A5066555332- Air Quality and Health Impacts
- Energy and Environment Impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Climate Change and Health Impacts
- Respiratory Support and Mechanisms
- Microplastics and Plastic Pollution
- Neonatal Respiratory Health Research
- Heme Oxygenase-1 and Carbon Monoxide
- Cannabis and Cannabinoid Research
- Immune Response and Inflammation
- Coffee research and impacts
- Environmental and Sediment Control
- Pleural and Pulmonary Diseases
- Prenatal Substance Exposure Effects
- Metal complexes synthesis and properties
- Toxic Organic Pollutants Impact
- Youth, Drugs, and Violence
- GABA and Rice Research
- Carcinogens and Genotoxicity Assessment
- Synthesis and biological activity
- Municipal Solid Waste Management
- Birth, Development, and Health
- Homelessness and Social Issues
- Infection Control and Ventilation
- Recycling and Waste Management Techniques
Universidade de São Paulo
2015-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2020-2023
Microplastic (MP) pollution is an emerging environmental and health concern. While MPs have been detected in various human tissues, their presence the brain has not documented, raising important questions about potential neurotoxic effects mechanisms by which might reach tissues.
Air pollution represents a considerable threat to health worldwide. The São Paulo Metropolitan area, in Brazil, has unique composition of atmospheric pollutants with population nearly 20 million people and 9 passenger cars. It is long known that exposure particulate matter less than 2.5 µm (PM2.5) can cause various effects such as DNA damage. One the most versatile defense mechanisms against accumulation damage nucleotide excision repair (NER), which includes XPC protein. However, by NER...
Acute respiratory distress syndrome (ARDS) has a high mortality rate of 35-46% depending on its severity. Animal models are crucial to better understand the pathophysiology diseases, including ARDS. This study presents feasible animal model acute lung injury (ALI) using nebulized lipopolysaccharide (LPS) in non-invasive approach, focusing short and long-term effects.Mice received LPS or vehicle only (control group). Blood, BALF tissue were collected 24 hours (LPS 24h) 5 weeks 5w) after...
Abstract Background Lung fibrosis is a major concern in severe COVID-19 patients undergoing mechanical ventilation (MV). frequency post-COVID syndrome highly variable and even if the risk proportionally small, many could be affected. However, there still no data on lung extracellular matrix (ECM) composition whether it different from other aetiologies of ARDS. Methods We have quantified ECM elements TGF-β expression tissue 28 fatal cases compared to 27 that died causes ARDS, divided...
Abstract Evidence regarding the impact of air pollution on acute respiratory distress syndrome (ARDS) is limited, and most studies focus ARDS onset. Our study aimed to evaluate whether exposure fine particulate matter interferes with lung recovery remodeling in a murine model injury. Forty-eight mice received nebulized LPS or vehicle (controls). Blood, BALF, lungs spleen were collected after 5 weeks either PM 2.5 (PM + group) filtered (control LPS5w groups). Inflammatory cells cytokines...
Introdução: Gestantes em situação de rua enfrentam um desafio global com consequências negativas para mães e filhos, incluindo gravidezes não planejadas, exploração sexual, complicações na saúde repro
Fine particulate matter (PM2.5) is a complex mixture of components with diverse chemical and physical characteristics associated increased respiratory cardiovascular diseases mortality. Our study aimed to investigate the effects exposure concentrated PM2.5 on LPS-induced lung injury onset. BALB/c male mice were exposed either filtered air or ambient fine in an particle concentrator for 5 weeks. Then, acute was induced nebulized LPS. The animals euthanized 24 h after nebulization LPS saline....
Pulmonary fibrosis is a sequela of ARDS/prolonged ventilation, including severe COVID-19 (COV). There no data on the extracellular matrix (ECM) composition lung remodeling in COV compared to other causes ARDS. We quantified ECM elements by IHC tissues 28 fatal and 27 non-COV cases assessed influence sex, age, mechanical ventilation length (MVL), PaO2/FiO2 ratio values. Lung RNA from 12 divided according MVL: <7 days (L7) (n=5) or ≥7 (H7) (n=7), 4 controls were used for transcriptomics....
Knowing lung structure during aging is important to understand the physiology of senile process and related pathologies, such as COPD. There are scarce pathological data in humans. <b>Aim:</b> To assess, using stereology, volume its compartments adults elderly human lungs. <b>Methods:</b> Ten autopsy right lungs from non-smokers, without pathology were obtained after ethical approval. Lungs tracheally inflated with fixative under constant pressure 20mmHg. Subsequently, lobes separated, total...