A5050563382- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Nitric Oxide and Endothelin Effects
- Biochemical effects in animals
- Eicosanoids and Hypertension Pharmacology
- Neuropeptides and Animal Physiology
- Circadian rhythm and melatonin
- Ion channel regulation and function
- Alcohol Consumption and Health Effects
- Tryptophan and brain disorders
- Hormonal Regulation and Hypertension
- Birth, Development, and Health
- Nicotinic Acetylcholine Receptors Study
- Vagus Nerve Stimulation Research
- Diet and metabolism studies
- Neurogenesis and neuroplasticity mechanisms
- Regulation of Appetite and Obesity
Universidade de São Paulo
2015-2024
Universidade de Ribeirão Preto
2013-2023
National Council for Scientific and Technological Development
2023
Clinics Hospital of Ribeirão Preto
2008-2016
Zero to Three
2009
Background and purpose: Cannabidiol (CBD) is a non‐psychotomimetic compound from Cannabis sativa which induces anxiolytic‐ antipsychotic‐like effects in rodents. These could be mediated by facilitation of the endocannabinoid system or activation 5‐HT 1A receptors. As either these mechanisms promote adaptation to inescapable stress, aim present work was test hypothesis that CBD would attenuate autonomic behavioural consequences restraint stress (RS). We also investigated if responses depended...
Cannabidiol (CBD) is a major nonpsychotomimetic component of Cannabis sativa that has been shown to have an anxiolytic effect in human and animal models. Earlier studies suggest these effects involve facilitation serotonin, neurotransmitter also related obsessive–compulsive disorder. On the basis this evidence, study investigated CBD C57BL/6J mice submitted marble-burying test (MBT), model proposed reflect compulsive behaviour. (15, 30 60 mg/kg) induced significant decrease number buried...
Abstract The ventral medial prefrontal cortex (vMPFC) comprises the prelimbic (PL) and infralimbic (IL). Conflicting results have been reported from studies aiming to investigate role played by vMPFC in behavioral autonomic responses evoked rodents exposed experimental protocols that promote defense responses. Acute restraint is an unavoidable stress situation evokes marked sustained cardiovascular changes, which are characterized elevated blood pressure (BP) intense heart rate (HR)...
The ventral portion of the medial prefrontal cortex (vMPFC) has been related to expression contextual fear conditioning. This study investigated possible involvement CB1 receptors in this aversive response. Male Wistar rats were submitted a conditioning session and 48 h later re-exposed context which freezing cardiovascular responses (increase arterial pressure heart rate) recorded. receptor-mRNA vMPFC was also measured using real time-PCR. In first experiment intra-vMPFC administration...
Obsessive–compulsive disorder (OCD) is a common psychiatric characterized by the occurrence of obsessions and compulsions. Glutamatergic abnormalities have been related to pathophysiology OCD. Cannabinoids inhibit glutamate release in central nervous system, but involvement drugs targeting endocannabinoid system has not yet tested animal models repetitive behavior. Thus, aim present study was verify effects CB1 receptor agonist WIN55,212-2, inhibitor anandamide uptake AM404 hydrolysis...
Background:Inducible or neuronal nitric oxide synthase gene deletion increases decreases anxiety-like behavior in mice, respectively. Since and endocannabinoids interact to modulate defensive behavior, the former effect could involve a compensatory increase basal brain activity and/or changes endocannabinoid system. Thus, we investigated expression extinction of contextual fear conditioning inducible knockout mice possible involvement these responses.
In the present study, we evaluated cardiac baroreflex responses of rats submitted to acute restraint stress. The was tested: immediately before, during a 30 min exposure stress, as well and 60 after ending stress session (recovery period). Restraint increased both mean arterial pressure (MAP) heart rate (HR). magnitude tachycardiac evoked by intravenous infusion sodium nitroprusside higher whereas that bradycardiac phenylephrine decreased. Restraint-evoked changes were still observed at into...