A5014532779- Telomeres, Telomerase, and Senescence
- Vitamin D Research Studies
- Pancreatic and Hepatic Oncology Research
- Cancer Risks and Factors
- Bone health and osteoporosis research
- Healthcare Policy and Management
- Emergency and Acute Care Studies
- Ovarian cancer diagnosis and treatment
- BRCA gene mutations in cancer
- Primary Care and Health Outcomes
- Health, Environment, Cognitive Aging
- Folate and B Vitamins Research
- Pancreatitis Pathology and Treatment
- Estrogen and related hormone effects
- Health Systems, Economic Evaluations, Quality of Life
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- Advances in Oncology and Radiotherapy
- Head and Neck Cancer Studies
- Epigenetics and DNA Methylation
- Retinoids in leukemia and cellular processes
- Intergenerational Family Dynamics and Caregiving
- Heart Failure Treatment and Management
Enzo Life Sciences (United States)
2024
Truven Health Analytics (United States)
2014-2021
Lehigh University
2020-2021
The University of Texas MD Anderson Cancer Center
2013-2015
University of Wisconsin–Madison
2007-2014
Mayo Clinic
2012-2014
National Cancer Institute
2014
University of Wisconsin Carbone Cancer Center
2007-2013
Mayo Clinic in Florida
2013
University of Michigan
2013
Abstract Vitamin D and its analogues exhibit potent antitumor effects in many tissues, including the pancreas. Normal malignant pancreatic tissues were recently shown to express high levels of vitamin 1-α-hydroxylase, which converts circulating 25-hydroxyvitamin active 1,25-dihydroxyvitamin D. We examined associations between dietary intake D, calcium, retinol subsequent risk for cancer. conducted prospective studies cohorts 46,771 men ages 40 75 years as 1986 (the Health Professionals...
The presence of multiple chronic conditions (MCCs) complicates inpatient hospital care, leading to higher costs and utilization. Multimorbidity also primary increasing the likelihood hospitalization for ambulatory care sensitive conditions. purpose this study was evaluate how MCCs relate utilization 2012 Agency Healthcare Research Quality (AHRQ) Cost Utilization Project (HCUP) State Inpatient Databases (SID) provided data carry out a cross-sectional analysis 1.43 million claims related...
Abstract Treatment of head and neck squamous cell carcinoma, HNSCC, often requires multimodal therapy, including radiation therapy. The efficacy radiotherapy in controlling locoregional recurrence, the most frequent cause death from is critically important for patient survival. One potential biomarker to determine radioresistance TP53 whose alterations are predictive poor response. DNA-damaging reactive oxygen species (ROS) a by-product ionizing that lead activation p53, transcription p21...
Background: Diabetes appears to be associated with the development of pancreatic cancer. Three large prospective cohort studies observed a statistically significant relationbetween obesity and cancer risk. Dietary patterns have been fasting insulin levels risk diabetes. To determine whether dietary are risk, we analyzed data from two studies. Methods: We combined for men women obtain total 366 cases incident 124 672 eligible participants. were obtained food frequency questionnaires in 1986...
Abstract We examined the association between serum calcium levels and risk for prostate cancer using a prospective cohort, National Health Nutrition Examination Survey (NHANES) NHANES Epidemiologic Follow-up Study. Eighty-five incident cases of 25 deaths occurred over 46,188 person-years follow-up. Serum was determined an average 9.9 years before diagnosis cancer. Comparing men in top with bottom tertile calcium, multivariable-adjusted relative hazard fatal 2.68 (95% confidence interval,...
Abstract We recently reported a significant positive association in the National Health and Nutrition Examination Survey between high levels of total calcium serum, measured prospectively, risk fatal prostate cancer. To confirm this, we examined associations ionized serum cancer mortality an independent cohort, Third Survey. Twenty-five deaths occurred over 56,625 person-years follow-up. Compared with men lowest tertile calcium, multivariate-adjusted relative for death from highest was 2.07...
Telomeres, the ends of chromosomes, are critical for maintaining genomic stability and grow shorter with age. Shortened telomeres in pancreatic tissue play a key role pathogenesis cancer, peripheral blood leukocytes (PBL) have been associated increased risk several cancer types. We hypothesized that higher cancer.Telomere length was measured PBLs using quantitative real-time PCR 499 cases 963 cancer-free controls from Mayo Clinic. ORs confidence intervals (CI) were computed logistic...
Abstract Accidental spillage of 37,9001 100% phenol (carbolic add) in July 1974 caused chemical contamination wells a rural area southern Wisconsin. Human illness characterized by diarrhea, mouth sores, dark urine, and burning the was subsequently reported seventeen individuals who consumed contaminated water; their estimated intake 10 to 240 mg/person/day. Clustering illnesses time place, as well similarity these cases previously documented poisoning, suggest that water illness. Physical...
BackgroundSeveral observational studies have recently suggested an inverse association of circulating levels vitamin D with blood pressure. These findings been based mainly on Caucasian populations; whether this also exists among Hispanic and African Americans has yet to be definitively determined. This study investigates the 25-hydroxyvitamin (25[OH]D) pressure in Americans.
The pathophysiological consequences of caregiving have not been fully elucidated. We evaluated how caregiving, stress, and caregiver strain were associated with shorter relative telomere length (RTL), a marker cellular aging. Caregivers (n = 240) some noncaregivers 98) in the 2008–2010 Survey Health Wisconsin, comprising representative sample Wisconsin adults aged 21–74 years, reported their sociodemographic, health, psychological characteristics. RTL was assayed from blood or saliva...
Laboratory and human studies suggest that folate intake may influence the risk of some cancers. However, prospective information about relation between exocrine pancreatic cancer is limited. The authors examined dietary to in two large US cohorts. Folate was assessed by food frequency questionnaire 1984 women 1986 men. Multivariate relative risks were adjusted for age, energy intake, cigarette smoking, body mass index, diabetes, height. During 14 years' follow-up each cohort, 326 incident...
IntroductionColorectal cancer (CRC) tumor DNA is characterized by chromosomal damage termed instability (CIN) and excessively shortened telomeres. Up to 80% of CRC microsatellite stable (MSS) historically considered be chromosomally unstable (CIN+). However, phenotyping depicts some MSS with little or no genetic changes, thus being (CIN-). CIN- tumors have not been assessed for telomere attrition. Experimental DesignMSS rectal cancers from patients ≤50 years old Stage II (B2 higher) III...
OBJECTIVES: Telomeres are nucleoprotein structures that cap the end of chromosomes and shorten with sequential cell divisions in normal aging. Short telomeres also implicated incidence many cancers, but evidence is not conclusive for colorectal cancer (CRC). Therefore, aim this study was to assess association CRC telomere length. METHODS: In case–control study, we measured relative length from peripheral blood leukocytes (PBLs) DNA quantitative PCR 598 patients 2,212 healthy controls....
Higher levels of total and ionized serum calcium have been shown to predict fatal prostate cancer in prospective studies. Because the follow-up time these studies was relatively short, associations could reflect effect clinically significant but occult tumors on levels. If this were true, mortality rates among men with higher should be during early period decline thereafter.We tested hypothesis by estimating relative risk death from National Health Nutrition Examination Survey III for...