A5032364136- Regulation of Appetite and Obesity
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Neuroscience of respiration and sleep
- Birth, Development, and Health
- Neuropeptides and Animal Physiology
- Biochemical Analysis and Sensing Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Hormonal Regulation and Hypertension
- Diet and metabolism studies
- Circadian rhythm and melatonin
- Dietary Effects on Health
- Sleep and Wakefulness Research
- Thermoregulation and physiological responses
- Hypothalamic control of reproductive hormones
- Infant Health and Development
- Ovarian function and disorders
- Menstrual Health and Disorders
- Enhanced Recovery After Surgery
- Diet, Metabolism, and Disease
- Cannabis and Cannabinoid Research
- Electrolyte and hormonal disorders
- Pancreatic function and diabetes
- Sexual function and dysfunction studies
Universidade Estadual de Londrina
2016-2025
Universidade de São Paulo
2010-2021
Universidade de Ribeirão Preto
2016-2021
Hospital Bandeirantes
2008
Metabolic endotoxemia contributes to low-grade inflammation in obesity, which causes insulin resistance due the activation of intracellular proinflammatory pathways, such as c-Jun N-terminal Kinase (JNK) cascade hypothalamus and other tissues. However, it remains unclear whether process precedes or appears because development obesity. Hypothalamic was induced by prolonged lipopolysaccharide (LPS) exposure investigate if central is an inflammatory stimulus regardless Male Wistar rats were...
Abstract Nutritional status during the developmental periods leads to predisposition several diseases and comorbidities, highlighting metabolic reproductive changes throughout adult life, in next generations. One of experimental models used induce undernutrition is litter size expansion, which decreases availability breast milk pups delays development. This work evaluated effects maternal induced by a preconception model, on alterations offspring. For this, parameters were male female...
Ethanol (ETOH) consumption has been associated with endocrine and autonomic changes, including the development of hypertension. However, sequence pathophysiological events underlying emergence this effect is poorly understood. Aims: This study aimed to establish a time-course correlation between neuroendocrine cardiovascular changes contributing hypertension following ETOH consumption. Methods: Male adult Wistar rats were subjected intake increasing concentrations in their drinking water...
Glucocorticoids have major effects on food intake, demonstrated by the decrease of intake following adrenalectomy. Satiety signals are relayed to nucleus solitary tract (NTS), which has reciprocal projections with arcuate (ARC) and paraventricular (PVN) hypothalamus. We evaluated glucocorticoids activation hypothalamic NTS neurons induced in rats subjected adrenalectomy (ADX) or sham surgery 7 days before experiments. One-half ADX animals received corticosterone (ADX+B) drinking water (B: 25...
Food access restriction is associated to changes in gene expression of the circadian clock system. However, there are only a few studies investigating effects non-photic synchronizers, such as food entrainment, on genes central oscillators. We hypothesized that different feeding patterns could modulate suprachiasmatic nucleus (SCN) "master" and extra-SCN oscillators paraventricular (PVN) arcuate (ARC) hypothalamic nuclei. Wistar rats were divided into four groups: Control group (CG;...
The aim of the present work was to establish a time-course correlation between vascular and autonomic changes that contribute development hypertension during ethanol ingestion in rats. For this, male Wistar rats were subjected intake increasing concentrations their drinking water four weeks. Ethanol effects investigated at end each week. Mild already observed first week treatment, progressive blood pressure increase along evaluation period. Increased pressor response phenylephrine from...
Leptin resistance is induced by the feedback inhibitors tyrosine phosphatase-1B (PTP1B) and decreased Src homology 2 domain-containing phosphatase-2 (SHP-2) signaling. To investigate participation of PTP1B SHP-2 in LPS-induced leptin resistance, we injected repeated (6-LPS) intraperitoneal LPS doses (100 μg/kg ip) for comparison with a single (1-LPS) treatment evaluated expression SHP-2, PTP1B, p-ERK1/2, p-STAT3 hypothalamus male Wistar rats. The increased but not SHP-2. reduced did change...
In rodents, kisspeptin neurons in the rostral periventricular area of third ventricle (RP3V) preoptic are considered to provide a major stimulatory input GnRH neuronal network that is responsible for triggering preovulatory LH surge. Noradrenaline (NA) one main modulators release, and NA fibers found close apposition RP3V. Our objective was interrogate role signaling control secretion during estradiol induced surge ovariectomized rats, using prazosin, an α1-adrenergic receptor antagonist....
The endocannabinoid system includes important signaling molecules that are involved in several homeostatic and neuroendocrine functions. In the present study, we evaluated effects of type 1 cannabinoid (CB(1)) receptor antagonist, rimonabant (10 mg/kg, p.o.), on hormone secretion, neuronal activation mRNA expression hypothalamus following isotonic (I-) or hypertonic (H-) extracellular volume expansion (EVE). total nitrate content PVN SON was also assessed under same experimental conditions....
Glucocorticoids have major effects on food intake, as demonstrated by the decrease of intake following adrenalectomy (ADX); however, mechanisms leading to these are not well understood. Oxytocin (OT) has been shown reduce intake. We evaluated glucocorticoids OT neuron activation and mRNA expression in hypothalamic paraventricular (PVN) supraoptic (SON) nuclei induced feeding. also effect pretreatment with OT-receptor antagonist ([d(CH2)5,Tyr(Me)2,Orn8]-vasotocin, OVT) ADX rats. Fos/OT...
The present study provides the first in vivo evidence that cannabinoid CB(1) receptor mediates effects of dexamethasone on hormone release induced by changes circulating volume and osmolality. Male adult rats were administered with antagonist rimonabant (10 mg/Kg, p.o.), followed or not 1 hour (1 i.p.). Extracellular expansion (EVE, 2 mL/100 g body weight, i.v.) was performed hours after vehicle treatment using either isotonic (I-EVE, 0.15 mol/L) hypertonic (H-EVE, 0.30 NaCl solution. Five...
Glucocorticoids increase appetite and body weight gain in rats ovariectomy (OVX) induces obesity, while estrogen (E) replacement attenuates OVX-induced changes. It is known that animals with obesity are more responsive to glucocorticoids anabolic effects than lean ones. This study aimed evaluate the of protective role estradiol on responses induced by prolonged treatment corticosterone or dexamethasone energy homeostasis. For this, female Wistar subjected SHAM OVX surgery, composing SHAM,...
Anorexia is a common clinical manifestation of primary adrenal gland failure. Adrenalectomy (ADX)-induced hypophagia reversed by oxytocin (OT) receptor antagonist and associated with increased activation satiety-related responses in the nucleus solitary tract (NTS). This study evaluated OT projections from paraventricular hypothalamus (PVN) to NTS after ADX effect pretreatment intracerebroventricular injection an ([d(CH2)5,Tyr(Me)(2),Orn(8)]-vasotocin; OVT) on neurons induced feeding...
Hypophagia induced by inflammation is associated with Janus kinase (JAK)-2/signal transducer and activator of transcription (STAT) 3 signaling pathway, leptin-mediated hypophagia also mediated JAK2-STAT3 pathway. We have previously reported that lipopolysaccharide (LPS) did not reduce food intake in leptin-resistant high-fat diet (HFD) rats but maintained body weight loss. investigated whether changes p-STAT3 expression the hypothalamus brain stem could account for desensitization HFD...
(1) The aim of the present study was to evaluate effects intracerebroventricular administration anandamide (AEA), an inhibitor fatty acid amide hydrolase activity (URB597) and a CB1 receptor (CB1 R) antagonist (AM251) on homeostatic responses elicited by extracellular volume expansion (EVE) in male adult rats. (2) Pretreatment with AEA (100 ng/4 μL) significantly reduced effect hypertonic (H-) EVE plasma concentrations prolactin (PRL), oxytocin (OT) corticosterone, but not vasopressin (AVP)....
Adrenalectomy-induced hypophagia is associated with increased satiety-related responses, which involve neuronal activation of the nucleus solitary tract (NTS). Besides its effects on pituitary-adrenal axis, corticotrophin-releasing factor (CRF) has been shown to play an important role in feeding behaviour, as it possesses anorexigenic effects. We evaluated feeding-induced CRF mRNA expression paraventricular (PVN) and pretreatment CRF(2) receptor antagonist (Antisauvagine-30, AS30) food...
The present study investigated the type 1 cannabinoid receptor (CB1R) as a potential candidate to mediate homeostatic responses triggered by 24 h of water deprivation, which constitutes primarily hydroelectrolytic challenge and also significantly impacts energy homeostasis. results demonstrated for first time that CB1R mRNA expression is increased in hypothalamus water-deprived (WD) rats. Furthermore, administration ACEA, selective agonist, potentiated WD-induced dipsogenic effect, whereas...
Glucocorticoids (GC) increase food intake and body weight in humans rodents chronic stress GC treatment-induced enhancement of the plasma concentration lead to obesity metabolic changes. In response hypercaloric treatment, males were shown be more susceptible than females, demonstrating that sex differences may affect energy homeostasis. The objective current study was evaluate effects prolonged (28 days) treatment with dexamethasone or corticosterone on gain intact rats, both male female....