A5015423699- Sarcoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- Soft tissue tumor case studies
- Neuroendocrine Tumor Research Advances
- CAR-T cell therapy research
- Tumors and Oncological Cases
- Glioma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Pancreatic and Hepatic Oncology Research
- Cardiac tumors and thrombi
- Renal and related cancers
- Hepatocellular Carcinoma Treatment and Prognosis
- Histiocytic Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Testicular diseases and treatments
- Management of metastatic bone disease
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- IgG4-Related and Inflammatory Diseases
- Ovarian cancer diagnosis and treatment
- Urologic and reproductive health conditions
- Gastrointestinal disorders and treatments
- Bone Tumor Diagnosis and Treatments
- Congenital Diaphragmatic Hernia Studies
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2025
Bambino Gesù Children's Hospital
2019-2025
Sapienza University of Rome
2022-2025
University of Cincinnati Medical Center
2023
Cincinnati Children's Hospital Medical Center
2023
University of Padua
2012-2022
Children's Hospital of Pittsburgh
2017-2022
Texas Children's Hospital
2019-2022
Baylor College of Medicine
2019-2022
University of Pittsburgh
2017-2021
To assess the value of chemotherapy and radiotherapy in children with malignant peripheral nerve sheath tumors (MPNSTs) to identify risk factors associated outcome.A total 167 untreated eligible patients enrolled onto Italian German studies between 1975 1998 entered this analysis. Seventeen percent had neurofibromatosis type 1 (NF1). Chemotherapy was administered 74% patients; 38% patients.With a median follow-up 7 years, 5-year overall survival (OS) progression-free (PFS) were 51% 37%,...
Approximately 50% of conventional inflammatory myofibroblastic tumors (IMTs) harbor ALK gene rearrangement and overexpress ALK. Recently, fusions involving other kinases have been implicated in the pathogenesis IMT, including ROS1 1 patient PDGFRB. However, it remains uncertain whether emerging genotypes correlate with clinicopathologic characteristics IMT. In this study, we expand molecular investigation IMT a large cohort different clinical presentations analyze for potential...
Sclerosing rhabdomyosarcoma (ScRMS) and spindle cell (SRMS) have been recently reclassified as a stand-alone pathologic entity, separate from embryonal RMS. Genetically, subset of the congenital cases display NCOA2 gene rearrangements, whereas tumors occurring in older children or adults harbor MYOD1 mutations with without coexisting PIK3CA mutations. Despite these recent advances, significant number lack known genetic alterations. In this study we sought to investigate large group pediatric...
With the advent of next-generation sequencing, an increasing number novel gene fusions and other abnormalities have emerged recently in spectrum EWSR1 -negative small blue round cell tumors (SBRCTs). In this regard, a subset SBRCTs harboring either BCOR ( BCOR-CCNB3 , BCOR-MAML3 ), internal tandem duplications (ITD), or YWHAE-NUTM2B share transcriptional signature including high mRNA expression, as well similar histologic features. Furthermore, such clear sarcoma kidney (CCSK) primitive...
Soft tissue undifferentiated round cell sarcoma (URCS) occurring in infants is a heterogenous group of tumors, often lacking known genetic abnormalities. On the basis t(10;17;14) karyotype pelvic URCS 4-month-old boy showing similar breakpoints with clear kidney (CCSK), we have investigated possibility shared abnormalities CCSK and soft URCS. Most CCSKs are characterized by BCOR exon 16 internal tandem duplications (ITDs), whereas smaller subset shows YWHAE - NUTM2B/E fusions. Because...
Acral chilblain-like lesions are being increasingly reported during COVID-19 pandemic. However, only few patients proved positivity for SARS-CoV-2 infection. The relationship between this skin manifestation and infection has not been clarified yet.To thoroughly characterize a prospective group of with to investigate the possible infection.Following informed consent, underwent (i) clinical evaluation, (ii) RT-PCR serology testing SARS-CoV-2, (iii) digital videocapillaroscopy finger toe...
Liposarcomas typically occur in middle aged to older adults. Altogether, approximately 50 bona fide liposarcomas have been reported children and adolescents, most of which represented myxoid liposarcomas, with a good prognosis. We undertook retrospective study 82 occurring patients below 22 years age. Clinicopathologic follow-up information was obtained. Fluorescence situ hybridization for FUS, EWSR1, CHOP (DDIT3), MDM2 performed 30 cases. The tumors occurred 28 males 54 females (5 y age)...
Ewing sarcoma family tumors (EFTs) of the head and neck are rare may be difficult to diagnose, as they display significant histologic overlap with other more common undifferentiated small blue round cell malignancies. Occasionally, EFTs exhibit overt epithelial differentiation in form diffuse cytokeratin immunoexpression or squamous pearls, resembling so-called adamantinoma-like being challenging distinguish from bona fide carcinomas. Furthermore, presence EWSR1 gene rearrangement correlated...
Aggressive fibromatosis (AF) is a rare tumor of intermediate malignancy that has strong potential for local invasiveness and recurrence. To date, there are no general recommendations the clinical management pediatric AF.The authors retrospectively analyzed 94 patients aged < or =21 years, including 23 who underwent complete surgery (Group I), 42 incomplete with microscopic residual II), 29 either biopsy macroscopically III).The 5-year event-free survival (EFS) overall rates were 44% 99%,...
Infantile fibrosarcomas (IFS) represent a distinct group of soft tissue tumors occurring in patients under 2 years age and most commonly involving the extremities. Most IFS show recurrent ETV6-NTRK3 gene fusions, sensitivity to chemotherapy, an overall favorable clinical outcome. However, outside these well-defined pathologic features, no studies have investigated lacking or with morphology resembling older children. This study was triggered by identification novel SEPT7-BRAF fusion...
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary point, may be published when key planned co-primary or secondary analyses are not yet available. Trial Updates provide an opportunity to disseminate additional results from studies, in JCO elsewhere, for which point has already been reported.The RMS2005 study included two phase III randomized high-risk (HR) and observational low (LR), standard (SR), very...
Hepatoblastoma (HB) is the most frequent childhood liver cancer. Patients with aggressive tumors have limited therapeutic options; therefore, a better understanding of HB pathogenesis needed to improve treatment. HBs very low mutational burden; however, epigenetic alterations are increasingly recognized. We aimed identify regulators consistently dysregulated in and evaluate efficacy their targeting clinically relevant models.We performed comprehensive transcriptomic analysis 180 genes. Data...
Abstract Purpose: Medulloblastoma (MB), the most common childhood malignant brain tumor, has a poor prognosis in about 30% of patients. The current standard care, which includes surgery, radiation, and chemotherapy, is often responsible for cognitive, neurologic, endocrine side effects. We investigated whether chimeric antigen receptor (CAR) T cells directed toward disialoganglioside GD2 can represent potentially more effective treatment with reduced long-term Experimental Design: expression...