A5044617887- Trypanosoma species research and implications
- Galectins and Cancer Biology
- COVID-19 Clinical Research Studies
- Research on Leishmaniasis Studies
- Long-Term Effects of COVID-19
- Cancer-related molecular mechanisms research
- Biomarkers in Disease Mechanisms
- MicroRNA in disease regulation
- Animal Genetics and Reproduction
- Respiratory Support and Mechanisms
- Environmental Sustainability and Education
- SARS-CoV-2 and COVID-19 Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Circular RNAs in diseases
- Education and Digital Technologies
- Protease and Inhibitor Mechanisms
- Ocean Acidification Effects and Responses
- Physiological and biochemical adaptations
- Immune responses and vaccinations
- interferon and immune responses
- Peroxisome Proliferator-Activated Receptors
- Chemokine receptors and signaling
- Electric Motor Design and Analysis
- Legume Nitrogen Fixing Symbiosis
- Science and Education Research
Universidade de São Paulo
2008-2023
Universidade Federal de São Paulo
2019
Universidade de Ribeirão Preto
2014
Universidade Federal de São Carlos
2008
Abstract Background Ralstonia solanacearum is the causal agent of bacterial wilt, a devastating plant disease responsible for serious economic losses especially on potato, tomato, and other solanaceous species in temperate countries. In R. , gene expression analysis has been key to unravel many virulence determinants as well their regulatory networks. However, most these assays have performed using either bacteria grown minimal medium or planta after symptom onset, which occurs at late...
The retina is a notable tissue with high metabolic needs which relies on specialized vascular networks to protect the neural while maintaining constant supplies of oxygen, nutrients, and dietary essential fatty acids. Here we analyzed lipidome mouse under healthy pathological angiogenesis using oxygen-induced retinopathy model. By matching lipid profiles changes in mRNA transcriptome, identified signature showing that leads intense remodeling favoring pathways for neutral synthesis,...
Abstract Background Lung fibrosis is a major concern in severe COVID-19 patients undergoing mechanical ventilation (MV). frequency post-COVID syndrome highly variable and even if the risk proportionally small, many could be affected. However, there still no data on lung extracellular matrix (ECM) composition whether it different from other aetiologies of ARDS. Methods We have quantified ECM elements TGF-β expression tissue 28 fatal cases compared to 27 that died causes ARDS, divided...
The specific genes and molecules that drive physiological angiogenesis differ from those involved in pathological angiogenesis, suggesting distinct mechanisms for these seemingly related processes. Unveiling pathways preferentially associated with pathologic is key to understanding its mechanisms, thereby facilitating development of novel approaches managing angiogenesis-dependent diseases. To better understand different processes, we elucidated the transcriptome mouse retina well-accepted...
Large-scale mapping of antigens and epitopes is pivotal for developing immunotherapies but challenging, especially eukaryotic pathogens, owing to their large genomes. Here, we developed an integrated platform genome phage display (gPhage) show that unbiased libraries the parasite Trypanosoma cruzi enable identification thousands recognized by serum samples from patients with Chagas disease. Because most these are hypothetical proteins, gPhage provides evidence expression during infection. We...
Idiopathic pulmonary artery hypertension (IPAH), chronic thromboembolic (CTEPH), and acute embolism (APTE) are life-threatening cardiopulmonary diseases without specific surgical or medical treatment. Although APTE, CTEPH IPAH different vascular in terms of clinical presentation, prevalence, pathophysiology prognosis, the identification their circulating microRNA (miRNAs) might help recognizing differences outcome evolution forms. The aim this study was to describe CTEPH, IPAH-associated...
There have been significant improvements in Chagas disease therapy and it is now widely accepted that most patients with chronic might benefit from therapy. However, there are challenges to monitor drug efficacy cure for these patients, which important impediments current future therapies. Trypanosoma cruzi-PCR highly variable while IgG seroconversion takes decades yielding results depending on the antigen(s) used assay.
O presente artigo científico irá abordar sobre a educação não formal em espaços fora da Universidade, analisando à exposição “Simbolos Sagrados das Religiões: Conhecer para respeitar e conviver paz” ocorrida 20/10/2024, na Praça República (ao lado do teatro Waldemar Henrique), Belém Pará. A foi promovida pela Universidade Estado Pará - UEPA, através Grupo de Estudos Ensino Religioso Amazônia GEPERA. Com participação graduandos licenciatura Ciências Religião, bem como mestrandos doutorandos...
The histiotrophic nutrition by the endometrial glands and materno-fetal interface in cloned cattle placenta were analyzed order to investigate iron transfer. Placentomes intercaruncular region samples recovered at term Caesarean delivery from 14 10 controls, fixed 4% paraformaldehyde 10% formaldehyde PBS, processed stained for light microscopy (hematoxylin-eosin, picrosirius, Masson's trichrome), histochemistry [Perls, acid phosphatase periodic Schiff (PAS) reactions], immunohistochemistry...
Pulmonary fibrosis is a sequela of ARDS/prolonged ventilation, including severe COVID-19 (COV). There no data on the extracellular matrix (ECM) composition lung remodeling in COV compared to other causes ARDS. We quantified ECM elements by IHC tissues 28 fatal and 27 non-COV cases assessed influence sex, age, mechanical ventilation length (MVL), PaO2/FiO2 ratio values. Lung RNA from 12 divided according MVL: <7 days (L7) (n=5) or ≥7 (H7) (n=7), 4 controls were used for transcriptomics....
O presente trabalho apresenta um m´etodo para reduc¸ ˜ao das ondulac¸ ˜oes no torque eletromagn´etico em motores brushless DC (BLDC) atrav´es do emprego de uma extens˜ao da transformac¸ dq cl´assica, tratada aqui por estendida ou dqx. mostra modelo vetorial m´aquinas s´ıncronas com ´ım˜a permanente na superf´ıcie rotor (MSIPSR) e fluxo entreferro n˜ao senoidal, aplicac¸ ao m´aquina. No trabalho, mostra-se que a ´e aplic´avel somente perfil trapezoidal forc¸a contra-eletromotriz, mas qualquer...
<b>Background:</b> The key impact of SARS-CoV-2 is its ability to cause a life-threatening infection in the lung. <b>Aims:</b> Using spatially resolved multiplex imaging present study decodes immunopathological complexity severe COVID-19. <b>Methods:</b> Autopsy lung tissue from 18 COVID-19 patients was used map immune and structural cells acute/exudative, intermediate advanced diffuse alveolar damage (DAD) through immunohistochemistry spatial statistical analyses. Cytokine profiling, viral,...
SARS-CoV2 infection induces a complex interaction between virus and host immune system, activating multiple inflammatory pathways leading to hyperinflammation, diffuse alveolar damage (DAD), ARDS, multiorgan failure. We aimed correlate the quantification of viral load, cells cytokines in lung tissue fatal COVID-19. assessed by multiplex immunohistochemistry, Luminex xMAP Assay load real time PCR autopsy 18 COVID-19 patients. Correlations were considered statistically significant if...
Severe COVID-19 induces DAD, a condition with temporal-spatial heterogeneity. We determined the differentially expressed genes (DEGs) in histological patterns of DAD. Twelve fatal cases were classified acute DAD (n=5) and intermediate/advanced (IA) (n=7). Autopsy lung RNA was extracted from 4 control cases. sequencing performed on Illumina NovaSeq 6000. Enrichment analysis clusterProfiler using Genome-wide annotation for Human R package. GO terms KEGG pathways considered enriched if adjusted...