Carlos Frederico Martins Menck
A5079483159- DNA Repair Mechanisms
- Carcinogens and Genotoxicity Assessment
- CRISPR and Genetic Engineering
- Skin Protection and Aging
- bioluminescence and chemiluminescence research
- Metabolism and Genetic Disorders
- Virus-based gene therapy research
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- Light effects on plants
- Mitochondrial Function and Pathology
- Bone and Dental Protein Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer-related Molecular Pathways
- Plant Pathogenic Bacteria Studies
- Cancer therapeutics and mechanisms
- Genomics and Phylogenetic Studies
- Bacteriophages and microbial interactions
- Photosynthetic Processes and Mechanisms
- Bacterial Genetics and Biotechnology
- Plant Genetic and Mutation Studies
- Photodynamic Therapy Research Studies
- Autophagy in Disease and Therapy
- Pluripotent Stem Cells Research
- Animal Genetics and Reproduction
Universidade de São Paulo
2016-2025
Institute of Biomedical Science
2005-2022
Hospital Universitário da Universidade de São Paulo
2008-2019
Fundação Carlos Chagas
2018
Instituto de Biofísica Carlos Chagas Filho
2018
Universidade Federal do Rio de Janeiro
2004-2018
Nobel Foundation
2015
Universidade Federal de São Paulo
2015
Mendelics
2015
Ciência Viva
2015
We present a draft sequence of the genome Aedes aegypti, primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times size malaria Anopheles gambiae. Nearly 50% Ae. aegypti consists transposable elements. These contribute to factor 4 6 increase in average gene length sizes intergenic regions relative An. gambiae Drosophila melanogaster. Nonetheless, chromosomal synteny generally maintained among all three insects, although conservation...
Leptospira species colonize a significant proportion of rodent populations worldwide and produce life-threatening infections in accidental hosts, including humans. Complete genome sequencing interrogans serovar Copenhageni comparative analysis with the available Lai reveal that despite overall genetic similarity there are structural differences, large chromosomal inversion extensive variation number distribution insertion sequence elements. Genome elucidates many novel aspects leptospiral...
The down-regulation of the tumor-suppressor gene RASSF1A has been shown to increase cell proliferation in several tumors. expression is regulated through epigenetic events involving polycomb repressive complex 2 (PRC2); however, molecular mechanisms modulating recruitment this modifier RASSF1 locus remain largely unknown. Here, we identify and characterize ANRASSF1, an endogenous unspliced long noncoding RNA (lncRNA) that transcribed from opposite strand on lines tissues binds PRC2. ANRASSF1...
Abstract Malignant glioma is a severe type of brain tumor with poor prognosis and few options for therapy. The main chemotherapy protocol this based on temozolomide (TMZ), albeit limited success. Cisplatin widely used to treat several types and, in association TMZ, also recurrent glioma. However, mechanisms cellular resistance cisplatin restrict therapy efficiency. In that sense, enhanced DNA repair, high glutathione levels functional p53 have critical role resistance. work, we explored...
Cancer is a leading cause of death worldwide, and while great advances have been made particularly in chemotherapy, many types cancer still present dismal prognosis. In the case glioma, temozolomide (TMZ) main option for treatment, but it has limited success due to drug resistance. While this resistance usually associated DNA repair mechanisms, work we demonstrate that oxidative stress plays an important role. We showed upon TMZ treatment there induction nuclear factor erythroid 2-related 2...
Most of the studies on air pollution focus emissions from fossil fuel burning in urban centers. However, approximately half world's population is exposed to caused by biomass emissions. In Brazilian Amazon population, over 10 million people are directly high levels pollutants resulting deforestation and agricultural fires. This work first study present an integrated view effects inhalable particles burning. Exposing human lung cells particulate matter smaller than µm (PM
Lung cancer patients face a dismal prognosis mainly due to the low efficacy of current available treatments. Cisplatin is first-line chemotherapy treatment for those patients, however, resistance this drug common and yet not fully understood phenomenon. Aiming shed new light into puzzle, we used established normal malignant lung cell lines displaying different sensitivity towards cisplatin treatment. We observed negative correlation between viability DNA damage induction upon Interestingly,...
Chaperone-mediated autophagy (CMA), a selective form of protein lysosomal degradation, is maximally activated in stress situations to ensure maintenance cellular homeostasis. CMA activity decreases with age and several human chronic disorders, but contrast, most cancer cells, upregulated required for tumor growth. However, the role malignant transformation remains unknown. In this study, we demonstrate that inhibition fibroblasts augments efficiency MYC/c-Myc-driven transformation. blockage...
Air pollution represents a considerable threat to health worldwide. The São Paulo Metropolitan area, in Brazil, has unique composition of atmospheric pollutants with population nearly 20 million people and 9 passenger cars. It is long known that exposure particulate matter less than 2.5 µm (PM2.5) can cause various effects such as DNA damage. One the most versatile defense mechanisms against accumulation damage nucleotide excision repair (NER), which includes XPC protein. However, by NER...
Abstract Xeroderma pigmentosum (XP) is a genetic disorder caused by mutations in genes of the Nucleotide Excision Repair (NER) pathway (groups A-G) or Translesion Synthesis DNA polymerase η (V). XP associated with an increased skin cancer risk, reaching, for some groups, several thousand-fold compared to general population. Here, we analyze 38 genomes from five groups. We find that activity NER determines heterogeneity mutation rates across and transcription-coupled extends beyond gene...
The genome sequence of Leifsonia xyli subsp. xyli, which causes ratoon stunting disease and affects sugarcane worldwide, was determined. single circular chromosome CTCB07 2.6 Mb in length with a GC content 68% 2,044 predicted open reading frames. analysis also revealed 307 pseudogenes, is more than any bacterial plant pathogen sequenced to date. Many these if functional, would likely be involved the degradation heteropolysaccharides, uptake free sugars, synthesis amino acids. Although L. has...