A5002191815- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Asthma and respiratory diseases
- Neuropeptides and Animal Physiology
- Food Allergy and Anaphylaxis Research
- Cancer, Stress, Anesthesia, and Immune Response
- Biochemical Analysis and Sensing Techniques
- Circadian rhythm and melatonin
- Psoriasis: Treatment and Pathogenesis
- Diabetes and associated disorders
- Immunodeficiency and Autoimmune Disorders
- Olfactory and Sensory Function Studies
- Allergic Rhinitis and Sensitization
- Trypanosoma species research and implications
- Regulation of Appetite and Obesity
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Infant Health and Development
- Immune cells in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Women's cancer prevention and management
- Animal Nutrition and Physiology
- Cytomegalovirus and herpesvirus research
- Stress Responses and Cortisol
- Nigella sativa pharmacological applications
Universidade Federal de São Paulo
2012-2024
Fundação Faculdade de Medicina
2023
Brigham and Women's Hospital
2006-2008
Harvard University
2006-2008
Universidade de São Paulo
2001-2008
Universidad Nacional de Córdoba
2002
Foxp3 + CD25 CD4 regulatory T cells are vital for peripheral tolerance and control of tissue inflammation. In this study, we characterized the phenotype monitored migration activity present in airways allergic or tolerant mice after allergen challenge. To induce lung inflammation, were sensitized twice with ovalbumin/aluminum hydroxide gel challenged intranasal ovalbumin. Tolerance was induced by oral administration ovalbumin 5 consecutive days prior to OVA sensitization We detected (Foxp3...
Multiple sclerosis (MS) is a chronic relapsing disease of the central nervous system (CNS) in which immune processes are believed to play major role. To date, there no reliable method by characterize and their changes associated with different forms MS progression. We performed antigen microarray analysis patterns antibody reactivity serum against panel CNS protein lipid autoantigens heat shock proteins. Informatic consisted training set that was validated on blinded test set. The results...
Axonal degeneration is an important determinant of progressive neurological disability in multiple sclerosis (MS). Thus, therapeutic approaches promoting neuroprotection could aid the treatment MS. Here, we used what believe a novel water-soluble fullerene derivative (ABS-75) attached to NMDA receptor antagonist, which combines antioxidant and anti-excitotoxic properties, block axonal damage reduce disease progression chronic EAE model. Fullerene ABS-75 initiated after onset reduced clinical...
Adipose-derived mesenchymal stem cells (ADMSCs) display immunosuppressive properties, suggesting a promising therapeutic application in several autoimmune diseases, but their role type 1 diabetes (T1D) remains largely unexplored. The aim of this study was to investigate the immune regulatory properties allogeneic ADMSC therapy T cell–mediated NOD mice. treatment reversed hyperglycemia early-onset 78% diabetic mice, and effect associated with higher serum insulin, amylin, glucagon-like...
Beta2-adrenergic receptor (B2AR) signaling is known to impair Th1-cell differentiation and function in a cAMP-dependent way, leading inhibition of cell proliferation decreased production IL-2 IFN-γ. CD4(+) Foxp3(+) Treg cells play key role the regulation immune responses are essential for maintenance self-tolerance. Nevertheless, very little about adrenergic expression or influence noradrenaline on their function. Here we show that express functional B2AR. B2AR activation leads increased...
Leptin is an adipose‐secreted hormone that plays important role in both metabolism and immunity. has been shown to induce T h1‐cell polarization inhibit h2‐cell responses. Additionally, leptin induces h17‐cell responses, inhibits regulatory ( reg) cells modulates autoimmune diseases. Here, we investigated whether mediates its activity on by influencing dendritic DC s) promote h17 reg‐cell immune responses mice. We observed deficiency (i) reduced the expression of maturation markers, (ii)...
Abstract Despite accumulating evidence indicating that neurotransmitters released by the sympathetic nervous system can modulate activity of innate immune cells, we still know very little about how norepinephrine impacts signaling pathways in dendritic cells (DC) and consequence DC-driven T cell differentiation. In this article, demonstrate β2-adrenergic receptor (β2AR) activation LPS-stimulated DC does not impair their ability to promote proliferation; however, it diminishes IL-12p70...
We have previously shown that regulatory T (Treg) cells accumulate in the airways of allergic mice upregulate CC-chemokine receptor 4 (CCR4) expression. These Treg suppressed vitro Th2 cell proliferation but not type 2 cytokine production. In current study, using a well-established murine model lung disease or oral tolerance, we evaluated vivo activity airway inflammation with special focus on CCR4 function. found allergic, tolerant, treated anti-CD25 Ab showed increased eosinophilia and...
Noradrenaline (NE), the main neurotransmitter released by sympathetic nerve terminals, is known to modulate immune response. However, role of nervous system (SNS) on development autoimmune diseases still unclear. Here, we report that SNS limits generation pathogenic T cells and disease in experimental encephalomyelitis (EAE) model multiple sclerosis (MS). β2-Adrenergic receptor (Adrb2) signaling cell autoimmunity EAE through a mechanism mediated suppression IL-2, IFN-γ, GM-CSF production via...
Experimental autoimmune encephalomyelitis (EAE) has been widely employed as a model to study multiple sclerosis (MS) and indeed allowed some important advances in our comprehension of MS pathogenesis. Several pieces evidence suggest that infiltrating Th1 Th17 lymphocytes are players leading CNS demyelination lesion during the peak murine EAE. Subsequently, effector T cell responses rapidly decline recovery phase disease strongly correlates with expression anti-inflammatory cytokines...