A5037800313- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Stress Responses and Cortisol
- Paraoxonase enzyme and polymorphisms
- Maternal Mental Health During Pregnancy and Postpartum
- Smoking Behavior and Cessation
- Birth, Development, and Health
- Suicide and Self-Harm Studies
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Nicotinic Acetylcholine Receptors Study
- Obesity, Physical Activity, Diet
- Electrolyte and hormonal disorders
- Diet, Metabolism, and Disease
- Macrophage Migration Inhibitory Factor
- Hormonal Regulation and Hypertension
- Family Support in Illness
- Apelin-related biomedical research
- Diet and metabolism studies
- Cardiac Health and Mental Health
- Childhood Cancer Survivors' Quality of Life
- Child Abuse and Trauma
- Clinical Reasoning and Diagnostic Skills
- Medical research and treatments
- Liver Disease Diagnosis and Treatment
Universidade Estadual de Londrina
2013-2023
Entomological Society of Brazil
2018-2022
Chulalongkorn University
2014
To determine if oxidative stress and inflammation are linked with major depressive disorder, nicotine dependence both disorders combined. This study comprised 150 smokers 191 never smokers. The instruments were: a socio-demographic questionnaire, diagnoses of mood disorder according to DSM-IV, (SCID-IV), the Alcohol, Smoking Substance Involvement Screening Test. Laboratory assessments included: nitric oxide metabolites (NOx), lipid hydroperoxides, malondialdehyde (MDA), total reactive...
The top-down Diagnostic and Statistical Manual/International Classification of Diseases categories mood disorders are inaccurate, their dogmatic nature precludes both deductive (as indisputable) inductive top-down) remodelling case definitions. In trials, psychiatric rating scale scores employed as outcome variables invalid rely on folk psychology-like narratives. Using machine learning techniques, we developed a new precision nomothetic model with recurrence illness (ROI) index,...
Background Early life trauma (ELT) may drive mood disorder phenomenology, nitro-oxidative pathways and impairments in semantic memory. There are no data regarding the impact of ELT on affective phenomenology whether these mediated by staging or lowered lipid-associated antioxidant defences. Methods This study examined healthy controls (n=54) patients with disorders including major depression, bipolar anxiety (n=118). was assessed using Child Trauma Questionnaire. In addition, we measured...
Journal Article A Comparison of Inflammatory Markers in Depressed and Nondepressed Smokers Get access Sandra Odebrecht Vargas Nunes, M.D., Ph.D., Ph.D. 1Department Psychiatry, Health Sciences Center, Londrina State University, University Hospital, Londrina, Brazil Search for other works by this author on: Oxford Academic PubMed Google Scholar Heber Vargas, M.Sc., M.Sc. Juliana Brum, M.D. 2Cigarette Smoking Cessation Service, (UEL), Eduardo Prado, Mateus Mendonça Márcia Regina Pizzo de...
Objectives: Mood disorders (MDs) frequently co-exist with cardiovascular disease (CVD) and immune-inflammatory oxidative stress are important shared pathophysiological pathways. Even though there has been an extensive investigation of the enzyme paraoxonase 1 (PON1) as a biomarker susceptibility for CVD, few reports studying PON1 in MDs. The aim this study was to determine association between activities well functional genotypes MD diagnosis, clinical characteristics outcomes.Methods: were...
Abstract Rationale, aims Major affective disorders including bipolar disorder (BD) and major depressive (MDD) are associated with impaired health‐related quality of life (HRQoL). Oxidative stress subtle thyroid abnormalities may play a pathophysiological role in both disorders. Thus, the current study was performed to examine whether neuro‐oxidative biomarkers thyroid‐stimulating hormone (TSH) levels could predict HRQoL BD MDD. Methods This cross‐sectional enrolled 68 37 MDD patients 66...
Objectives This study examined cognition-immune interactions, specifically executive function, working memory, peripheral levels of tumour necrosis factor-alpha (TNF-α), and soluble factor receptors-1 −2 (sTNFR1 2) in bipolar disorder (BD) patients comparison with controls.Methods Thirty-one BD participants twenty-seven controls participated the study. The neurocognitive assessment was performed through three CogState Research BatteryTM tasks for function memory. Plasma TNF-α, sTNFR1, sTNFR2...
Nicotine dependence is associated with an increased risk of mood and anxiety disorders suicide. The primary hypothesis this study was to identify whether the polymorphisms two glutathione-S-transferase enzymes (GSTM1 GSTT1 genes) predict in smokers nicotine dependence.Smokers were recruited at Centre Treatment for Smokers. instruments a sociodemographic questionnaire, Fagerström Test Dependence, diagnoses disorder according DSM-IV (SCID-IV), Alcohol, Smoking Substance Involvement Screening...