A5073942392- Adipose Tissue and Metabolism
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Regulation of Appetite and Obesity
- Hormonal Regulation and Hypertension
- Neuropeptides and Animal Physiology
- Diet and metabolism studies
- Birth, Development, and Health
- Menstrual Health and Disorders
- Diet, Metabolism, and Disease
- Hedgehog Signaling Pathway Studies
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Hypothalamic control of reproductive hormones
- Estrogen and related hormone effects
- Ovarian function and disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience of respiration and sleep
- Heart Rate Variability and Autonomic Control
- Muscle metabolism and nutrition
- Parkinson's Disease Mechanisms and Treatments
- Apelin-related biomedical research
- Neonatal and fetal brain pathology
- Metabolism and Genetic Disorders
Universidade Estadual de Londrina
2015-2025
Glucocorticoids increase appetite and body weight gain in rats ovariectomy (OVX) induces obesity, while estrogen (E) replacement attenuates OVX-induced changes. It is known that animals with obesity are more responsive to glucocorticoids anabolic effects than lean ones. This study aimed evaluate the of protective role estradiol on responses induced by prolonged treatment corticosterone or dexamethasone energy homeostasis. For this, female Wistar subjected SHAM OVX surgery, composing SHAM,...
Glucocorticoids (GC) increase food intake and body weight in humans rodents chronic stress GC treatment-induced enhancement of the plasma concentration lead to obesity metabolic changes. In response hypercaloric treatment, males were shown be more susceptible than females, demonstrating that sex differences may affect energy homeostasis. The objective current study was evaluate effects prolonged (28 days) treatment with dexamethasone or corticosterone on gain intact rats, both male female....
The important involvement of the suprachiasmatic nucleus (SCN) and activity vasopressinergic neurons in maintaining rhythmicity female reproductive system depends on mRNA transcription-translation feedback loops. Therefore, circadian clock function, like most physiological processes, is involved events that determine aging. This study describes change expression genes, Per2 , Bmal1 Rev-erbα hypothalamus-pituitary-gonadal axis (HPG) rats with regular cycle (RC) irregular (IC), SCN kisspeptin...
Abstract Aim Parkinson's disease (PD) is a progressive neurodegenerative that manifests itself clinically after reaching an advanced pathological stage. Besides motor signals, PD patients present cardiovascular and autonomic alterations. Recent data showed rats induced to Parkinsonism by 6‐hydroxydopamine (6‐OHDA) administration in the substantia nigra pars compacta (SNpc) lower mean arterial pressure (MAP) heart rate (HR), as reduction sympathetic modulation. The paraventricular nucleus of...
Metabolic programming may be induced by reduction or enhancement of litter size, which lead to neonatal over undernutrition, respectively. Changes in nutrition can challenge some regulatory processes adulthood, such as the hypophagic effect cholecystokinin (CCK). In order investigate effects nutritional on anorexigenic function CCK pups were raised small (SL, 3 per dam), normal (NL, 10 large litters (LL, 16 and postnatal day 60, male rats treated with vehicle (10 µg/Kg) for evaluation food...
Nutritional status during critical windows in early development can challenge metabolic functions and physiological responses to immune stress adulthood, such as the systemic inflammation induced by lipopolysaccharide (LPS). The aim of this study was investigate long-term effects post-natal over- undernutrition on anorexigenic effect LPS its association with neuronal activation brainstem hypothalamus male rats. Animals were raised litters 3 (small - SL), 10 (normal NL), or 16 (large LL) pups...
O meduloblastoma é um tumor cerebelar caracterizado como neuroectodérmico primitivo prevalente em crianças, sendo as do sexo masculinos mais afetadas. Com relação à classificação histológica, existem cinco variações: clássico, desmoplásico, anaplásico, células gigantes e de extensa nodularidade. Muitos estudos relatam que a patogênese está relacionada com mutações fatores crescimento SNC, principais vias envolvidas são: Sonic Hedgehog, NOTCH, WNT OTX. Ainda, respeito imunologia, pacientes...
O meduloblastoma é um tumor cerebelar caracterizado como neuroectodérmico primitivo prevalente em crianças, sendo as do sexo masculinos mais afetadas. Com relação à classificação histológica, existem cinco variações: clássico, desmoplásico, anaplásico, células gigantes e de extensa nodularidade. Muitos estudos relatam que a patogênese está relacionada com mutações fatores crescimento SNC, principais vias envolvidas são: Sonic Hedgehog, NOTCH, WNT OTX. Ainda, respeito imunologia, pacientes...
Introduction: Lactation overnutrition is a programming agent of energy metabolism, and litter size reduction leads to the early development obesity, which persists until adulthood. Liver metabolism disrupted by increased levels circulating glucocorticoids are pointed as possible mediator for obesity development, since bilateral adrenalectomy (ADX) can reduce in different models obesity. Methods: This study aimed evaluate effects on metabolic changes liver lipogenesis insulin pathway induced...
Background and Aims: Metabolic syndrome (MS) is a condition characterized by endocrine-metabolic cardiac alterations, which increase the risk of cardiovascular disease, dyslipidemia, type 2 diabetes mellitus. Studies have shown that dietary supplementation with l-arginine (l- arg) beneficial for fat loss, as well several benefits chronic aerobic exercise in reversing cardiovascular, autonomic, metabolic dysfunctions due to obesity been observed. However, association both approaches has not...