A5064433833- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Circadian rhythm and melatonin
- Health Systems, Economic Evaluations, Quality of Life
- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Diet and metabolism studies
- Pharmaceutical Practices and Patient Outcomes
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Healthcare Policy and Management
- Geriatric Care and Nursing Homes
- Maternal Mental Health During Pregnancy and Postpartum
- Autism Spectrum Disorder Research
- Neuroendocrine regulation and behavior
- Parkinson's Disease Mechanisms and Treatments
- Birth, Development, and Health
- Neuroscience and Neuropharmacology Research
- Emergency and Acute Care Studies
- Gut microbiota and health
- Neuroinflammation and Neurodegeneration Mechanisms
- Primary Care and Health Outcomes
- Attention Deficit Hyperactivity Disorder
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmaceutical studies and practices
- Blood Pressure and Hypertension Studies
University of the West of Scotland
2025
Yale University
1996-2024
University of Toronto
2011-2024
Sun Yat-sen University
2023
Sun Yat-sen University Cancer Center
2023
Brown University
2023
University of Global Health Equity
2022
Harvard University
2006-2022
Partners In Health
2022
Brigham and Women's Hospital
2006-2022
Background: Antipsychotic drugs are widely used to manage behavioral and psychological symptoms in dementia despite concerns about their safety. Objective: To examine the association between treatment with antipsychotics (both conventional atypical) all-cause mortality. Design: Population-based, retrospective cohort study. Setting: Ontario, Canada. Patients: Older adults who were followed 1 April 1997 31 March 2003. Measurements: The risk for death was determined at 30, 60, 120, 180 days...
The existence and importance of excitement in gambling, the effects runs wins losses on gambling behaviour relationships both with sensation‐seeking were investigated using samples students experienced gamblers real artificial situations. Heart‐rate increases, events such as ‘stake decision time’ recorded subjects played blackjack. Significant differences between casinos found for mean heart‐rate increases over base‐lines, sensation‐seeking, arousal two conditions. Doubt is cast laboratory a...
Background: Cholinesterase inhibitors are commonly prescribed to treat dementia, but their adverse effect profile has received little attention.These drugs can provoke symptomatic bradycardia and syncope, which may lead permanent pacemaker insertion.Drug-induced syncope also precipitate fall-related injuries, including hip fracture.Methods: In a population-based cohort study, we investigated the relationship between cholinesterase inhibitor use syncope-related outcomes using health care...
There is increasing interest in the effect of cardiovascular disease on cancer survivors. However, there are limited contemporary population-based data risk death after early-stage breast cancer.To describe incidence a population women with while accounting for competing risks.A cohort study was conducted among 98 999 diagnosed between April 1, 1998, and March 31, 2012. Patients were followed up until or censored December 2013. Baseline characteristics determined from administrative...
<h3>Background</h3> Recent debate has emerged regarding the cardiovascular safety of selective cyclooxygenase 2 inhibitors and possible cardioprotective effect naproxen sodium. We compared rates acute myocardial infarction (AMI) among elderly patients dispensed inhibitors, naproxen, nonselective nonnaproxen nonsteroidal anti-inflammatory drugs (NSAIDs). <h3>Methods</h3> conducted a population-based retrospective cohort study using administrative health care data from Ontario, Canada, April...
To compare rates of upper gastrointestinal haemorrhage among elderly patients given selective cyclo-oxygenase-2 (COX 2) inhibitors and non-selective non-steroidal anti-inflammatory drugs (NSAIDs).Observational cohort study.Administrative data from Ontario, Canada, used 17 April 2000 to 31 March 2001 identify population based, NSAID-naive cohorts patients.Subjects aged > or =66 years who started taking NSAIDs (n=5391), diclofenac plus misoprostol (n=5087), rofecoxib (n=14 583), celecoxib...
OBJECTIVES: To obtain population‐based estimates of emergency department (ED) visits by long‐term care (LTC) residents. DESIGN: Retrospective cohort study using administrative data. SETTING: All LTC facilities in Ontario, Canada. PARTICIPANTS: residents who visited an ED at least once during a 6‐month period. MEASUREMENTS: were described the National Ambulatory Care Reporting System. Two distinct visit types defined. Potentially preventable defined as those for any ambulatory sensitive...
Abstract Background Alzheimer’s disease (AD) involves increased accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles as well neuronal loss in various regions the neocortex. Neuroinflammation is also present, but its role AD not fully understood. We previously showed levels pro-inflammatory cytokine interleukin-18 (IL-18) different brains, where it co-localized with Aβ-plaques, ability IL-18 to increase expression glycogen synthase kinase-3β (GSK-3β) cyclin dependent kinase 5,...
Although many people are exposed to trauma, only some individuals develop posttraumatic stress disorder; most do not. It is possible that humans differ in the degree which induces neurobiological perturbations of their threat response systems, may result a differential capacity cope with aversive experiences. This study explored idea differences responses significantly related psychological and behavioral indices.Individual neurohormonal, psychological, performance indices among 44 healthy...
<h3>Abstract</h3> <b>Objectives</b> To quantify the influence of physicians9 experiences adverse events in patients with atrial fibrillation who were taking warfarin. <b>Design</b> Population based, matched pair before and after analysis. <b>Setting</b> Database study Ontario, Canada. <b>Participants</b> The physicians admitted to hospital for (major haemorrhage while warfarin thromboembolic strokes not warfarin). Pairs other treated by same selected. <b>Main outcome measures</b> Odds...
We analyzed the records of 454,668 births in Ontario years 1979 to 1982 and found that cesarean birth rate increased from 16.5 per hundred deliveries 18.7 1982. Cesarean were classified according four indications: previous birth, breech presentation, dystocia, fetal distress. The increase for each indication was calculated expressed as a percentage total increase. Previous accounted 68 cent increase, presentation 14 cent, dystocia 4 distress cent. impact indicated by an number women...
Antibiotics are frequently and often inappropriately prescribed to patients in nursing homes. These antibiotics pose direct risks recipients indirect others residing the home.To examine whether living a home with high antibiotic use is associated an increased risk of antibiotic-related adverse outcomes for individual residents.In this longitudinal open-cohort study performed from January 1, 2010, through December 31, 2011, we studied 110,656 older adults 607 homes Ontario, Canada.Nursing...