A5103759409- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Melanoma and MAPK Pathways
- Amphibian and Reptile Biology
- Cancer Genomics and Diagnostics
- Histone Deacetylase Inhibitors Research
- Primate Behavior and Ecology
- Birth, Development, and Health
- Cutaneous Melanoma Detection and Management
- Mosquito-borne diseases and control
- Genomics and Chromatin Dynamics
- Hemoglobin structure and function
- Agricultural and Food Sciences
- Ferroptosis and cancer prognosis
- melanin and skin pigmentation
- Botanical Research and Applications
- Banana Cultivation and Research
- Microbial infections and disease research
- Fish biology, ecology, and behavior
- Wildlife-Road Interactions and Conservation
- Thermography and Photoacoustic Techniques
- Food Waste Reduction and Sustainability
- Crop Yield and Soil Fertility
- RNA modifications and cancer
Universidade Estadual de Londrina
2025
Universidade Federal de Santa Catarina
2023-2024
Universidade Federal de São Paulo
2010-2021
Universidade de São Paulo
2016-2018
Henry Ford Health System
2017-2018
Universidade Federal de Viçosa
2018
Henry Ford Hospital
2017
University of Évora
2013
Secretaria do Meio Ambiente
2012
Universidade Estadual de Maringá
2011
Glioma diagnosis is based on histomorphology and grading; however, such classification does not have predictive clinical outcome after glioblastomas developed. To date, no bona fide biomarkers that significantly translate into a survival benefit to glioblastoma patients been identified. We previously reported the IDH mutant G-CIMP-high subtype would be predecessor G-CIMP-low subtype. Here, we performed comprehensive DNA methylation longitudinal analysis of diffuse gliomas from 77 (200...
Significance Identifying the drivers of tumorigenesis provides insight into mechanisms transformation and can suggest novel therapeutic targets. IDH1 mutations in gliomas are one such promising target. Drivers tumor initiation may be distinct from those at recurrence, however. Here, we demonstrate that a subset initially mutant is deleted or amplified yielding higher grade with reprogrammed epigenome. We also report systematic selection for cells CNA vitro vivo. Thus, while mutation likely...
O iogurte é um produto funcional derivado do leite que pode exercer papel importante no organismo. A região norte Brasil se destaca na criação de bubalinos, e o presente trabalho tem como objetivo produzir natural a partir búfala da Amazônia, avaliando suas propriedades organolépticas, composição centesimal nutricional. metodologia empregada incluiu produção iogurte, análise umidade, gorduras, carboidratos, proteínas, cinzas cálcio, além comparação com marcas comerciais iogurte. Os...
Melanoma progression requires deregulation of gene expression by currently uncharacterized epigenetic mechanisms. A mouse model based on changes in cell microenvironment was developed our group to study melanocyte malignant transformation. lines (4C11- and 4C11+) were obtained as result 5 sequential anchorage blockades non-tumorigenic melan-a melanocytes. Melan-a cells submitted 4 de-adhesion cycles also established (4C), are represent an intermediary phase tumor progression. The aim this...
Hemorrhagic shock (HS), which causes insufficient tissue perfusion, can result in multiple organ failure (MOF) and death. This study aimed to evaluate whether doxycycline (DOX) protects cardiovascular, kidney, liver from damage a rat model of HS. Immediately before the resuscitation, DOX (10 mg/kg; i.v.) was administered, its protective effects were assessed 24 h later. Mean arterial pressure, renal blood flow, heart rate, vasoactive drug response, markers such as urea, creatinine, AST, ALT,...
Abstract Nutritional status during the developmental periods leads to predisposition several diseases and comorbidities, highlighting metabolic reproductive changes throughout adult life, in next generations. One of experimental models used induce undernutrition is litter size expansion, which decreases availability breast milk pups delays development. This work evaluated effects maternal induced by a preconception model, on alterations offspring. For this, parameters were male female...
Fifty-eight blue-fronted Amazon parrot (Amazona aestiva) nestlings, recovered from the illegal trade, became ill at a wildlife rehabilitation center in São Paulo State, Brazil. Clinical signs observed were nonspecific, and mortality rate was 96.5% despite initial treatment with norfloxacin. Postmortem examinations performed on 10 birds. Liver spleen smears showed structures suggestive of Chlamydophila psittaci four cases. Diagnosis confirmed by seminested polymerase chain reaction tissue...
Metastatic melanoma is a highly aggressive skin cancer and currently resistant to systemic therapy. Melanomas may involve genetic, epigenetic metabolic abnormalities. Evidence emerging that changes might play significant role in tumor cell plasticity metastatic phenotype of cells.In this study, we developed systematic approach identify genes implicated progression. To do this, used the Affymetrix GeneChip Arrays screen 34,000 mouse transcripts melan-a melanocytes, 4C pre-malignant 4C11-...
Melanoma is a human neurocristopathy associated with developmental defects in the neural crest-derived epidermal melanocytes. At present time, at least three hypotheses were identified that may explain melanoma aetiology, as follows: (1) model of linear progression from differentiated melanocytes to metastatic cancer cells (2) involving appearance stem-like cells, and (3) an epigenetic progenitor cancer. Treating one most serious challenges 21st century. This justified because subpopulation...
We provide here a current overview of marmoset (Callithrix) evolution, hybridization, species biology, basic/biomedical research, and conservation initiatives. Composed two subgroups, the aurita group (C. C. flaviceps) jacchus geoffroyi, jacchus, kuhlii penicillata), this relatively young primate radiation is endemic to Brazilian Cerrado, Caatinga, Atlantic Forest biomes. Significant impacts on Callithrix within these biomes resulting from anthropogenic activity include: (1) population...
The present study provides a record of the bat fauna captured in Guarulhos, state São Paulo, Brazil, between February and November 2011. capture sessions were carried out using mist nets set on trails, around above streams lakes, near built areas livestock. After total effort 26,208 m2.h, we recorded 17 species belonging to Phyllostomidae (13 species), Vespertilionidae (3) Molossidae (1). Sturnira lilium (73 captures), Artibeus fimbriatus (69), A. lituratus (59) most abundant species,...
The handling of turtles and other reptiles can be associated with risk pathogenic enterobacteria transmission, mainly Salmonella spp. aim this study was to identify the in cloacal swabs 39 red-eared sliders (Trachemys scripta elegans). Cloacal from captive individuals were analyzed. After sample enrichment brain-heart infusion broth 1% peptone water, bacterial isolation performed through cultivation blood, MacConkey xylose lysine desoxycholate agar. Bacterial identification achieved...
Gliomas are a heterogeneous group of brain tumors with distinct biological and clinical properties. Despite advances in surgical techniques regimens, treatment high-grade glioma remains challenging carries dismal rates therapeutic success overall survival. Challenges include the molecular complexity gliomas, as well inconsistencies histopathological grading, resulting an inaccurate prediction disease progression failure use standard therapy. The updated 2016 World Health Organization (WHO)...
Despite advances in therapeutics, the progression of melanoma to metastasis still confers a poor outcome patients. Nevertheless, there is scarcity biological models understand cellular and molecular changes taking place along disease progression. Here, we characterized transcriptome profiles multi-stage murine model comprising nontumorigenic melanocyte lineage (melan-a), premalignant melanocytes (4C), nonmetastatic (4C11-) metastasis-prone (4C11+) cells. Clustering analyses have grouped 4...
SUMMARY Histomorphology and current grading schemes are unable to predict glioma relapse malignant tumor progression. We reported that the IDH-mutant associated Glioma-CpG Island Methylator Phenotype (G-CIMP) can be further divided into two clinically distinct subtypes independent of histopathological (G-CIMP-high -low) with evidence correlation Here we performed a comprehensive epigenomic analysis 74 longitudinally collected samples (grade II-IV) understand recurrence from G-CIMP-high...
A Pereskia spp. é uma hortaliça não convencional perene da família Cactaceae, distribuída nas Américas e que possui folhas, flores frutos comestíveis. Suas folhas contêm teores significativos de proteína, fibras carboidratos, sendo referida como “bife vegetal”. Considerando a importância necessidade novas fontes proteínas para consumo humano, o objetivo deste trabalho foi avaliar composição centesimal das diferentes clones ora-pro-nóbis. Os ramos foram coletados em plantas cultivadas na...
New tomato lines adapted to Amazonian conditions have been developed by the National Institute for Research, but not yet evaluated hydroponic cultivation. The aim of this study was evaluate production these in a system municipality Manaus-AM. experiment carried out at Hidroponia Green Health (02°58'26.35“ S and 60°04'39.94” W), greenhouse, using NFT (Nutrient Film Technique) during rainy season (January April). A PLANTPAR nutrient solution were used vegetative phase another productive phase,...