A5067843548- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Proteoglycans and glycosaminoglycans research
- Metastasis and carcinoma case studies
- Cancer-related molecular mechanisms research
- Dietary Effects on Health
- Fibroblast Growth Factor Research
- Molecular Biology Techniques and Applications
- Gut microbiota and health
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
- Tryptophan and brain disorders
- Genetic factors in colorectal cancer
- Mitochondrial Function and Pathology
- Salivary Gland Disorders and Functions
- Glutathione Transferases and Polymorphisms
- Consumer Attitudes and Food Labeling
- Renal and related cancers
- Diet and metabolism studies
AC Camargo Hospital
2013-2025
Genomic (Brazil)
2013-2014
Hospital São Paulo
2013
University of Pecs
2012
Universidade Estadual Paulista (Unesp)
2009
Wilms tumour (WT) is an embryonal kidney neoplasia for which very few driver genes have been identified. Here we identify DROSHA mutations in 12% of WT samples (26/222) using whole-exome sequencing and targeted 10 microRNA (miRNA)-processing genes. A recurrent mutation (E1147K) affecting a metal-binding residue the RNase IIIb domain detected 81% DROSHA-mutated tumours. In addition, non-recurrent other this pathway (DGCR8, DICER1, XPO5 TARBP2). By assessing miRNA expression pattern...
Germline mutations in BRCA1, BRCA2 and TP53 genes have been identified as one of the most important disease-causing issues young breast cancer patients worldwide. The specific defective biological processes that trigger germline mutation-associated -negative tumors remain unclear. To delineate an initial portrait Brazilian early-onset cancer, we performed investigation combining both tumor analysis. screening BRCA2, CHEK2 (c.1100delC) was 54 unrelated <35 y; their were investigated with...
Abstract Nutraceutical interventions supporting microbiota and eliciting clinical improvements in metabolic diseases have grown significantly. Chronic stress, gut dysbiosis, metainflammation emerged as key factors intertwined with sleep disorders, consequently exacerbating the decline quality of life. This study aimed to assess effects two nutraceutical formulations containing prebiotics (fructooligosaccharides (FOS), galactooligosaccharides (GOS), yeast β-glucans), minerals (Mg, Se, Zn),...
ABSTRACT This study explores the effects of a nutraceutical blend with prebiotics, β‐glucans, essential minerals, and silymarin on gut microbiota, inflammation, sleep quality in obesity through microbiota reshaping metabolic improvements over 90 days. A double‐blind, randomized trial was conducted 77 participants divided into two groups receiving either standard (NSupple) or silymarin‐enriched (NSupple_ Silybum ). Fecal plasma samples were collected at baseline post‐supplementation for...
Head and neck squamous cell carcinoma (HNSCC) is associated with environmental factors, especially tobacco alcohol consumption. Most of the carcinogens present in smoke are converted into DNA-reactive metabolites by cytochrome P450 (CYPs) enzymes detoxification these substances performed glutathione S-transferases (GSTs). It has been suggested that genetic alterations, such as polymorphisms, play an important role tumorigenesis HNSCC progression. The aim this study was to investigate CYP1A1,...
A critical issue in defining protocols for biobanking practices is the preservation of total RNA assessing whole transcriptome and ensuring that it can be utilized clinically oriented studies. Storage conditions, such as temperature length time tissues purified stay frozen, may directly impact preservation. In this study, we evaluated a) quality (as measured by Integrity Number) from head neck tumor stored at −140°C distinct intervals up to 7 years, b) their respective RNAs 4 years −80°C...
The search for integrative and natural therapies that favor homeostasis to boost sleep diet quality took place young adult populations as a non-pharmacological strategy long-term good of life. Thus, the present pilot study aims investigate effects 90-day consumption nutraceutical composition on neuro-immune-endocrine axis, providing better health improvement.
Stress, unhealthy lifestyle, and sleep disturbance worsen cognitive function in mood disorders, prompting a rise the development of integrative health approaches. The recent investigations gut–brain axis field highlight strong interplay among microbiota, inflammation, mental health. Thus, this study aimed to investigate new nutraceutical formulation comprising prebiotics, minerals, silymarin’s impact on mood, quality. evaluated LL1 + silymarin capsule supplementation over 180 days overweight...
Typical carcinoids (TC), atypical (AC), large cell neuroendocrine carcinomas (LCNEC), and small lung (SCLC) encompass a bimodal spectrum of metastatic tumors with morphological, histological histogenesis differences, The hierarchical structure reveals high cohesiveness between neoplastic cells by mechanical desmosomes barrier assembly in carcinoid LCNEC, while SCLC does not present an organoid arrangement morphology, the are less cohesive. However, molecular mechanisms that lead to PNENs...
The influence of genetic factors may contribute to the poor prognosis breast cancer (BC) at a very young age. However BRCA1/2 mutations could not explain majority cases arising in these patients. MicroRNAs (miRs) have been implicated biological processes associated with BC. Therefore, we investigated differences miRs expression between tumors from patients (≤35 years) sporadic or familial history and non-carriers mutations. Thirty-six Brazilian were divided into 2 groups: (NF-BC) (F-BC)....
Intratumoral similarities and differences between large-cell neuroendocrine carcinomas (LCNECs) small-cell lung (SCLCs) are determined partially by the Notch signaling pathway, which controls switch from to slight/non-neuroendocrine cell fate. LCNECs divided into two subgroups according genomic alterations: type I exhibit a profile characterized achaete‐scute homolog 1 (ASCL1)high/delta-like protein 3 (DLL3)high/NOTCHlow II show pattern ASCL1low/DLL3low/NOTCHhigh. Here, we used...
TP53 mutations are frequent in non-small cell lung cancer (NSCLC) and have been associated with poor outcome. The prognostic predictive relevance of EGFR/TP53 co-mutations NSCLC is controversial. We analyzed tissue specimens from 70 patients using next-generation sequencing to determine EGFR status the association between these baseline patient tumor characteristics, adjuvant treatments, relapse, progression-free (PFS) overall survival (OS) after surgical resection. found mutation 32.9% (20%...
Abstract The control of pre-analytical-factors in human biospecimens collected for health research is currently required. Only two previous reports using post-mortem brain samples have tried to address the impact cold-ischemia on tissue pH. Here we report pH variations according time (third-order polynomial model) mice liver, kidney and lung samples. Tissue alkalosis may be an underlying mechanism gene expression changes. Therefore, tissue-pH regulation after organ removal minimize biological stress
Abstract Background: Recurrence and metastasis are responsible for 90% of deaths patients with lung cancer. Adenocarcinomas (ADc) primarily invade blood vessels distant metastasis, whereas squamous cell carcinoma (SqCC) involves the mediastinal lymph nodes. Neuroendocrine carcinomas low grade (typical atypical carcinoid) indolent, while high-grade NE (large-cell small-cell carcinomas) metastasize rapidly. Biomarkers invasiveness in still cannot be definitely determined. Epithelial to...
Pulmonary neuroendocrine neoplasms (PNENs) are currently classified into four major histotypes, including typical carcinoid (TC), atypical (AC), large cell carcinoma (LCNEC), and small lung (SCLC). This classification was designed to be applied surgical specimens mostly anchored in morphological parameters, resulting considerable overlapping among PNENs, which may result important challenges for clinicians’ decisions the case of biopsies. Since PNENs originate from neuroectodermic cells,...
The common epidermal growth factor receptor (EGFR) mutations, such as the L858R point mutation in exon 21 and in-frame deletional 19, have been definitively associated with response to EGFR-tyrosine kinase inhibitors (EGFR-TKI). However, clinical outcome treatment for many other rarer mutations are still unclear. In this study, we report results of Brazilian patients stage IB-IIIA non-small cell lung cancer (NSCLC) following complete resection minimal residual disease EGFR treated adjuvant...