-) mice develop spontaneous colitis. In study, were analyzed for immunological changes during colitis development. We found reduced frequency T cells CD4(+)CD25(+)Foxp3(+) higher activated colon precedes macroscopic signs disease. Production IL-17 IFN-γ was colon. Colitis progression culminates with reduction CD4(+)LAP(+) intestine. Frequency B1 secretory IgA production both...
Several probiotic bacteria have been proposed for treatment or prevention of inflammatory bowel diseases (IBD), showing a protective effect in animal models experimental colitis and some them also human clinical trials. While most these are isolated from the digestive tract, we recently reported that Lactobacillus strain cheese, L. delbrueckii subsp. lactis CNRZ327 (Lb CNRZ327), possesses anti-inflammatory effects vitro vivo, demonstrating common dairy may be useful IBD. Here, studied...
Anti-LAP antibody induces antitumor immunity by affecting both adaptive and innate immune mechanisms.
Abstract Alterations in the composition of intestinal microbiota have been associated with development type 1 diabetes (T1D), but little is known about changes homeostasis that contribute to disease pathogenesis. Here, we analyzed oral tolerance induction, components barrier, fecal microbiota, and immune cell phenotypes non-obese diabetic (NOD) mice during progression compared resistant (NOR) mice. NOD failed develop had defective protective/regulatory mechanisms mucosa, including decreased...