A5046728435- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Protease and Inhibitor Mechanisms
- Biochemical and Structural Characterization
- Chemokine receptors and signaling
- Angiogenesis and VEGF in Cancer
- Cancer, Lipids, and Metabolism
- Advanced Biosensing Techniques and Applications
- interferon and immune responses
- Peroxisome Proliferator-Activated Receptors
Universidade de São Paulo
2019-2024
The retina is a notable tissue with high metabolic needs which relies on specialized vascular networks to protect the neural while maintaining constant supplies of oxygen, nutrients, and dietary essential fatty acids. Here we analyzed lipidome mouse under healthy pathological angiogenesis using oxygen-induced retinopathy model. By matching lipid profiles changes in mRNA transcriptome, identified signature showing that leads intense remodeling favoring pathways for neutral synthesis,...
The specific genes and molecules that drive physiological angiogenesis differ from those involved in pathological angiogenesis, suggesting distinct mechanisms for these seemingly related processes. Unveiling pathways preferentially associated with pathologic is key to understanding its mechanisms, thereby facilitating development of novel approaches managing angiogenesis-dependent diseases. To better understand different processes, we elucidated the transcriptome mouse retina well-accepted...