A5061528297- Sarcoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Tumors and Oncological Cases
- Childhood Cancer Survivors' Quality of Life
- CAR-T cell therapy research
- Cardiac tumors and thrombi
- Glioma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Neurofibromatosis and Schwannoma Cases
- Testicular diseases and treatments
- Vascular Tumors and Angiosarcomas
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Family Support in Illness
- Rheumatoid Arthritis Research and Therapies
- Neutropenia and Cancer Infections
- Surgical site infection prevention
- Immune Cell Function and Interaction
- Cancer therapeutics and mechanisms
- MicroRNA in disease regulation
- Neuroendocrine Tumor Research Advances
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
Bambino Gesù Children's Hospital
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
Palmetto Hematology Oncology
2024
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2022
Istituto Neurologico Mediterraneo
2016
Boston Children's Hospital
2005-2014
University of Perugia
2013
Azienda Ospedaliera di Perugia
2009-2011
Ospedale Santa Maria
2009-2011
Queen's Medical Centre
2008
Aggressive fibromatosis (AF) is a rare tumor of intermediate malignancy that has strong potential for local invasiveness and recurrence. To date, there are no general recommendations the clinical management pediatric AF.The authors retrospectively analyzed 94 patients aged < or =21 years, including 23 who underwent complete surgery (Group I), 42 incomplete with microscopic residual II), 29 either biopsy macroscopically III).The 5-year event-free survival (EFS) overall rates were 44% 99%,...
Optic pathway gliomas (OPGs) in childhood are associated with neurofibromatosis type 1 (NF1) and since 1958 have been classified anatomically using the Dodge classification (DC). MR scanning permits a more detailed anatomical description than can be by this historical system. A modified (MDC) has applied to MRI scans from cohort of 72 patients (36.1% NF1-positive) 4 centres participating an international clinical trial. The MDC was feasible, applicable original DC. NF1-positive cases...
Pseudomonas aeruginosa is one leading gram-negative organism associated with nosocomial infections. Bacteremia life-threatening in the immunocompromised host. Increasing frequency of multi-drug-resistant (MDRPA) strains concerning. We started a retrospective survey pediatric hematology oncology Italian network. Between 2000 and 2008, 127 patients bacteremia were reported from 12 centers; 31.4% isolates MDRPA. Death within 30 days positive blood culture occurred 19.6% (25/127) total patients;...
BACKGROUND Alveolar rhabdomyosarcoma (aRMS) with lymph node involvement (N1 classification) accounts for up to 10% of all cases RMS. The prognosis is poor, and comparable that distant metastatic disease. In the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG) RMS2005 protocol, patients a histologic diagnosis aRMS/N1 received intensified chemotherapy systematic locoregional treatment. METHODS Patients were enrolled prospectively after primary surgery/biopsy fusion status was...
Purpose: Aneurysmal bone cyst (ABC) is a rare skeletal tumor usually treated with surgery/embolization. We hypothesized that owing to similarities giant cell of (GCTB), denosumab was active also in ABC. Methods: In this observational study, retrospective analysis ABC patients performed. Patients underwent radiologic disease assessment every 3 months. Symptoms and adverse events were noted. Results: Nine identified (6 male, female), median age 17 years (range 14–42 years). Primary sites 6...
Embryonal Rhabdomyosarcoma (RMS) is a pediatric soft-tissue sarcoma derived from myogenic precursors that characterized by good prognosis in patients with localized disease. Conversely, metastatic tumors often relapse, leading to dismal outcome. The histone methyltransferase EZH2 epigenetically suppresses skeletal muscle differentiation repressing the transcription of genes. Moreover, de-regulated expression has been extensively implied human cancers. We have previously shown aberrantly...
This work describes the set-up of a shared platform among laboratories Alleanza Contro il Cancro (ACC) Italian Research Network for identification fusion transcripts in sarcomas by using Next Generation Sequencing (NGS). Different NGS approaches, including anchored multiplex PCR and hybrid capture-based panels, were employed to profile large set different histotypes. The analysis confirmed reliability RNA-based approaches detecting sarcoma-specific rearrangements. Overall, assay proved be...
Background According to retrospective osteosarcoma series, ABCB1/P‐glycoprotein (Pgp) overexpression predicts for poor outcomes. A prospective trial assess a risk‐adapted treatment strategy using mifamurtide in Pgp+ patients was performed. Methods This phase 2, multicenter, uncontrolled including 40 years old or younger with nonmetastatic extremity high‐grade stratified according Pgp expression. All received high‐dose methotrexate, doxorubicin, and cisplatin (MAP) preoperatively. In...
Abstract Background Malignant peripheral nerve sheath tumors (MPNSTs) account for 3–10% of pediatric sarcomas, 50% which occur in neurofibromatosis type 1 (NF1). Sporadic MPNSTs diagnosis may be challenging due to the absence specific markers, apart from immunohistochemical H3K27me3 loss. DNA methylation (DNAm) profiling is a useful tool brain and mesenchymal neoplasms categorization, exhibit DNAm signature. An MPNST-like group has recently been recognized, including with retained mark...
Rhabdomyosarcoma (RMS) is a pediatric soft tissue sarcoma arising from myogenic precursors that have lost their capability to differentiate into skeletal muscle. The polycomb-group protein EZH2 Lys27 histone H3 methyltransferase regulates the balance between cell proliferation and differentiation by epigenetically silencing muscle-specific genes. often over-expressed in several human cancers acting as an oncogene. We previously reported inhibition induces cycle arrest followed of RMS cells...
CWS/RMS-96 was an international multicenter trial with randomization between two therapy arms of the standard four-drug (vincristine, ifosfamide, adriamycin, dactinomycin [VAIA]) versus intensified six-drug regimen (carboplatin, epirubicin, vincristine, dactinomycin, and etoposide [CEVAIE]) for high-risk rhabdomyosarcoma (RMS), extraskeletal Ewing sarcoma (EES), undifferentiated (UDS) in children, adolescents, young adults aiming to improve their survival. Intensified chemotherapy CEVAIE did...
In the pediatric population, BCL6-correpresor gene (BCOR)–upregulated tumors include primitive myxoid mesenchymal tumors/undifferentiated sarcomas (PMMTI/UND), clear cell of kidney (CCSK), and high-grade neuroepithelial (HG-NET). We investigated DNA methylation (DNAm) copy number variation (CNV) profiling in these (N = 34) using an Illumina EPIC BeadChip to better define potential use tools confirm diagnosis predict outcomes. Twenty-seven from 25 patients (age range, 0-10 years), showed...
Abstract Background In certain rare undifferentiated small round cell sarcomas new specific molecular CIC‐DUX4 /other partner, BCOR‐CCNB3 YWHAE fusions, or BCOR‐ITD (internal tandem duplication) were identified. These “ CIC fused ” (CIC‐fused/ ATXN1::NUTM1 ) and BCOR rearranged (BCOR fused/ITD/ soft tissue (STS) are not well described. Methods Multi‐institutional European retrospective analysis of young patients (0–24 years) with CIC‐fused STS. Results Overall, out the 60 selected, fusion...
Abstract Background: Childhood cancer survivors are at increased risk of developing cardiovascular diseases, presenting as the main causes morbidity and mortality within this group. Besides usual primary secondary prevention in combination with screening during follow-up, modifiable lifestyle factors physical activity, nutrition, body weight have not yet gained enough attention regarding potential reduction. Objective: These practical recommendations aim to provide summarised information...
Angiosarcoma (AS) represents a rare and aggressive vascular sarcoma, posing distinct challenges in clinical management compared to other sarcomas. While the current European Society of Medical Oncology (ESMO) practice guidelines for sarcoma treatment are applicable AS, its unique aggressiveness diverse tumor presentations necessitate dedicated detailed recommendations, which currently lacking. Notably, considerations regarding surgical extent, radiation therapy (RT), neoadjuvant/adjuvant...
ABSTRACT Background Several studies have shown that the intensity of treatment in Ewing sarcoma has an impact on outcome. The present trial tested non‐inferiority intensive, shorter, induction chemotherapy (25 weeks total time) compared to standard (37 weeks) non‐metastatic (ES) at onset. Procedure This national, multicenter, parallel, randomized, controlled, open‐label, non‐inferiority, phase III was conducted 14 specialized hospitals Italy. Patients aged 2‐40 years with newly diagnosed...