Juliana Machado-Rugolo
A5048212818- Lung Cancer Treatments and Mutations
- COVID-19 Clinical Research Studies
- Lung Cancer Research Studies
- COVID-19 and healthcare impacts
- Health Systems, Economic Evaluations, Quality of Life
- Pulmonary Hypertension Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Vitamin D Research Studies
- Parathyroid Disorders and Treatments
- Long-Term Effects of COVID-19
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Sepsis Diagnosis and Treatment
- Dialysis and Renal Disease Management
- COVID-19 and Mental Health
- COVID-19 Impact on Reproduction
- Cancer Genomics and Diagnostics
- Machine Learning in Healthcare
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Neuroendocrine Tumor Research Advances
- COVID-19 diagnosis using AI
- Public Health in Brazil
- Delphi Technique in Research
Universidade Estadual Paulista (Unesp)
2016-2025
Universidade de São Paulo
2017-2025
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2021-2024
Hospital Nossa Senhora da Conceição
2022-2024
Hospital das Clínicas da Universidade Federal de Minas Gerais
2022-2023
Genomic (Brazil)
2021
Genomics (United Kingdom)
2020
Hospital de Clínicas de Porto Alegre
2018
Laboratório Bacchi
2013
To describe the clinical characteristics, laboratory results, imaging findings, and in-hospital outcomes of COVID-19 patients admitted to Brazilian hospitals.A cohort study laboratory-confirmed who were hospitalized from March 2020 September in 25 hospitals. Data collected medical records using Research Electronic Capture (REDCap) tools. A multivariate Poisson regression model was used assess risk factors for mortality.For a total 2,054 (52.6% male; median age 58 years), mortality 22.0%;...
Abstract Background Although dementia has emerged as an important risk factor for severe SARS-CoV-2 infection, results on COVID-19-related complications and mortality are not consistent. We examined the clinical presentations outcomes of COVID-19 in a multicentre cohort in-hospital patients, comparing those with without dementia. Methods This retrospective observational study comprises laboratory-confirmed patients aged ≥ 60 years admitted to 38 hospitals from 19 cities Brazil. Data were...
Abstract The majority of early prediction scores and methods to predict COVID-19 mortality are bound by methodological flaws technological limitations (e.g., the use a single model). Our aim is provide thorough comparative study that tackles those issues, considering multiple techniques build models, including modern machine learning (neural) algorithms traditional statistical techniques, as well meta-learning (ensemble) approaches. This used dataset from multicenter cohort 10,897 adult...
Abstract Background Acute kidney injury (AKI) is frequently associated with COVID-19, and the need for replacement therapy (KRT) considered an indicator of disease severity. This study aimed to develop a prognostic score predicting KRT in hospitalised COVID-19 patients, assess incidence AKI requirement. Methods part multicentre cohort, Brazilian Registry. A total 5212 adult patients were included between March/2020 September/2020. Variable selection was performed using generalised additive...
Brazil has the world's largest public organ transplant program, which was severely affected by COVID-19 pandemic. The primary aim of study to evaluate differences in solid transplants and rejection episodes during pandemic compared five years before country.A seven-year database built downloading data from DATASUS server. period defined as March 2020 December 2021. pre-pandemic January 2015 2020.During pandemic, number decreased 19.3% 22.6% 2021 2019. We found a decrease for each evaluated...
Cutaneous melanoma in young patients is rare with increasing incidence. It not clear whether the etiology and clinical outcome are similar to cutaneous elderly. Mutations BRAF gene melanoma, general, range frequency from 20% 80%; however, status significance of mutations population have been evaluated. We investigated 132 cases primary aged between 18 30 years emphasis on characteristics, pathologic features, molecular evaluation mutation (BRAFV600E). was predominantly seen female...
Context.— Identification of gene mutations that are indicative epithelial-mesenchymal transition and a noninflammatory immune phenotype may be important for predicting response to checkpoint inhibitors. Objective.— To evaluate the utility multiplex immunofluorescence profiling determine relationships among tumor genomic profiles clinical outcomes patients with nonmetastatic non–small cell lung cancer. Design.— Tissue microarrays containing 164 primary specimens from stages I IIIA carcinoma...
It is not clear whether previous thyroid diseases influence the course and outcomes of COVID-19.The study a part multicentric cohort patients with confirmed COVID-19 diagnosis from 37 hospitals. Matching for age, sex, number comorbidities, hospital was performed paired analysis.Of 7,762 COVID-19, 526 had previously diagnosed hypothyroidism were matched controls. The median age 70 years, 68.3% females. prevalence comorbidities similar, except coronary chronic kidney that higher in group...
Idiopathic pulmonary artery hypertension (IPAH), chronic thromboembolic (CTEPH), and acute embolism (APTE) are life-threatening cardiopulmonary diseases without specific surgical or medical treatment. Although APTE, CTEPH IPAH different vascular in terms of clinical presentation, prevalence, pathophysiology prognosis, the identification their circulating microRNA (miRNAs) might help recognizing differences outcome evolution forms. The aim this study was to describe CTEPH, IPAH-associated...
Studies that use medical records are often impeded due to the information presented in narrative fields. However, recent studies have used artificial intelligence extract and process secondary health data from electronic records. The aim of this study was develop a neural network uses unstructured capture regarding symptoms, diagnoses, medications, conditions, exams, treatment. Data 30,000 patients hospitalized Clinical Hospital Botucatu Medical School (HCFMB), São Paulo, Brazil, were...
Typical carcinoids (TC), atypical (AC), large cell neuroendocrine carcinomas (LCNEC), and small lung (SCLC) encompass a bimodal spectrum of metastatic tumors with morphological, histological histogenesis differences, The hierarchical structure reveals high cohesiveness between neoplastic cells by mechanical desmosomes barrier assembly in carcinoid LCNEC, while SCLC does not present an organoid arrangement morphology, the are less cohesive. However, molecular mechanisms that lead to PNENs...
Several studies have reported the pathophysiologic and molecular mechanisms responsible for pulmonary arterial hypertension (PAH). However, in situ evidence of collagen V (Col V) interleukin-17 (IL-17)/interleukin-6 (IL-6) activation PAH has not been fully elucidated. We analyzed effects I I), Col V, IL-6, IL-17 on vascular remodeling hemodynamics its possible action monocrotaline (MCT)-induced PAH. Twenty male Wistar rats were randomly divided into two groups. In group, animals received MCT...
The COVID-19 pandemic caused unprecedented pressure over health care systems worldwide. Hospital-level data that may influence the prognosis in patients still needs to be better investigated. Therefore, this study analyzed regional socioeconomic, hospital, and intensive units (ICU) characteristics associated with in-hospital mortality admitted Brazilian institutions. This multicenter retrospective cohort is part of Registry. We enrolled ≥ 18 years old laboratory-confirmed participating...
Intratumoral similarities and differences between large-cell neuroendocrine carcinomas (LCNECs) small-cell lung (SCLCs) are determined partially by the Notch signaling pathway, which controls switch from to slight/non-neuroendocrine cell fate. LCNECs divided into two subgroups according genomic alterations: type I exhibit a profile characterized achaete‐scute homolog 1 (ASCL1)high/delta-like protein 3 (DLL3)high/NOTCHlow II show pattern ASCL1low/DLL3low/NOTCHhigh. Here, we used...
Pleckstrin homology domain family A (PHLDA) genes play important roles in cancer cellular processes, including inhibiting Akt activation, repressing growth factor signaling, the negative feedback of EGFR/ErbB2 signaling cells, and inducing apoptosis. However, prognostic significance PHLDA non-small cell lung (NSCLC) malignant pleural mesothelioma (MM) remains unclear. The present study investigates associations between expression patterns their value adenocarcinoma (LUAD) MM.We analyzed...
Although non-small cell lung cancer (NSCLC) remains a deadly disease, new predictive biomarkers have emerged to assist in managing the of which one most promising is programmed death-ligand 1 (PD-L1). Each, PD-L1 variant seem modulate function immune checkpoints differently and affect response adjuvant treatment outcome NSCLC patients. We thus investigated influence these genetic variations genetically admixed tissue samples, correlated values with clinicopathological characteristics,...
Non-small cell lung carcinoma (NSCLC) is a complex cancer biome composed of malignant cells embedded in sophisticated tumor microenvironment (TME) combined with different initiating types, including immune and cancer-associated fibroblasts (CAFs), extracellular matrix (ECM) proteins. However, little known about these tumors' immune-matricellular relationship as functional mechanical barriers. This study investigated 120 patients NSCLC to describe the phenotypes their TME cells....
Lung cancer still represents a global health problem, being the main type of tumor responsible for deaths. In this context, microenvironment, and extracellular matrix (ECM) pose as extremely relevant. Thus, study aimed to explore prognostic value epithelial-to-mesenchymal transition (EMT), Wnt signaling, ECM proteins expression in patients with non-small-cell lung carcinoma (NSCLC) clinical stages I-IIIA. For that, we used 120 tissue sections from evaluated immunohistochemical,...
Abnormal long non-coding RNAs (lncRNAs) expression has been documented to have oncogene or tumor suppressor functions in the development and progression of cancer, emerging as promising independent biomarkers for molecular cancer stratification patients’ prognosis. Examining relationship between lncRNAs survival rates malignancies creates new scenarios precision medicine targeted therapy. Breast (BRCA) is a heterogeneous malignancy. Despite advances its classification, there are still gaps...