A5038989449- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Sarcoma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- HER2/EGFR in Cancer Research
- Chronic Lymphocytic Leukemia Research
- Gastrointestinal Tumor Research and Treatment
- Vascular Tumors and Angiosarcomas
- T-cell and Retrovirus Studies
- Cancer and Skin Lesions
- Soft tissue tumor case studies
- Histiocytic Disorders and Treatments
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Tumors and Oncological Cases
- Ovarian cancer diagnosis and treatment
- Cancer-related Molecular Pathways
- Cutaneous lymphoproliferative disorders research
- CNS Lymphoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
Laboratório Bacchi
2016-2025
Biopticka Laborator (Czechia)
2025
University Hospital Foundation
2024
Universidade Estadual Paulista (Unesp)
2000-2023
Universidade de São Paulo
1999-2023
Universidade do Porto
2021
University of Ljubljana
2017
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2011-2015
Escola Bahiana de Medicina e Saúde Pública
2014
Oakland University
2013
Hepatitis C virus (HCV) infection causes both acute and chronic liver disease is also associated with mixed cryoglobulinemia. Whether HCV renal disease, as the hepatitis B virus, not known. We describe clinical, pathologic, virologic, immunologic features of eight patients who were referred to nephrologists for glomerulonephritis. Four treated interferon alfa.
CDX2 is a recently cloned homeobox gene that encodes an intestine-specific transcription factor, expressed in the nuclei of epithelial cells throughout intestine, from duodenum to rectum. While expression protein primary and metastatic colorectal carcinomas has been previously documented, neither sensitivity nor specificity expression, as determined by immunohistochemistry, for adenocarcinoma determined. We performed immunohistochemical survey 476 tumors with monoclonal antibody, CDX2–88,...
Breast implant-associated anaplastic large-cell lymphoma (ALCL) is a recently described clinicopathologic entity that usually presents as an effusion-associated fibrous capsule surrounding implant. Less frequently, it mass. The natural history of this disease and long-term outcomes are unknown.We reviewed the literature for all published cases breast ALCL from 1997 to December 2012 contacted corresponding authors update clinical follow-up.The median overall survival (OS) 60 patients was 12...
Immunosuppression therapy with cyclosporine is often hampered by significant interindividual variability in the metabolic clearance of drug. It has been suggested that much due to differences cytochrome P450 3A4 (CYP3A4) content liver and intestinal mucosa. A study was conducted transplant recipients characterize hepatic CYP3A during first 10 days after surgery. The formation 1'-hydroxymidazolam (1'-OH MDZ) followed plasma i.v. midazolam (MDZ) administration 21 multiple-organ donors donor...
We report a prospective clinical and virological study of 18 patients undergoing orthotopic liver transplantation, selected because hepatitis C virus (HCV) RNA positivity before transplantation. Nine the (50%) developed chronic active (CAH) in allografts during first year posttransplantation; was observed between 6 25 weeks posttransplantation. HCV viremia measured for all transplantation on posttransplantation days 3, 7, 14, months 1, 6, 12, 24 to 41, by quantitative competitive polymerase...
Carcinoma of the collecting ducts Bellini and renal medullary carcinoma are rare aggressive neoplasms putative distal nephron origin. First described in 1949, case reports review articles constitute a major source information on duct carcinoma, whereas Davis colleagues pediatric tumor registry have contributed seminal works carcinoma. Here we present detailed study (n=39) (n=13), characterizing these analyzing their interrelationship. Both exhibited significant similarities, such as...
Extranodal natural killer/T-cell lymphoma, nasal type (NK/TCL) is more prevalent in Asia and some areas of South Central America, but it rarely seen the United States Europe. In this study, a series 122 cases NK/TCL from Brazil was analyzed with respect to clinicopathologic features. Clinical characteristics geographic distribution were evaluated 97 nasal/nasopharyngeal region 23 extranasal sites including 6 nodal cases. staging follow-up information available subset 21 patients. All...
MYC translocations are a defining feature of Burkitt lymphoma and group diffuse large B-cell (DLBCL) with inferior outcome. However, the clinical relevance gene rearrangement its relationship protein expression has not been well characterized in lymphomas. Tissue microarrays containing 1214 lymphomas were successfully evaluated by immunohistochemistry using anti-MYC clone Y69 dual-color break-apart fluorescence situ hybridization probe to detect rearrangements. Aggressive including DLBCL...
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of gastrointestinal tract. Discovered on GIST-1 (DOG1) a recently described protein expressed in GISTs irrespective mutation status. The aim this study was to investigate immunohistochemical expression DOG1 using 2 different monoclonal antibodies (DOG1.1 and commercially available K9 antibody) 668 GIST cases compare results with KIT. KIT also were studied human normal tissues several nonmesenchymal tumors other...
We report 2 primary renal sarcomas demonstrating BCOR-CCNB3 gene fusions that have recently been identified in undifferentiated round cell of bone and soft tissue. These neoplasms occurred male children aged 11 12 years, both were cystic as a result entrapment dilatation native tubules. Both cases composed variably cellular bland spindle cells with fine chromatin set myxoid stroma separated by branching capillary vasculature. demonstrated immunoreactivity for BCOR, cyclin D1, TLE1, SATB2 the...
Desmoplastic melanoma (DM) is histologically characterized by a proliferation of spindle melanocytes dispersed in collagenous stroma that can be mistaken for variety neoplasms. The purpose this study was to analyze 40 cases DM with comprehensive panel immunohistochemical markers (KBA.62, p16, Ezrin, WT-1, MITF-1, SOX-10, CD117, SOX-2, nestin, PNL2, p75, MART-1, gp100 and S100p) obtain more complete understanding the potential use these antibodies diagnosis DM. We found all expressed nestin...
Description of some the clinical pathological characteristics neuroendocrine tumors gastroenteropancreatic tract in Brazilian patients. Neuroendocrine arise many organs and share common features. In 2010, World Health Organization published a new classification for using three-tiered system that applies terms tumor Grade 1, 2, carcinoma. The grades are based on their mitotic rate Ki-67 index. Brazil, information is scarce. This study investigated clinicopathological features 773 cases from...
To compare the distribution of intrinsic molecular subtypes breast cancer based on immunohistochemical profile in five major geographic regions Brazil, a country continental dimension, with wide racial variation people. The study was retrospective observational. We classified 5,687 invasive cancers by subtype expression estrogen-receptor (ER), progesterone-receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67 proliferation index. Cases were as luminal A (ER and/or PR...
Refractory celiac disease type II (RCD II), also referred to as “cryptic” enteropathy-associated T-cell lymphoma (EATL) or “intraepithelial lymphoma,” is a rare clonal lymphoproliferative disorder that arises from innate intraepithelial lymphocytes. RCD has poor prognosis and frequently evolves EATL. The pathogenesis of not well understood data regarding the immunophenotypic spectrum this underlying genetic alterations are limited. To gain further biological insights, we performed...
A type of cholangiocarcinoma (CCA) characterized by peculiar histologic patterns and underlying adenofibromatous lesions has been reported in the literature mostly as individual case reports. This study aims to further clarify defining characteristics this spectrum lesions. Clinicopathologic analysis 8 biliary tumors with tubulocystic architecture arising background adenofibroma-type was performed. Three these were also investigated next-generation sequencing a 174 genes panel. The patients...
Laryngeal carcinomas are aggressive neoplasms with controversial association the human papillomavirus (HPV) and Epstein-Barr virus (EBV). So far, impairment of p53 protein function its impact on cellular proliferation has not been studied adequately in these tumors. In this work, molecular biologic techniques were used to assess frequency HPV EBV 110 squamous cell larynx. addition, accumulation Ki-67 antigen expression malignant cells was assessed by immunohistochemical analysis. High-grade...